{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:23:05Z","timestamp":1765545785146},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Bras Endocrinol Metab"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p>Virilising ovarian tumours are a rare cause of hyperandrogenism in women, accounting for less than 5% of all ovarian neoplasms. It occurs most often in - and postmenopausal women. We report a case of a 64 year-old woman with signs of virilisation that had started 3 years before. Blood hormone analysis revealed increased levels of testosterone, and 17-hydroxyprogesterone. The tetracosactin test revealed 21-hydroxylase deficiency. Radiological imaging demonstrated a nodule in her left ovary. The patient was submitted to bilateral laparoscopic oophorectomy, and histopathological examination revealed a luteoma of the left ovary. Postoperative serum testosterone level and 17-hydroxyprogesterone returned to normal levels in one month. Virilism regressed within six months. Our patient also showed an elevation in 17-OHP serum levels. Normalization of 17-OHP after oophorectomy suggests a case of intratumoral 21-hydroxylase deficiency. To our knowledge, this is the first description of ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal woman. Arq Bras Endocrinol Metab. 2012;56(9):672-6<\/jats:p>","DOI":"10.1590\/s0004-27302012000900012","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T08:25:46Z","timestamp":1358324746000},"page":"672-676","source":"Crossref","is-referenced-by-count":5,"title":["Ovarian intratumoral 21-hydroxylase deficiency in a postmenopausal hirsute woman"],"prefix":"10.1590","volume":"56","author":[{"given":"Selma B.","family":"Souto","sequence":"first","affiliation":[{"name":"University of Porto,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro V.","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro F.","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Braga","sequence":"additional","affiliation":[{"name":"University of Porto,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"University of Porto,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","first-page":"314","article-title":"[Endocrine-active tumors of the ovary]","volume":"24","author":"Stegner HE","year":"2003","journal-title":"Pathologe."},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/PL00007485","article-title":"Ovarian thecoma with ascites and high serum levels of CA125","volume":"264","author":"Takemori M","year":"2000","journal-title":"Arch Gynecol Obstet."},{"key":"ref3","first-page":"987895","article-title":"Ovarian steroid cell tumour: correlation of histopathology with clinicopathologic features","author":"Mehdi G","year":"2011","journal-title":"Patholog Res Int."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1097\/PAS.0b013e31820acb89","article-title":"Perspectives on pure ovarian stromal neoplasms and tumor-like proliferations of the ovarian stroma","volume":"35","author":"Roth LM","year":"2011","journal-title":"Am J Surg Pathol."},{"issue":"3 Pt 2","key":"ref5","first-page":"502","article-title":"Steroid secretion by a virilizing lipoid cell ovarian tumor: origins of dehydroepiandrosterone sulfate","volume":"74","author":"Shenker Y","year":"1989","journal-title":"Obstet Gynecol."},{"key":"ref6","series-title":"Greenspan's basic & clinical endocrinology","first-page":"534","author":"David G","year":"2007","edition":"8"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0720-048X(96)01133-3","article-title":"Steroid cell tumors of the ovary: clinical, ultrasonic, and MRI diagnosis--a case report","volume":"26","author":"Wang PH","year":"1998","journal-title":"Eur J Radiol."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"7521","DOI":"10.1186\/1757-1626-0002-0000007521","article-title":"Virilizing ovarian steroid cell tumor in a 40 year old South Indian female: a case report","volume":"2","author":"Salim S","year":"2009","journal-title":"Cases J."},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1515\/JPEM.1999.12.2.221","article-title":"Severe virilization in a girl with a steroid cell tumor of the ovary","volume":"12","author":"Snyder D","year":"1999","journal-title":"J Pediatr Endocrinol Metab."}],"container-title":["Arquivos Brasileiros de Endocrinologia &amp; Metabologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/abem\/v56n9\/12.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:30:15Z","timestamp":1495884615000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-27302012000900012&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":9,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0004-27302012000900012"],"URL":"https:\/\/doi.org\/10.1590\/s0004-27302012000900012","relation":{},"ISSN":["0004-2730"],"issn-type":[{"value":"0004-2730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}