{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:24:36Z","timestamp":1791444276620,"version":"4.3.3"},"reference-count":47,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>O craniofaringioma \u00e9 uma neoplasia de natureza benigna, pouco frequente, respons\u00e1vel por 1% a 3% de todos os tumores intracranianos, sendo a mais frequente neoplasia intracraniana n\u00e3o neuroepitelial na crian\u00e7a. Geralmente o tumor \u00e9 restrito \u00e0 regi\u00e3o selar e ao III ventr\u00edculo, mas, em decorr\u00eancia da infiltra\u00e7\u00e3o e frequente ader\u00eancia ao sistema nervoso central, apresenta comportamento cl\u00ednico muitas vezes desfavor\u00e1vel, sendo classificado pela Organiza\u00e7\u00e3o Mundial de Sa\u00fade (OMS) como grau I, caracterizado como tumor de baixo ou incerto potencial de maligniza\u00e7\u00e3o. As sequelas endocrinol\u00f3gicas ganham destaque devido ao importante impacto na qualidade de vida dos pacientes, na maioria das vezes crian\u00e7as. O hipopituitarismo e a obesidade hipotal\u00e2mica s\u00e3o complica\u00e7\u00f5es frequentes, sendo o tratamento desse tumor um grande desafio para endocrinologistas e neurocirurgi\u00f5es. A combina\u00e7\u00e3o da cirurgia, radioterapia e aplica\u00e7\u00e3o de drogas e radiois\u00f3topos intratumorais tem como objetivo maximizar as chances de cura e tentar minimizar as sequelas p\u00f3s-operat\u00f3rias, mas, mesmo assim, a recidiva ainda \u00e9 frequente. A escolha da modalidade de tratamento mais adequado para os craniofaringiomas \u00e9 uma decis\u00e3o dif\u00edcil e que deve sempre ser individualizada para cada paciente. Com o objetivo de explorar as m\u00faltiplas op\u00e7\u00f5es terap\u00eauticas para o craniofaringioma, foi realizada revis\u00e3o na literatura com \u00eanfase nas possibilidades terap\u00eauticas e complica\u00e7\u00f5es inerentes ao tratamento dessa patologia.<\/jats:p>","DOI":"10.1590\/s0004-27302011000800004","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T20:39:20Z","timestamp":1490992760000},"page":"520-527","source":"Crossref","is-referenced-by-count":2,"title":["Atualiza\u00e7\u00e3o terap\u00eautica no tratamento dos craniofaringiomas"],"prefix":"10.1590","volume":"55","author":[{"given":"Maria Alice Neves","family":"Bordallo","sequence":"first","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brasil; Instituto Nacional do C\u00e2ncer,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Martins","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade do Estado do 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