{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:56:25Z","timestamp":1778730985518,"version":"3.51.4"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>INTRODUCTION: Previous studies have suggested that Retinol Binding Protein 4 (RPB4), a protein produced by the adipose tissue, is associated with insulin resistance (IR). Congenital Generalized Lipodystrophy (CGL) is a rare disease characterized by IR and paucity of adipose tissue. Our objective was to determine RBP4 levels in patients with CGL. SUBJECTS AND METHODS: Six (6) patients with CGL and a healthy control group were selected to participate in the study. Anthropometric and biochemical variables were compared between groups. RESULTS: No difference was observed in RBP4 levels between the two groups (CGL 42.5 [12.5 - 127] vs. control 57.4 [15.9 - 165]; p = 0.78). On the other hand, leptin levels were significantly lower in CGL patients (CGL 0.65 [0.2 - 0.7] vs. control 10.9 [0.9 - 38.6]; p = 0.015). No correlation was found between RBP-4 and waist circunference (r = 0.18, p = 0.57), or BMI (r = 0.24, p = 0.45). CONCLUSION: RBP4 is not decreased in CGL. These results suggest that adipose tissue may not be the main source of RBP4.<\/jats:p>","DOI":"10.1590\/s0004-27302011000400007","type":"journal-article","created":{"date-parts":[[2011,7,14]],"date-time":"2011-07-14T15:48:58Z","timestamp":1310658538000},"page":"279-283","source":"Crossref","is-referenced-by-count":1,"title":["Serum retinol binding protein 4 is not decreased in congenital generalized lipodystrophy: a case series"],"prefix":"10.1590","volume":"55","author":[{"given":"Am\u00e9lio F.","family":"Godoy-Matos","sequence":"first","affiliation":[{"name":"Instituto Estadual de Diabetes e Endocrinologia do Rio de Janeiro (IEDE), Brazil; Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro (PUC-RJ), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo O.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Instituto Estadual de Diabetes e Endocrinologia do Rio de Janeiro (IEDE), Brazil; Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro (PUC-RJ), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"MacDowell","sequence":"additional","affiliation":[{"name":"Instituto Estadual de Diabetes e Endocrinologia do Rio de Janeiro (IEDE), Brazil; Pontif\u00edcia Universidade Cat\u00f3lica do Rio de Janeiro (PUC-RJ), Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izidro","family":"Bendet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ","volume":"89","author":"Kershaw EE","year":"2004","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1365-2265.2006.02474.x","article-title":"The endocrine 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