{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:20:46Z","timestamp":1794579646828,"version":"4.9.1"},"reference-count":47,"publisher":"FapUNIFESP (SciELO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>A utiliza\u00e7\u00e3o de ester\u00f3ides anabolizantes por indiv\u00edduos que desejam aumentar sua performance f\u00edsica, ou simplesmente para fins est\u00e9ticos, tem atingido \u00edndices alarmantes nas \u00faltimas tr\u00eas d\u00e9cadas. Al\u00e9m dos efeitos desejados, uma infinidade de efeitos colaterais j\u00e1 foi bem descrita na literatura, como v\u00e1rios tipos de c\u00e2ncer, ginecomastia, peliosis hepatis, insufici\u00eancia renal, viriliza\u00e7\u00e3o, dentre outros. Sobre a fun\u00e7\u00e3o tire\u00f3idea, o efeito mais pronunciado em seres humanos \u00e9 a diminui\u00e7\u00e3o da TBG, com conseq\u00fcente diminui\u00e7\u00e3o s\u00e9rica de T3 e T4 totais, dependendo, por\u00e9m, da susceptibilidade da mol\u00e9cula \u00e0 aromatiza\u00e7\u00e3o e conseq\u00fcente transforma\u00e7\u00e3o em estr\u00f3geno. Em ratos, o tratamento com ester\u00f3ides anabolizantes altera a metaboliza\u00e7\u00e3o perif\u00e9rica dos horm\u00f4nios tire\u00f3ideos e tamb\u00e9m parece causar importante efeito proliferativo sobre as c\u00e9lulas tire\u00f3ideas. Assim, o presente artigo visa rever os dados publicados acerca dos efeitos de doses suprafisiol\u00f3gicas de ester\u00f3ides anabolizantes sobre a fun\u00e7\u00e3o tire\u00f3idea, refor\u00e7ando o perigo que a utiliza\u00e7\u00e3o indiscriminada dessas drogas pode causar \u00e0 sa\u00fade.<\/jats:p>","DOI":"10.1590\/s0004-27302007000900003","type":"journal-article","created":{"date-parts":[[2008,1,18]],"date-time":"2008-01-18T08:17:24Z","timestamp":1200644244000},"page":"1417-1424","source":"Crossref","is-referenced-by-count":14,"title":["Abuso de ester\u00f3ides anabolizantes e seu impacto sobre a fun\u00e7\u00e3o tire\u00f3idea"],"prefix":"10.1590","volume":"51","author":[{"given":"Rodrigo S.","family":"Fortunato","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de 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