{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:04:19Z","timestamp":1794330259487,"version":"4.9.0"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>A 19-year-old female with type 1 diabetes for four years, and a 73-year-old female with type 2 diabetes for twenty years developed sudden-onset nephrotic syndrome. Examination by light microscopy, immunofluorescence, and electron microscopy (in one case) identified minimal change disease (MCD) in both cases. There was a potential causative drug (meloxicam) for the 73-year-old patient. Both patients were treated with prednisone and responded with complete remission. The patient with type 1 diabetes showed complete remission without relapse, and the patient with type 2 diabetes had two relapses; complete remission was sustained after associated treatment with cyclophosphamide and prednisone. Both patients had two years of follow-up evaluation after remission. We discuss the outcomes of both patients and emphasize the role of kidney biopsy in diabetic patients with an atypical proteinuric clinical course, because patients with MCD clearly respond to corticotherapy alone or in conjunction with other immunosuppressive agents.<\/jats:p>","DOI":"10.1590\/s0004-27302012000500009","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T07:53:46Z","timestamp":1345276426000},"page":"331-335","source":"Crossref","is-referenced-by-count":6,"title":["Minimal change disease associated with type 1 and type 2 diabetes mellitus"],"prefix":"10.1590","volume":"56","author":[{"given":"Miguel","family":"Moyses Neto","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Servi\u00e7o de Nefrologia de Ribeir\u00e3o Preto,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyl Eanes Barros","family":"Silva","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto S.","family":"Costa","sequence":"additional","affiliation":[{"name":"USP,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elen A.","family":"Rom\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo Merege","family":"Vieira Neto","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Servi\u00e7o de Nefrologia de Ribeir\u00e3o Preto,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio","family":"Dantas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/ajkd.2002.31988","article-title":"Different patterns of renal 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