{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T20:12:29Z","timestamp":1773519149972,"version":"3.50.1"},"reference-count":56,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Diversas altera\u00e7\u00f5es end\u00f3crinas s\u00e3o descritas na obesidade. O eixo corticotr\u00f3fico encontra-se hiper-responsivo, com maior depura\u00e7\u00e3o dos horm\u00f4nios e n\u00edvel de cortisol normal. A caracteriza\u00e7\u00e3o do pseudo-Cushing \u00e9 importante. A leptina parece ser um horm\u00f4nio permissivo para o desencadeamento da puberdade. Em adultos, as gonadotrofinas s\u00e3o normais, hiperandrogenismo e hiperestrogenismo s\u00e3o encontrados. Nas mulheres, a resist\u00eancia insul\u00ednica \u00e9 central no desenvolvimento da s\u00edndrome dos ov\u00e1rios polic\u00edsticos (SOP), associada a hiperandrogenemia ovariana. Nos obesos, GH geralmente \u00e9 baixo e IGF1 normal. A fun\u00e7\u00e3o tireoidiana \u00e9 habitualmente normal nos obesos.<\/jats:p>","DOI":"10.1590\/s0004-27302007000100007","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T13:34:19Z","timestamp":1176298459000},"page":"34-41","source":"Crossref","is-referenced-by-count":11,"title":["Eixos hormonais na obesidade: causa ou efeito?"],"prefix":"10.1590","volume":"51","author":[{"given":"Roberta A.","family":"Lordelo","sequence":"first","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio C.","family":"Mancini","sequence":"additional","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00edntia","family":"Cercato","sequence":"additional","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Halpern","sequence":"additional","affiliation":[{"name":"USP"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"6","key":"ref1","first-page":"1853","article-title":"Stress-related cortisol secretion in men: relationship with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities","volume":"83","author":"Rosmond R","year":"1998","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"ref2","first-page":"341","article-title":"The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution","volume":"77","author":"Pasquali R","year":"1993","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1210\/jcem-71-5-1215","article-title":"Steroid hormone receptors in human adipose tissues","volume":"71","author":"Rebuffe-Scrive M","year":"1990","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1210\/endo-127-4-1689","article-title":"Glucocorticoid receptor messenger ribonucleic acid in different regions of human adipose tissue","volume":"127","author":"Bronnegard M","year":"1990","journal-title":"Endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0013-7227","issn-type":"print"},{"issue":"9","key":"ref5","first-page":"501","article-title":"Effect of fat distribution on the pharmacokinetics of cortisol in obesity","volume":"36","author":"Lottenberg SA","year":"1998","journal-title":"Int J Clin Pharmacol Ther","ISSN":"https:\/\/id.crossref.org\/issn\/0946-1965","issn-type":"print"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1530\/acta.0.0810321","article-title":"Free cortisol in obesity: effect of fasting","volume":"81","author":"Tales A","year":"1976","journal-title":"Acta Endocrinologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-5598","issn-type":"print"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2165\/00024677-200201020-00002","article-title":"Classic and recent etiologies of Cushing syndrome: diagnosis and therapy","volume":"1","author":"Beauregard C","year":"2002","journal-title":"Treat Endocrinol"},{"key":"ref8","first-page":"S198","article-title":"Urinary free cortisol levels in obese patients","volume":"26","author":"Arguello AMC","year":"2002","journal-title":"Int J Obes Relat Metab Disord","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1210\/jcem-29-9-1191","article-title":"The diagnosis of hypercortisolism: Biochemical criteria differentiating patients form lean and obese normal subjects and from females on oral contraceptives","volume":"29","author":"Streeten DHP","year":"1969","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/0026-0495(80)90043-8","article-title":"Cortisol production in obesity","volume":"29","author":"Strain GW","year":"1980","journal-title":"Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1055\/s-2005-861374","article-title":"Obesity and cortisol status","volume":"37","author":"Salehi M","year":"2005","journal-title":"Horm Metabol Res"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1677\/joe.0.1670533","article-title":"Mechanisms of dysregulation of 11 beta-hydroxysteroid dehydrogenase type 1 in obese Zucker rats","volume":"167","author":"Livingstone DE","year":"2000","journal-title":"J Endocrinol","ISSN":"https:\/\/id.crossref.org\/issn\/0022-0795","issn-type":"print"},{"issue":"5549","key":"ref13","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1126\/science.1066285","article-title":"A transgenic model of visceral obesity and the metabolic syndrome","volume":"294","author":"Masuzaki H","year":"2001","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1210\/jcem.86.3.7453","article-title":"Tissue-specific dysregulation of cortisol metabolism in human obesity","volume":"86","author":"Rask E","year":"2001","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/oby.2004.3","article-title":"Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss","volume":"12","author":"Engeli S","year":"2004","journal-title":"Obes Res","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7323","issn-type":"print"},{"key":"ref16","series-title":"Adipose