{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:01:55Z","timestamp":1773320515721,"version":"3.50.1"},"reference-count":75,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:p>A hiper-homocisteinemia, quando considerada como fator causal de doen\u00e7as vasculares, tem suscitado muitas discuss\u00f5es. Estudos caso-controle, retrospectivos e prospectivos t\u00eam identificado rela\u00e7\u00e3o entre concentra\u00e7\u00f5es plasm\u00e1ticas elevadas de homociste\u00edna e doen\u00e7as vasculares. Na presente revis\u00e3o, objetivou-se compreender melhor a inter-rela\u00e7\u00e3o entre as concentra\u00e7\u00f5es plasm\u00e1ticas de homociste\u00edna e doen\u00e7as vasculares, al\u00e9m do envolvimento de fatores de risco cl\u00e1ssicos para a doen\u00e7a: os gen\u00e9ticos, como as muta\u00e7\u00f5es em genes que codificam as enzimas envolvidas no metabolismo da homociste\u00edna, e os nutricionais, como a defici\u00eancia de vitaminas do complexo B. Foram consultadas as publica\u00e7\u00f5es das principais bases de dados em sa\u00fade, no per\u00edodo de 1962 a 2009. O mecanismo pelo qual a hiper-homocisteinemia atua como fator de risco para doen\u00e7as vasculares ainda n\u00e3o est\u00e1 totalmente esclarecido; entretanto, sugere-se o envolvimento da disfun\u00e7\u00e3o endotelial e da peroxida\u00e7\u00e3o lip\u00eddica. O tratamento da hiper-homocisteinemia fundamenta-se na suplementa\u00e7\u00e3o alimentar e medicamentosa, com \u00e1cido f\u00f3lico e vitaminas B6 e B12.<\/jats:p>","DOI":"10.1590\/s0004-27302009000500007","type":"journal-article","created":{"date-parts":[[2010,1,7]],"date-time":"2010-01-07T14:38:31Z","timestamp":1262875111000},"page":"540-549","source":"Crossref","is-referenced-by-count":11,"title":["Hiper-homocisteinemia e risco cardiometab\u00f3lico"],"prefix":"10.1590","volume":"53","author":[{"given":"Helio","family":"Vannucchi","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Soares","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Taxa de mortalidade espec\u00edfica por doen\u00e7as do aparelho 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