{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T08:42:21Z","timestamp":1648629741390},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>A principal complica\u00e7\u00e3o hiperglic\u00eamica no diabetes melito tipo 1 (DM1) \u00e9 a cetoacidose diab\u00e9tica (CAD). Embora varia\u00e7\u00f5es nos protocolos possam ocorrer, os princ\u00edpios b\u00e1sicos que norteiam o tratamento devem ser os mesmos. A recupera\u00e7\u00e3o inicial da capacidade circulat\u00f3ria, com a infus\u00e3o r\u00e1pida de solu\u00e7\u00e3o salina na dose de 20 mL\/kg, que pode ser repetida, \u00e9 o ponto de partida para o tratamento. A partir da\u00ed, a reposi\u00e7\u00e3o de volume \u00e9 relativamente lenta, e o objetivo principal \u00e9 corrigir gradualmente os dist\u00farbios metab\u00f3licos instalados, sem ocasionar varia\u00e7\u00f5es muito intensas e muito r\u00e1pidas na osmolalidade, fator de risco para complica\u00e7\u00f5es. Aten\u00e7\u00e3o ao desenvolvimento de edema cerebral que, uma vez suspeitado, deve ser imediatamente corrigido, sob pena de \u00f3bito ou seq\u00fcelas neurol\u00f3gicas. A administra\u00e7\u00e3o de insulina ultra-r\u00e1pida, por via subcut\u00e2nea, mostra-se eficaz e simplifica o atendimento do paciente. A CAD \u00e9 uma situa\u00e7\u00e3o grave, ainda com alta mortalidade, e seu tratamento deve ser dirigido aos pontos principais que levaram ao quadro cl\u00ednico, com corre\u00e7\u00f5es graduais, sob risco de se agravar o quadro.<\/jats:p>","DOI":"10.1590\/s0004-27302008000200025","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T04:19:27Z","timestamp":1209010767000},"page":"367-374","source":"Crossref","is-referenced-by-count":2,"title":["Complica\u00e7\u00f5es hiperglic\u00eamicas agudas no diabetes melito tipo 1 do jovem"],"prefix":"10.1590","volume":"52","author":[{"given":"Durval","family":"Damiani","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Damiani","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho,  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