{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:02:24Z","timestamp":1778598144422,"version":"3.51.4"},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND Small intestine bacterial overgrowth is a heterogeneous syndrome characterized by an increase in the number and\/or the presence of atypical microbiota in the small intestine. The symptoms of small intestine bacterial overgrowth are unspecific, encompassing abdominal pain\/distension, diarrhea and flatulence. Due to the increased cost and complexity for carrying out the jejunal aspirate, the gold standard for diagnosis of the syndrome, routinely the hydrogen (H 2 ) breath test has been used, utilizing glucose or lactulose as substrate, which is able to determine, in the exhaled air, the H 2 concentration produced from the intestinal bacterial metabolism. However, due to a number of individuals presenting a methanogenic microbiota, which does not produce H 2 , the testing on devices capable of detecting, concurrently, the concentration of exhaled H 2 and methane (CH 4 ) is justified.  OBJECTIVE This study aimed to determine the prevalence of small intestine bacterial overgrowth in patients with digestive symptoms, through a comparative analysis of breath tests of H 2 or H 2 and CH 4 associated, using glucose as substrate .  METHODS A total of 200 patients of both sexes without age limitation were evaluated, being directed to a Breath Test Laboratory for performing the H 2 test (100 patients) and of exhaled H 2 and CH 4 (100 patients) due to gastrointestinal complaints, most of them patients with gastrointestinal functional disorders.  RESULTS The results indicated a significant prevalence of small intestine bacterial overgrowth in the H 2 test and in the test of exhaled H 2 and CH 4 (56% and 64% respectively) in patients with gastrointestinal symptoms, and higher prevalence in females. It found further that methane gas was alone responsible for positivity in 18% of patients.  CONCLUSION The data found in this study is consistent with the findings of the current literature and underscores the need for using devices capable of capturing the two gases (exhaled H 2 and CH 4 ) to improve the sensitivity and hence the accuracy of small intestine bacterial overgrowth diagnosis in daily medical practice.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-06","type":"journal-article","created":{"date-parts":[[2017,3,4]],"date-time":"2017-03-04T04:52:36Z","timestamp":1488603156000},"page":"91-95","source":"Crossref","is-referenced-by-count":8,"title":["PREVALENCE OF SMALL INTESTINE BACTERIAL OVERGROWTH IN PATIENTS WITH GASTROINTESTINAL SYMPTOMS"],"prefix":"10.1590","volume":"54","author":[{"given":"Carolina Piedade","family":"MARTINS","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Henrique Amorim","family":"CHAVES","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Gustavo Bravim de","family":"CASTRO","sequence":"additional","affiliation":[{"name":"Cl\u00ednica CEMAD,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel Cristina","family":"GOMES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Friche","family":"PASSOS","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ajg.2009.655","article-title":"Methanogenic flora is associated 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