{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T16:41:37Z","timestamp":1780764097832,"version":"3.54.1"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Telarca precoce, desenvolvimento mam\u00e1rio antes dos 8 anos de idade, apresenta dois picos de incid\u00eancia, nos dois primeiros anos de vida e ap\u00f3s os 6 anos de idade. Uma menina de 4,75 anos apresentou-se com telarca associada \u00e0 ingest\u00e3o excessiva de fitoestr\u00f3genos. O desenvolvimento puberal M2P1-2, os n\u00edveis hormonais e o US p\u00e9lvico eram compat\u00edveis com puberdade precoce perif\u00e9rica. Durante o seguimento, observou-se ingest\u00e3o di\u00e1ria de alimentos baseados em soja (&gt; 40 mg fitoestr\u00f3genos\/dia). Soja cont\u00e9m fitoestr\u00f3genos, principalmente geniste\u00edna e daidze\u00edna. Embora menos potentes do que o estradiol, sua concentra\u00e7\u00e3o pode ser 13.000 a 22.000 vezes maior em crian\u00e7as alimentadas somente com f\u00f3rmulas baseadas em soja. Os pais foram aconselhados a reduzir para uma vez na semana o seu fornecimento na dieta. O desenvolvimento puberal cessou em M2-3P1 e a paciente, com 8,66 anos, continua a desenvolver-se com idades \u00f3ssea e cronol\u00f3gica equivalentes. Quest\u00f5es relacionadas \u00e0 seguran\u00e7a alimentar, principalmente de alimentos baseados em soja, permanecem sem respostas precisas. Embora sejam conhecidas as etiologias da puberdade precoce n\u00e3o progressiva e da telarca prematura, neste caso esteve fortemente relacionada \u00e0 ingest\u00e3o excessiva de soja e de outros alimentos ricos em fitoestr\u00f3genos que poderiam ter desencadeado a telarca atuando como desreguladores end\u00f3crinos.<\/jats:p>","DOI":"10.1590\/s0004-27302007000300021","type":"journal-article","created":{"date-parts":[[2007,11,16]],"date-time":"2007-11-16T03:16:06Z","timestamp":1195182966000},"page":"500-503","source":"Crossref","is-referenced-by-count":8,"title":["Ingest\u00e3o excessiva de fitoestr\u00f3genos e telarca precoce: relato de caso com poss\u00edvel correla\u00e7\u00e3o"],"prefix":"10.1590","volume":"51","author":[{"given":"\u00c9rika M.","family":"Fortes","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta 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