{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:19:46Z","timestamp":1770887986430,"version":"3.50.1"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>OBJECTIVE: The aim of this study was to review the results of surgery for pediatric patients with Cushing's disease who were less than 18 years old and underwent transsphenoidal surgery in a specialized center during a 25-year period. SUBJECTS AND METHODS: Retrospective study, in which the medical records, histology and pituitary imaging of 15 consecutive pediatric patients with Cushing's disease (mean age: 13 years) were evaluated by the same team of endocrinologists and a neurosurgeon from 1982 to 2006. Patients were considered cured when there was clinical adrenal insufficiency and serum cortisol levels were below 1. 8 \u00b5g\/dL or 50 nmol\/L after one, two, three, or seven days following surgery; they therefore required cortisone replacement therapy. Follow-up was for a median time of 11.5 years (range: 2 to 25 years). RESULTS: Clinical and biochemical cure was achieved in 9\/15 patients (60%) exclusively after transsphenoidal surgery. Hypopituitarism was observed in four patients; growth hormone deficiency, in two; permanent diabetes insipidus, in one case. CONCLUSIONS: Cushing's disease is rare in children and adolescents. Transsphenoidal surgery is an effective and safe treatment in most of these patients. Plasma cortisol level &lt; 1. 8 \u00b5g\/dL following surgery is the treatment goal and is a good predictive factor for long-term cure of Cushing's disease.<\/jats:p>","DOI":"10.1590\/s0004-27302010000100004","type":"journal-article","created":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T12:15:10Z","timestamp":1271679310000},"page":"17-23","source":"Crossref","is-referenced-by-count":22,"title":["Surgical management of pediatric Cushing's disease: an analysis of 15 consecutive cases at a specialized neurosurgical center"],"prefix":"10.1590","volume":"54","author":[{"given":"Ricardo Santos de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret de","family":"Castro","sequence":"additional","affiliation":[{"name":"USP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonir Roberto Rauber","family":"Antonini","sequence":"additional","affiliation":[{"name":"USP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Eduardo","family":"Martinelli J\u00fanior","sequence":"additional","affiliation":[{"name":"USP, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrton Cust\u00f3dio","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio Rubens","family":"Machado","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11102-007-0056-4","article-title":"Diagnosis and treatment of pediatric Cushing's disease","volume":"10","author":"Savage 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