{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:59:24Z","timestamp":1751471964626},"reference-count":48,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>A miocardiopatia diab\u00e9tica \u00e9 uma doen\u00e7a do m\u00fasculo card\u00edaco causada pelo diabetes mellitus e n\u00e3o relacionada \u00e0s patologias vascular e valvular ou \u00e0 hipertens\u00e3o arterial sist\u00eamica. Observa\u00e7\u00f5es experimentais e cl\u00ednicas t\u00eam demonstrado hipertrofia, necrose, apoptose e aumento do tecido intersticial mioc\u00e1rdico. Acredita-se que a miocardiopatia diab\u00e9tica seja decorrente de anormalidades metab\u00f3licas como hiperlipidemia, hiperinsulinemia e hiperglicemia, e de altera\u00e7\u00f5es do metabolismo card\u00edaco. Tais altera\u00e7\u00f5es podem causar aumento do estresse oxidativo, fibrose intersticial, perda celular e comprometimento do tr\u00e2nsito intracelular de \u00edons e da homeostase do c\u00e1lcio. Clinicamente, \u00e9 poss\u00edvel a detec\u00e7\u00e3o de disfun\u00e7\u00e3o diast\u00f3lica assintom\u00e1tica na fase inicial. No momento em que surgem os sinais e sintomas de insufici\u00eancia card\u00edaca, observamos disfun\u00e7\u00e3o diast\u00f3lica isolada, sendo que o comprometimento da fun\u00e7\u00e3o sist\u00f3lica, habitualmente, \u00e9 tardio. O tratamento da miocardiopatia diab\u00e9tica com insufici\u00eancia card\u00edaca n\u00e3o difere das miocardiopatias de outras etiologias e deve seguir as diretrizes de acordo com o comprometimento da fun\u00e7\u00e3o ventricular, se diast\u00f3lica isolada ou diast\u00f3lica e sist\u00f3lica.<\/jats:p>","DOI":"10.1590\/s0004-27302007000200004","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T03:14:16Z","timestamp":1195182856000},"page":"160-167","source":"Crossref","is-referenced-by-count":16,"title":["Miocardiopatia diab\u00e9tica"],"prefix":"10.1590","volume":"51","author":[{"given":"Katashi","family":"Okoshi","sequence":"first","affiliation":[{"name":"UNESP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julliano F. 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