{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T15:24:16Z","timestamp":1649172256874},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Mulher de 63 anos procurou endocrinologista para seguimento de osteoporose. Densitometria \u00f3ssea revelava T L1-L4= -3,5 DP [Densidade mineral \u00f3ssea (DMO): 0,766 g\/cm\u00b2] e Tcolo f\u00eamur= -2,4 DP (DMO: 0,716 g\/cm\u00b2). Em uso de c\u00e1lcio e vitamina D h\u00e1 2 anos. Hipotireoidismo h\u00e1 5 anos em uso de levotiroxina. Introduzido alendronato 70 mg\/semana com ganho significativo de massa \u00f3ssea no primeiro ano (6,1%, igualmente em coluna e colo de f\u00eamur). Ap\u00f3s 5 anos de seguimento, paciente passou a apresentar emagrecimento, anemia e piora dos n\u00edveis densitom\u00e9tricos (perda de 12,6% em coluna lombar e 20,9% em colo de f\u00eamur). Anamnese revelou quadro de diarr\u00e9ia intermitente h\u00e1 2 anos, levando \u00e0 suspeita de doen\u00e7a cel\u00edaca. Pesquisa de anticorpos anti-gliadina e anti-endom\u00edsio resultou positiva: 25,3 U\/mL (&lt; 20) e 1\/5 U\/mL (VR: negativo), respectivamente. Bioqu\u00edmica \u00f3ssea mostrava c\u00e1lcio e f\u00f3sforo normais, paratorm\u00f4nio aumentado: 283 pg\/mL (10-65) e marcadores de reabsor\u00e7\u00e3o \u00f3ssea aumentados, sugerindo hiperparatireoidismo secund\u00e1rio \u00e0 s\u00edndrome mal-absortiva. Ap\u00f3s 1 ano de dieta isenta de gl\u00faten, houve melhora dos sintomas mal-absortivos e importante aumento de DMO (47,3% em coluna lombar e 31,6% em colo de f\u00eamur), refor\u00e7ando o diagn\u00f3stico de doen\u00e7a cel\u00edaca como fator agravante de osteoporose nesta paciente.<\/jats:p>","DOI":"10.1590\/s0004-27302006000600022","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T11:49:50Z","timestamp":1169034590000},"page":"1127-1132","source":"Crossref","is-referenced-by-count":2,"title":["Relato de caso: doen\u00e7a cel\u00edaca rec\u00e9m-diagnosticada como fator agravante de osteoporose em mulher idosa"],"prefix":"10.1590","volume":"50","author":[{"given":"Camila C.","family":"Pereira","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique S.","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o 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