Tissue and Reproduction","first-page":"1","volume-title":"Body fat, menarche, fitness and fertility","author":"Frish RE","year":"1990"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0396-318","article-title":"Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin","volume":"12","author":"Chehab FF","year":"1996","journal-title":"Nat Genet","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1095\/biolreprod60.2.205","article-title":"Physiological perspectives on leptin as a regulator of reproduction: role in timing puberty","volume":"60","author":"Foster DL","year":"1999","journal-title":"Biol Reprod","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3363","issn-type":"print"},{"issue":"S3","key":"ref19","first-page":"55","article-title":"A role for leptin in sexual maturation and puberty?","volume":"51","author":"Kiess W","year":"1999","journal-title":"Horm Res","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0163","issn-type":"print"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/S0889-8529(05)70100-6","article-title":"Role of leptin during childhood growth and development","volume":"28","author":"Roemmich JN","year":"1999","journal-title":"Endocrinol Metab Clin North Am","ISSN":"https:\/\/id.crossref.org\/issn\/0889-8529","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1210\/jcem-45-6-1211","article-title":"Low serum testosterone and sex hormone binding globulin in massively obese men","volume":"45","author":"Glass AR","year":"1977","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2265.1981.tb00644.x","article-title":"The effect of weight loss on steroid secretion and binding in massively obese women","volume":"14","author":"Kopelman PG","year":"1981","journal-title":"Clin Endocrinol"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/sj.ijo.0801406","article-title":"Decreased androgen levels in massively obese men may be associated with impaired function of the gonadostat","volume":"24","author":"Lima N","year":"2000","journal-title":"Int J Obes Relat Metab Disord","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0039-128X(00)00223-3","article-title":"Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens","volume":"66","author":"Malacara JM","year":"2001","journal-title":"Steroids","ISSN":"https:\/\/id.crossref.org\/issn\/0039-128X","issn-type":"print"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0950-351X(05)80286-1","article-title":"Hormones and obesity","volume":"8","author":"Kopelman PG","year":"1994","journal-title":"Bailli\u00e8re's Clin Endocrinol Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1210\/jcem-57-2-304","article-title":"Relationship of androgenic activity to body fat topography, fat cell morphology and metabolic aberrations in premenopausal women","volume":"57","author":"Evans DJ","year":"1983","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"4","key":"ref27","first-page":"997","article-title":"Pathogenesis of decreased androgen levels in obese men","volume":"79","author":"Giagulli VA","year":"1994","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2265.1980.tb02721.x","article-title":"Abnormal sex steroid secretion and binding in massively obese women","volume":"12","author":"Kopelman PG","year":"1980","journal-title":"Clin Endocrinol"},{"key":"ref29","first-page":"624","article-title":"Changes in circulating steroids with aging in post-menopausal women","volume":"57","author":"Meldrum DR","year":"1981","journal-title":"Obstet Gynecol","ISSN":"https:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"19","year":"2004","journal-title":"Hum Reprod","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"6","key":"ref31","first-page":"774","article-title":"Insulin resistance and the Polycystic Ovary Syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif A","year":"1997","journal-title":"Endocr Rev","ISSN":"https:\/\/id.crossref.org\/issn\/0163-769X","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic Ovary Syndrome","volume":"352","author":"Ehrmann DA","year":"2005","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/humrep\/16.7.1340","article-title":"Leptin concentrations in hirsute women with polycystic ovary syndrome or idiopathic hirsutism: influence on LH and relationship with hormonal, metabolic, and anthropometric measurements","volume":"16","author":"Spritzer PM","year":"2001","journal-title":"Hum Rep"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.fertnstert.2004.02.104","article-title":"A randomized, 48 week, placebo-controlled trial of intensive lifestyle modification and\/or metformin therapy in overweight women with polycystic ovary syndrome: a pilot study","volume":"82","author":"Hoeger KM","year":"2004","journal-title":"Fertil Steril","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1056\/NEJM199806253382603","article-title":"Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome","volume":"338","author":"Nestler JE","year":"1998","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0029-7844(97)00296-2","article-title":"Menstrual ciclicity after metformin therapy in polycystic ovary syndrome","volume":"90","author":"Velazquez EM","year":"1997","journal-title":"Obstet Gynecol","ISSN":"https:\/\/id.crossref.org\/issn\/0029-7844","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0026-0495(67)90076-5","article-title":"Effect of arginine on serum levels of insulin and growth hormone in obese subjects","volume":"16","author":"Copinschi G","year":"1967","journal-title":"Metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1210\/jcem-31-5-546","article-title":"Pituitary