{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:27:19Z","timestamp":1760189239392},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>INTRODUCTION: Patients with Down syndrome (DS) often have elevated TSH (hypothalamic origin), which is called TSH neurosecretory dysfunction (TSH-nd). In these cases, there is slight elevation in TSH (5-15 \u00b5UI\/mL), with normal free T4 and negative thyroid antibodies (AB). OBJECTIVE: To recognize the risk of progression to Hashimoto's thyroiditis (HT). SUBJECTS AND METHODS: We retrospectively analyzed 40 DS patients (mean age = 4.5 years), followed up for 6.8 years. RESULTS: HT was diagnosed in 9\/40 patients, three early in monitoring, and six during evolution. In 31\/40 patients, TSH-nd diagnosis remained unchanged over the years, with maximum TSH values ranging from 5 to 15 \u00b5UI\/mL. In this group, free T4 also remained normal and AB were negative. There was a significant TSH reduction (p = 0.017), and normal TSH concentrations (&lt; 5.0 \u00b5UI\/mL) were observed in 29\/31 patients, in at least one moment. No patient had TSH &gt; 15 \u00b5UI\/mL. CONCLUSION: DS patients with TSH-nd present low risk of progression to HT (10% for females and 6% for males).<\/jats:p>","DOI":"10.1590\/s0004-27302011000800018","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T07:55:33Z","timestamp":1325663733000},"page":"628-631","source":"Crossref","is-referenced-by-count":10,"title":["TSH neurosecretory dysfunction (TSH-nd) in Down syndrome (DS): low risk of progression to Hashimoto's thyroiditis"],"prefix":"10.1590","volume":"55","author":[{"given":"Claudia Dutra Costantin","family":"Faria","sequence":"first","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane","family":"Kochi","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil; Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryane Pereira Neves da","family":"Silva","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Natalia Freire","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian Teixeira","family":"Mar\u00e7al","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe Henrique Yyazawa","family":"Santos","sequence":"additional","affiliation":[{"name":"Santa 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