{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:24:58Z","timestamp":1761895498551},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p>A doen\u00e7a de Cushing (DC) permanece um desafio m\u00e9dico com muitas quest\u00f5es ainda n\u00e3o respondidas. O sucesso terap\u00eautico dos pacientes com DC est\u00e1 ligado \u00e0 correta investiga\u00e7\u00e3o do diagn\u00f3stico s\u00edndr\u00f4mico e etiol\u00f3gico, al\u00e9m da experi\u00eancia e talento do neurocirurgi\u00e3o. A adenomectomia hipofis\u00e1ria transesfenoidal constitui-se no tratamento de escolha para a DC. A avalia\u00e7\u00e3o da remiss\u00e3o da doen\u00e7a no p\u00f3s-operat\u00f3rio e da recorr\u00eancia em longo prazo constitui um desafio ainda maior. Especial destaque deve ser dado para o cortisol s\u00e9rico no p\u00f3s-operat\u00f3rio como marcador de remiss\u00e3o. Adicionalmente, o uso de corticoide ex\u00f3geno no p\u00f3s-operat\u00f3rio apenas em vig\u00eancia de insufici\u00eancia adrenal tem sido sugerido por alguns autores como requisito essencial para permitir a correta interpreta\u00e7\u00e3o do cortisol s\u00e9rico nesse cen\u00e1rio. Neste artigo, revisamos as formas de avalia\u00e7\u00e3o da atividade da DC e os marcadores de remiss\u00e3o e recidiva da DC ap\u00f3s a realiza\u00e7\u00e3o da cirurgia transesfenoidal.<\/jats:p>","DOI":"10.1590\/s0004-27302012000300002","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T13:19:44Z","timestamp":1338815984000},"page":"159-167","source":"Crossref","is-referenced-by-count":4,"title":["Avalia\u00e7\u00e3o do eixo hipot\u00e1lamo-hip\u00f3fise adrenal no diagn\u00f3stico e na remiss\u00e3o da doen\u00e7a de Cushing"],"prefix":"10.1590","volume":"56","author":[{"given":"Fab\u00edola","family":"Costenaro","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul (UFRGS)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ticiana C.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul (UFRGS); Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme A. 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