{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:36:23Z","timestamp":1773146183903,"version":"3.50.1"},"reference-count":57,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>A s\u00edndrome de Sheehan se caracteriza pelo hipopituitarismo p\u00f3s-parto secund\u00e1rio \u00e0 necrose hipofis\u00e1ria decorrente de hipotens\u00e3o ou choque em virtude de hemorragia maci\u00e7a durante ou logo ap\u00f3s o parto. Sua freq\u00fc\u00eancia vem caindo em todo o mundo, principalmente em pa\u00edses e regi\u00f5es mais desenvolvidas em raz\u00e3o da melhora nos cuidados obst\u00e9tricos, contudo, ainda \u00e9 freq\u00fcente em pa\u00edses em desenvolvimento onde os cuidados obst\u00e9tricos s\u00e3o mais prec\u00e1rios. A s\u00edndrome de Sheehan pode evoluir de maneira lenta com diagn\u00f3stico muitas vezes tardio e, ainda que alguns sinais de insufici\u00eancia hipofis\u00e1ria ocorram, logo ap\u00f3s o parto, s\u00e3o pouco valorizados. Seu diagn\u00f3stico precoce e o tratamento adequado s\u00e3o importantes para redu\u00e7\u00e3o da morbimortalidade das pacientes. Esta revis\u00e3o tem por objetivo descrever aspectos cl\u00ednicos, laboratoriais e terap\u00eauticos da s\u00edndrome de Sheehan, incluindo a nossa experi\u00eancia pessoal na reposi\u00e7\u00e3o com GH recombinante neste grupo de pacientes.<\/jats:p>","DOI":"10.1590\/s0004-27302008000500020","type":"journal-article","created":{"date-parts":[[2008,9,29]],"date-time":"2008-09-29T14:04:16Z","timestamp":1222697056000},"page":"872-878","source":"Crossref","is-referenced-by-count":13,"title":["Aspectos diagn\u00f3sticos e terap\u00eauticos da s\u00edndrome de Sheehan"],"prefix":"10.1590","volume":"52","author":[{"given":"D\u00e9bora Vieira","family":"Soares","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via L\u00facia","family":"Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, 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