{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:57:47Z","timestamp":1762505867035},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>INTRODUCTION: Neonatal cholestasis due to endocrine diseases is infrequent and poorly reco-gnized. Referral to the pediatric endocrinologist is delayed. OBJECTIVE: We characterized cholestasis in infants with congenital pituitary hormone deficiencies (CPHD), and its resolution after hormone replacement therapy (HRT). SUBJECTS AND METHODS: Sixteen patients (12 males) were included; eleven with CPHD, and five with isolated central hypocortisolism. RESULTS: Onset of cholestasis occurred at a median age of 18 days of life (range 2-120). Ten and nine patients had elevated transaminases and \u03b3GT, respectively. Referral to the endocrinologist occurred at 32 days (range 1 - 72). Remission of cholestasis occurred at a median age of 65 days, whereas liver enzymes occurred at 90 days. In our cohort isolated, hypocortisolism was a transient disorder. CONCLUSION: Cholestasis due to hormonal deficiencies completely resolved upon introduction of HRT. Isolated hypocortisolism may be a transient cause of cholestasis that needs to be re-evaluated after remission of cholestasis.<\/jats:p>","DOI":"10.1590\/s0004-27302011000800017","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T07:55:34Z","timestamp":1325663734000},"page":"622-627","source":"Crossref","is-referenced-by-count":20,"title":["Neonatal cholestasis in congenital pituitary hormone deficiency and isolated hypocortisolism: characterization of liver dysfunction and follow-up"],"prefix":"10.1590","volume":"55","author":[{"given":"D\u00e9bora","family":"Braslavsky","sequence":"first","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Keselman","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Galoppo","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Lezama","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Galoppo","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Bergad\u00e1","sequence":"additional","affiliation":[{"name":"Hospital de Ni\u00f1os Dr. Ricardo 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