{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:18:33Z","timestamp":1781795913239,"version":"3.54.5"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>OBJECTIVE: To describe the characteristics of normocalcemic primary hyperparathyroidism (NPHPT) in patients seen for osteoporosis evaluation. PATIENTS AND METHODS: We examined the records of 156 women who came to the hospital to be screened for osteoporosis. Measurements of total calcium, PTH, 25-hydroxy vitamin D, and \u03b2-C-telopeptide were recorded. Bone mineral density and T-scores were evaluated by densitometry of the lumbar spine, femoral neck and distal one-third of the radius. The latter was only measured in patients with primary hyperparathyroidism. Nephrolithiasis and bone fractures were documented by a review of the medical records. RESULTS: We identified 14 patients with NPHPT, accounting for 8.9% of the population studied. In the medical records, the occurrence of kidney stones was reported in 28.6% of the patients with NPHPT, in contrast with only 0.7% of the noncarriers. Regarding the presence of general fractures, 21.4% of the patients with NPHPT were affected versus 16.2% of noncarriers. CONCLUSION: Data from our study suggest that NPHPT has a diverse phenotypic presentation, implying that this may not be an \"indolent\" disease.<\/jats:p>","DOI":"10.1590\/s0004-27302011000500003","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T11:44:10Z","timestamp":1314618250000},"page":"314-317","source":"Crossref","is-referenced-by-count":55,"title":["Normocalcemic primary hyperparathyroidism in clinical practice: an indolent condition or a silent threat?"],"prefix":"10.1590","volume":"55","author":[{"given":"Thyciara Fontenele","family":"Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"R\u00eago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Griz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"1075","article-title":"Primary hyperparathyroidism","author":"Silverberg 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Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0039-6060(97)90357-3","article-title":"Population based screening for primary hyperparathyroidism with serum calcium and parathyroid hormone values in menopausal women","volume":"121","author":"Lundgren E","year":"1997","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"issue":"suppl 2","key":"ref5","first-page":"57","article-title":"Asymptomatic primary hyperparathyroidism: new issues and new questions bridging the past with the future","volume":"17","author":"Bilezikian JP","year":"2002","journal-title":"J Bone Miner Res","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"ref6","first-page":"173","article-title":"High prevalence of normal total calcium and intact PTH in 60 patients with proven primary hyperparathyroidism","volume":"2","author":"Glendenning P","year":"1998","journal-title":"Aust N Z J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0004-8291","issn-type":"print"},{"key":"ref7","first-page":"1137","article-title":"A comparative study of serum ultrafiltrable, ionized, and total calcium in the diagnosis of primary hyperparathyroidism in patients with intermittent or no elevation in total calcium","volume":"04","author":"Forster J","year":"1988","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"key":"ref8","first-page":"75","article-title":"Serum ionized calcium and parathyroid hormone in renal stone disease","volume":"45","author":"Muldowney FP","year":"1976","journal-title":"Q J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0033-5622","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1210\/jcem-67-6-1294","article-title":"Lack of biochemical progression or continuation of accelerated bone loss in mild asymptomatic primary hyperparathyroidism","volume":"67","author":"Rao DS","year":"1988","journal-title":"J Clin Endocrinol Metab","ISSN":"https:\/\/id.crossref.org\/issn\/0021-972X","issn-type":"print"},{"issue":"Suppl 2","key":"ref10","first-page":"97","article-title":"Asymptomatic primary hyperparathyroidism discovered by multichannel biochemical screening: clinical course and considerations bearing on the need for surgical intervention","volume":"6","author":"Parfitt AM","year":"1991","journal-title":"J Bone Miner Res","ISSN":"https:\/\/id.crossref.org\/issn\/0884-0431","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199910213411701","article-title":"A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery","volume":"341","author":"Silverberg SJ","year":"1999","journal-title":"N Engl J 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Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v55n5\/a03v55n5.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T19:37:33Z","timestamp":1495827453000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302011000500003&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0004-27302011000500003"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302011000500003","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}