response to insulin-induced hypoglycemia in obese subjects before and after fasting","volume":"31","author":"Bell JP","year":"1970","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref39","first-page":"819","article-title":"Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: evidence for a marked somatotroph secretory capability in obesity","volume":"96","author":"Cordido F","year":"1993","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"S100","DOI":"10.1038\/sj.ijo.0801290","article-title":"Regulation of somatotroph cell function by the adipose tissue","volume":"24","author":"Dieguez C","year":"2000","journal-title":"Int J Obes","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1210\/jcem-63-2-481","article-title":"Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone and glucagon concentrations","volume":"63","author":"Golay A","year":"1986","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1530\/eje.0.1440251","article-title":"Effects of short-term administration of low-dose rhGH on IGF-1 levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH","volume":"144","author":"Maccario M","year":"2001","journal-title":"Eur J Endocrinol","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/oby.2006.51","article-title":"Effect of gastric bypass on spontaneus growth hormone and ghrelin release profiles","volume":"14","author":"Mancini MC","year":"2006","journal-title":"Obes Res","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7323","issn-type":"print"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0025-7125(16)30696-4","article-title":"Endocrine aspects of obesity","volume":"73","author":"Glass AR","year":"1989","journal-title":"Med Clin North Am","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7125","issn-type":"print"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1210\/jc.2001-011441","article-title":"Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome","volume":"87","author":"Gianotti L","year":"2002","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/oby.2003.27","article-title":"Effects of growth hormone administration in human obesity","volume":"11","author":"Shadid S","year":"2003","journal-title":"Obes Res","ISSN":"https:\/\/id.crossref.org\/issn\/1071-7323","issn-type":"print"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1590\/S0004-27302006000100010","article-title":"Efeito do horm\u00f4nio do crescimento sobre par\u00e2metros antropom\u00e9tricos e metab\u00f3licos na obesidade andr\u00f3ide","volume":"50","author":"Halpern A","year":"2006","journal-title":"Arq Bras Endocrinol Metab"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0140-6736(80)90715-1","article-title":"Treatment of obesity with triodothyronine and a very-low calorie liquid formula diet","author":"Moore R","year":"1980","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(02)01420-6","article-title":"Thyroid hormones in the pathogenesis and treatment of obesity","volume":"440","author":"Marcin Krotkiewski","year":"1980","journal-title":"Eur J Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2999","issn-type":"print"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1055\/s-2007-979169","article-title":"Influence of zinc and selenium deficiency on parameters relating to thyroid hormone metabolism","volume":"28","author":"Kralik A","year":"1996","journal-title":"Horm Metab Res","ISSN":"https:\/\/id.crossref.org\/issn\/0018-5043","issn-type":"print"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/sj.ijo.0800493","article-title":"Small dose of triiodothyronine can change some risk factors associated with abdominal obesity","volume":"21","author":"Krotkiewski M","year":"1997","journal-title":"Int J Obes","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(02)01420-6","article-title":"Thyroid hormones in the pathogenesis and treatment of obesity","volume":"440","author":"Krotkiewski M","year":"2002","journal-title":"Eur J Pharmacol","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2999","issn-type":"print"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1381\/096089205774512537","article-title":"Prevalence of subclinical hypothyroidism in a morbidly obese population and improvement after weight loss induced by Roux-en-Y gastric bypass","volume":"15","author":"Moulin de Moraes CM","year":"2005","journal-title":"Obes Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0960-8923","issn-type":"print"},{"key":"ref54","first-page":"1118","article-title":"Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement","volume":"82","author":"Adsani H","year":"1997","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1210\/jcem.87.4.8378","article-title":"Lipoprotein profile in subclinical hypothyroidism: response to levothyroxine replacement, a randomized placebo-controlled study","volume":"87","author":"Caraccio N","year":"2002","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.ijo.0801516","article-title":"Fat balance and serum leptin concentration in normal, hypothyroid and hyperthyroid rats","volume":"25","author":"Iossa S","year":"2001","journal-title":"Int J Obes","ISSN":"https:\/\/id.crossref.org\/issn\/0307-0565","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v51n1\/03.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T07:30:06Z","timestamp":1556350206000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302007000100007&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0004-27302007000100007"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302007000100007","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}