{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T18:15:41Z","timestamp":1649096141236},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>Embora a reposi\u00e7\u00e3o estrog\u00eanica esteja dispon\u00edvel h\u00e1 mais de 6 d\u00e9cadas, as mulheres e mesmo os profissionais da sa\u00fade est\u00e3o confusos pelas opini\u00f5es divergentes em rela\u00e7\u00e3o aos riscos e benef\u00edcios da terapia hormonal na menopausa (THM), estrog\u00eanica (TE) ou estro-progestag\u00eanica (TEP). A principal indica\u00e7\u00e3o para terap\u00eautica hormonal na menopausa \u00e9 o al\u00edvio dos sintomas menopausais, tais como sintomas vasomotores, altera\u00e7\u00f5es g\u00eanito-urin\u00e1rias e a preven\u00e7\u00e3o de osteoporose nas pacientes de risco. Em outras \u00e1reas de pesquisa, principalmente ao que se refere aos efeitos nos sistemas cardiovasculares e nervoso central, os resultados atuais na literatura s\u00e3o conflitivos. O tratamento por mais de 5 anos n\u00e3o adiciona risco significativo para c\u00e2ncer de mama, mas diminui significativamente o risco de fratura osteopor\u00f3tica. Algumas mulheres podem ser suscept\u00edveis a risco tromboemb\u00f3lico precoce, mas quando a TH for adequada ap\u00f3s avalia\u00e7\u00e3o individualizada, os benef\u00edcios superam os riscos e o tratamento deve ser recomendado. Estudos futuros s\u00e3o necess\u00e1rios para identificar novas indica\u00e7\u00f5es para TH e diminuir ou abolir seus riscos. A pesquisa cl\u00ednica continua na identifica\u00e7\u00e3o de fatores gen\u00e9ticos que possam influenciar a resposta individual \u00e0 TH, diferentes formula\u00e7\u00f5es estrog\u00eanicas, diferentes vias de administra\u00e7\u00e3o e libera\u00e7\u00e3o, al\u00e9m das op\u00e7\u00f5es de dose. Nas mulheres que apresentam os sintomas da s\u00edndrome climat\u00e9rica de forma severa durante a peri e p\u00f3s-menopausa j\u00e1 existem evid\u00eancias conclusivas oriundas de v\u00e1rios estudos randomizados controlados de que a TH \u00e9 a \u00fanica terapia com resultados satisfat\u00f3rios. Os m\u00e9dicos devem sempre fazer suas decis\u00f5es terap\u00eauticas com base nos riscos e benef\u00edcios individuais de cada paciente, tendo a responsabilidade e o dever de promover as condi\u00e7\u00f5es para a mulher atravessar a transi\u00e7\u00e3o menop\u00e1usica com qualidade de vida.<\/jats:p>","DOI":"10.1590\/s0004-27302007000600007","type":"journal-article","created":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T22:18:27Z","timestamp":1195165107000},"page":"938-942","source":"Crossref","is-referenced-by-count":6,"title":["Terapia hormonal da menopausa"],"prefix":"10.1590","volume":"51","author":[{"given":"Dolores","family":"Pardini","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women","volume":"280","author":"Hulley S","year":"1998","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy post-menopausal women: principal results from the Women\u2019s Health Initiative randomized controlled trial","volume":"288","author":"Rossouw JE","year":"2002","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1001\/jama.287.20.2668","article-title":"Effect of lower doses of conjugated equine estrogens with and without medroxyprogesterone acetate on bone in early postmenopausal women","volume":"287","author":"Lindsay R","year":"2002","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1001\/jama.290.13.1729","article-title":"Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women\u2019s Health Initiative Randomized Trial","volume":"290","author":"Cauley JA","year":"2003","journal-title":"JAMA","ISSN":"http:\/\/id.crossref.org\/issn\/0098-7484","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM199608153350701","article-title":"Postmenopausal estrogen and progestin use and the risk of cardiovascular disease","volume":"335","author":"Grodstein F","year":"1996","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"14","key":"ref6","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"; Women\u2019s Health Initiative Steering Committee: Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. 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