{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T13:04:58Z","timestamp":1765112698632},"reference-count":49,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:p>O acometimento patol\u00f3gico do sistema nervoso no diabetes melito \u00e9 muito amplo e, freq\u00fcentemente, bastante grave. A preval\u00eancia de neuropatia diab\u00e9tica atinge n\u00edveis elevados com a evolu\u00e7\u00e3o temporal do diabetes, chegando, geralmente, a freq\u00fc\u00eancias acima de 50% de les\u00e3o neurol\u00f3gica em diferentes grupos de pacientes analisados em nosso meio e no exterior. A les\u00e3o neurol\u00f3gica nesta situa\u00e7\u00e3o patol\u00f3gica \u00e9 extensa no organismo humano diab\u00e9tico, envolvendo amplamente todo o sistema nervoso perif\u00e9rico nos seus componentes sensitivo-motor e auton\u00f4mico: com cl\u00ednica caracter\u00edstica e concordante com as hip\u00f3teses patog\u00eanicas de natureza metab\u00f3lica e\/ou microvascular. O sistema nervoso auton\u00f4mico \u00e9 o elemento fundamental na regula\u00e7\u00e3o da fun\u00e7\u00e3o da maior parte dos sistemas ou \u00f3rg\u00e3os no organismo, portanto, a sua les\u00e3o pode trazer importantes altera\u00e7\u00f5es para as fun\u00e7\u00f5es cardiovascular, respirat\u00f3ria, digestiva, urin\u00e1ria e genital, podendo influir na fun\u00e7\u00e3o vital de alguns desses \u00f3rg\u00e3os ou sistemas. Este artigo aborda as altera\u00e7\u00f5es decorrentes da les\u00e3o do sistema nervoso auton\u00f4mico, especialmente nos pacientes diab\u00e9ticos tipo 1, procurando dimensionar o risco de morbimortalidade.<\/jats:p>","DOI":"10.1590\/s0004-27302008000200028","type":"journal-article","created":{"date-parts":[[2008,4,24]],"date-time":"2008-04-24T04:19:31Z","timestamp":1209010771000},"page":"398-406","source":"Crossref","is-referenced-by-count":10,"title":["Neuropatia auton\u00f4mica: uma complica\u00e7\u00e3o de alto risco no diabetes melito tipo 1"],"prefix":"10.1590","volume":"52","author":[{"given":"Maria Cristina","family":"Foss-Freitas","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Marques Junior","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton Cesar","family":"Foss","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/mus.20785","article-title":"Diabetes mellitus and the peripheral nervous system: manifestations and mechanisms","volume":"36","author":"Zochodne DW","year":"2007","journal-title":"Muscle Nerve","ISSN":"http:\/\/id.crossref.org\/issn\/0148-639X","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ncpneuro0504","article-title":"Diabetic neuropathy: a review","volume":"3","author":"Said G","year":"2007","journal-title":"Nat Clin Pract Neurol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.106.634949","article-title":"Diabetic cardiovascular autonomic neuropathy","volume":"115","author":"Vnik Al","year":"2007","journal-title":"Circulation","ISSN":"http:\/\/id.crossref.org\/issn\/0009-7322","issn-type":"print"},{"key":"ref4","first-page":"198","article-title":"Neuropatia autonomica no paciente diab\u00e9tico","author":"Valensis P","year":"1997","journal-title":"Diab. 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