{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T23:36:37Z","timestamp":1724888197845},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:p>PTH metabolism is complex and the circulating forms include the intact 1-84 molecule as well as several carboxyl-terminal fragments. The first generation of PTH assays included several types of competitive assays, with specificities that spanned carboxyl, mid-region and amino-terminal portions of the molecule. The limitations of these assays and the methodological evolution led to the description of 2nd generation non-competitive immunometric assays for PTH in the late 80's, based on the recognition of the PTH molecule by two different antibodies, one directed against de amino-terminal and other against the carboxyl-terminal segments. The observation that in some circumstances \"long\" carboxyl-terminal segments were also measured by 2nd generation assays led to the development of 3rd generation assays based on amino-terminal specific antibodies that are specific for the first amino acids, measuring only the molecular forms that activate PTH1R. The practical and cost-benefit advantages of these assays are still debatable. The recent observation that carboxyl-terminal fragments of PTH have biological activity via a distinct receptor than PTH1R, points to the future need of more than one assay in order to evaluate parathyroid hormone function.<\/jats:p>","DOI":"10.1590\/s0004-27302006000400007","type":"journal-article","created":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T17:30:21Z","timestamp":1165944621000},"page":"621-627","source":"Crossref","is-referenced-by-count":6,"title":["Evolution of PTH assays"],"prefix":"10.1590","volume":"50","author":[{"given":"Jos\u00e9 Gilberto H.","family":"Vieira","sequence":"first","affiliation":[{"name":"Laboratorio Fleury; UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilda","family":"Kunii","sequence":"additional","affiliation":[{"name":"UNIFESP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f4nia","family":"Nishida","sequence":"additional","affiliation":[{"name":"Laboratorio 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