{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:32:30Z","timestamp":1764603150192},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:p>Icter\u00edcia relacionada \u00e0 tireotoxicose, e n\u00e3o como efeito das drogas antitireoidianas, \u00e9 uma complica\u00e7\u00e3o rara que, em geral, ocorre na presen\u00e7a de insufici\u00eancia card\u00edaca (IC) ou hepatite. Apresentamos o caso de mulher de 54 anos de idade, branca, diagn\u00f3stico de hipertireoidismo por doen\u00e7a de Graves com icter\u00edcia associada a despeito da suspens\u00e3o pr\u00e9via de metimazol. A bilirrubina oscilava em valores elevados entre 30,0 e 52,3 mg\/dL, as transaminases eram pouco elevadas com valores de ALT, na admiss\u00e3o, de 46 U\/I e AST de 87 U\/I; coagulograma e prote\u00ednas encontravam-se no limite inferior da normalidade, sendo TAP 68% e albumina = 2,5 g\/dL. Sorologias para hepatites foram negativas. Ap\u00f3s a primeira dose de radioiodoterapia (RT), a bilirrubina atingiu seu valor m\u00e1ximo, que coincidiu com per\u00edodo de pior exacerba\u00e7\u00e3o da IC. A bilirrubina normalizou-se ap\u00f3s quatro semanas da segunda dose de RT com a estabiliza\u00e7\u00e3o da IC e a normaliza\u00e7\u00e3o dos horm\u00f4nios tireoidianos. Discutimos as poss\u00edveis etiologias de icter\u00edcia severa em pacientes hipertireoideos, assim como a dif\u00edcil terapia anticoagulante com varfarina.<\/jats:p>","DOI":"10.1590\/s0004-27302012000700008","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T08:37:34Z","timestamp":1351327054000},"page":"456-460","source":"Crossref","is-referenced-by-count":1,"title":["Icter\u00edcia grave e miocardiopatia tireot\u00f3xica com trombo atrial"],"prefix":"10.1590","volume":"56","author":[{"given":"Marcus V. 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