{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:30:22Z","timestamp":1791405022923,"version":"4.3.3"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>The RET\/PTC oncogene has been isolated almost twenty years ago. During these years, the research has given a final answer to several questions. In fact, it has been demonstrated that: a) RET\/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET\/PTC activation is essentially restricted to the papillary histotype and to the H\u00fcrthle thyroid tumors; c) its incidence increases after exposure to radiations. However, some questions have not found a final answer yet: a) which is the real frequency of RET\/PTC activation? Likely it is around 20%, but this point is still questionable; b) which other gene modifications are required to lead a thyroid cell carrying a RET\/PTC oncogene to the malignant phenotype?, and c) is there any correlation between RET\/PTC activation and clinical parameters? We hope that these questions will have a clear answer in the near future.<\/jats:p>","DOI":"10.1590\/s0004-27302007000500010","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T22:17:28Z","timestamp":1195165048000},"page":"731-735","source":"Crossref","is-referenced-by-count":22,"title":["20 years of RET\/PTC in thyroid cancer: clinico-pathological correlations"],"prefix":"10.1590","volume":"51","author":[{"given":"Alfredo","family":"Fusco","sequence":"first","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli; European School of Molecular Medicine,  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Santoro","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Napoli; European School of Molecular Medicine,  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/328170a0","article-title":"A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases","volume":"328","author":"Fusco A","year":"1987","journal-title":"Nature","ISSN":"https:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/0092-8674(90)90659-3","article-title":"PTC is a novel rearranged form of the RET proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas","volume":"60","author":"Grieco M","year":"1990","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/eje.1.02289","article-title":"RET\/PTC activation in papillary thyroid carcinoma","volume":"155","author":"Santoro M","year":"2006","journal-title":"Eur J Endocrinol","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"ref4","first-page":"509","article-title":"Molecular characterization of RET\/PTC 3: a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma","volume":"9","author":"Santoro M","year":"1994","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1073\/pnas.89.5.1616","article-title":"Characterization of a chromosome 10q inversion juxtaposing RET and H4 genes and creating the oncogenic sequence PTC","volume":"89","author":"Pierotti MA","year":"1991","journal-title":"Proc Natl Acad Sci USA","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"ref6","first-page":"1821","article-title":"Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET\/PTC1 oncogene in transgenic mice","volume":"12","author":"Santoro M","year":"1996","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"ref7","first-page":"1207","article-title":"RET\/PTC oncogene activation is an early event in thyroid carcinogenesis","volume":"11","author":"Viglietto G","year":"1995","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/S0002-9440(10)61164-9","article-title":"Assessment of RET\/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer","volume":"60","author":"Fusco A","year":"2002","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/00000478-200012000-00004","article-title":"RET\/PTC activation in hyalinizing trabecular tumors of the thyroid","volume":"24","author":"Papotti M","year":"2000","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"key":"ref10","first-page":"287","article-title":"RET\/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes","volume":"4","author":"Tallini G","year":"1998","journal-title":"Clin Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1210\/jcem.87.1.8180","article-title":"The RET\/PTC oncogene is frequently activated in oncocytic thyroid tumors (H\u00fcrthle cell adenomas and carcinomas), but not in oncocytic hyperplastic lesions","volume":"87","author":"Chiappetta G","year":"2002","journal-title":"J Clin Endocrinol and Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1210\/jc.2006-1006","article-title":"Prevalence of RET\/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity","volume":"91","author":"Zhu Z","year":"2006","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1172\/JCI115743","article-title":"RET oncogene activation in human thyroid neoplasms is restricted to the papillary carcinoma subtype","volume":"89","author":"Santoro M","year":"1992","journal-title":"J Clin Invest","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1126\/science.290.5489.138","article-title":"Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells","volume":"290","author":"Nikiforova MN","year":"2000","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref15","first-page":"2459","article-title":"High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident","volume":"11","author":"Klugbauer S","year":"1995","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"key":"ref16","first-page":"1690","article-title":"Distinct patterns of ret rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children","volume":"57","author":"Nikiforov Y","year":"1997","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/(SICI)1097-0215(19990105)80:1<32::AID-IJC7>3.0.CO;2-L","article-title":"Distinct frequency of ret rearrangements in papillary thyroid carcinomas of children and adults from Belarus","volume":"80","author":"Smida J","year":"1999","journal-title":"Int J Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/106689690201000104","article-title":"Prevalence of RET\/PTC rearrangements in Hashimoto\u2019s thyroiditis and papillary thyroid carcinomas","volume":"10","author":"Nikiforova MN","year":"2002","journal-title":"Int J Surg Pathol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1210\/jc.2006-0240","article-title":"RET\/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto\u2019s thyroiditis share low-level recombination events with a subset of papillary carcinoma","volume":"91","author":"Rhoden KJ","year":"2006","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/eje.0.1480505","article-title":"Ret\/PTC activation does not influence clinical and pathological features of adult papillary thyroid carcinomas","volume":"148","author":"Puxeddu E","year":"2003","journal-title":"Eur J Endocrinol","ISSN":"https:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v51n5\/a10v51n5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T16:17:10Z","timestamp":1495729030000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302007000500010&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0004-27302007000500010"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302007000500010","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}