{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:13:11Z","timestamp":1787983991093,"version":"build-2784847793"},"reference-count":48,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>O hirsutismo \u00e9 um dos sinais das s\u00edndromes hiperandrog\u00eanicas. Uma abordagem pr\u00e1tica consiste em dividir as s\u00edndromes hiperandrog\u00eanicas em virilizantes e n\u00e3o virilizantes, de acordo com a presen\u00e7a ou aus\u00eancia de sinais de viriliza\u00e7\u00e3o. Um caso de uma paciente com hirsutismo e com uma concentra\u00e7\u00e3o basal e ap\u00f3s est\u00edmulo com ACTH(1-24) elevada de 17-OHP \u00e9 discutido. A aus\u00eancia de sinais de viriliza\u00e7\u00e3o e a hist\u00f3ria cl\u00ednica tornavam pouco prov\u00e1veis etiologias como neoplasias virilizantes e a hipertecose de ov\u00e1rio. Dentre as causas das s\u00edndromes n\u00e3o virilizantes, a presen\u00e7a de dist\u00farbio menstrual e hiperandrogenemia descartou o hirsutismo idiop\u00e1tico. De acordo com o Consenso de Rotterdam, considerou-se o diagn\u00f3stico de s\u00edndrome dos ov\u00e1rios polic\u00edsticos, procedendo-se \u00e0 exclus\u00e3o da forma n\u00e3o cl\u00e1ssica da hiperplasia adrenal cong\u00eanita por defici\u00eancia da 21-hidroxilase. A concentra\u00e7\u00e3o de 17-OHP ap\u00f3s est\u00edmulo foi de 14 ng\/dL, sendo que, na depend\u00eancia do limite de corte considerado, seria compat\u00edvel com esta doen\u00e7a. Embora a regi\u00e3o promotora do gene n\u00e3o tenha sido estudada, do ponto de vistas pr\u00e1tico pode-se considerar que este diagn\u00f3stico tenha sido exclu\u00eddo, uma vez que muta\u00e7\u00f5es nessa regi\u00e3o s\u00e3o raras.<\/jats:p>","DOI":"10.1590\/s0004-27302006000600019","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T11:49:50Z","timestamp":1169034590000},"page":"1108-1116","source":"Crossref","is-referenced-by-count":2,"title":["Hirsutismo: diagn\u00f3stico diferencial"],"prefix":"10.1590","volume":"50","author":[{"given":"Jos\u00e9 Antonio M.","family":"Marcondes","sequence":"first","affiliation":[{"name":"HCFMUSP"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1210\/jcem-21-11-1440","article-title":"Clinical assessment of body hair growth in women","volume":"21","author":"Ferriman D","year":"1961","journal-title":"J Clin 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