{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:39:35Z","timestamp":1790779175516,"version":"4.1.0"},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>INTRODUCTION: Intrinsic limitations of glucocorticoid therapy in patients with congenital adrenal hyperplasia (CAH) determine frequent loss in final height. The association of secondary central precocious puberty and early epiphyseal fusion is also frequent. In these conditions, GnRHa treatment alone or in combination with GH has been indicated. OBJECTIVES: This is a retrospective study, describing the estatural findings of CAH patients with significant decrease in height prediction, who were submitted to combined GH plus GnRHa therapy up to near-final height. SUBJECTS AND METHODS: We studied 13 patients, eight females and five males, eight with the classical and five with the nonclassical form of the disorder. Treatment with hydrocortisone (10-20 mg\/m\u00b2\/day) or prednisolone (3-6 mg\/kg\/day) was associated with GnRHa (3.75 mg\/months) for 4.0 (1.5) years, and GH (0.05 mg\/kg\/day) for 3.6 (1.4) years. RESULTS: Stature standard deviation score for bone age improved significantly after GH treatment, becoming similar to target height at the end of the second year of GH treatment. CONCLUSION: We conclude that combined GH plus GnRHa therapy can be useful in a subset of CAH patients with significant reduction of predicted final height associated with poor hormonal control and central precocious puberty.<\/jats:p>","DOI":"10.1590\/s0004-27302011000800023","type":"journal-article","created":{"date-parts":[[2012,1,4]],"date-time":"2012-01-04T07:56:03Z","timestamp":1325663763000},"page":"661-664","source":"Crossref","is-referenced-by-count":12,"title":["Near-final height in patients with congenital adrenal hyperplasia treated with combined therapy using GH and GnRHa"],"prefix":"10.1590","volume":"55","author":[{"given":"Carlos Alberto","family":"Longui","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Kochi","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Eduardo Proc\u00f3pio","family":"Calliari","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Barcellos Rosa","family":"Modkovski","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Soares","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rica Ferreira","family":"Alves","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Vilas Boas","family":"Prudente","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osmar","family":"Monte","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1067\/mpd.2001.110527","article-title":"Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency: a meta-analysis","volume":"138","author":"Eugster EA","year":"2001","journal-title":"J Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3476","issn-type":"print"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1210\/jc.2009-2616","article-title":"Clinical review: adult height in patients with congenital adrenal hyperplasia: a 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