{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T17:50:29Z","timestamp":1711821029590},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND  Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach.  OBJECTIVE  The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ing\u00e1-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models.  METHODS  The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol\/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg\/kg. Subsequently, the total lesion area (mm2) and relative lesion area (%) were determined.  RESULTS  The results showed significant gastroprotective activity against the aggressive agents used - ethanol and indomethacin - for all the extracts tested.  CONCLUSION  It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-13","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T08:59:32Z","timestamp":1489654772000},"page":"135-138","source":"Crossref","is-referenced-by-count":4,"title":["SCREENING OF WILD FRUIT TREES WITH GASTROPROTECTIVE ACTIVITY IN DIFFERENT EXPERIMENTAL MODELS"],"prefix":"10.1590","volume":"54","author":[{"given":"Luciane Angela Nottar","family":"NESELLO","sequence":"first","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"CAMPOS","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseane Leandra da","family":"ROSA","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Faloni de","family":"ANDRADE","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdir","family":"CECHINEL FILHO","sequence":"additional","affiliation":[{"name":"Universidade do Vale do Itaja\u00ed,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0305-1978(00)00089-2","article-title":"Flavonoids and other phenolics from the leaves of two Marlierea species (Myrtaceae)","volume":"29","author":"Amaral ACF","year":"2001","journal-title":"Biochem Syst Ecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1590\/S0102-695X2006000300019","article-title":"Composi\u00e7\u00e3o qu\u00edmica do \u00f3leo vol\u00e1til de Myrcianthes nativas da regi\u00e3o sul do Brasil","volume":"16","author":"Apel AM","year":"2006","journal-title":"Rev Bras Farmacogn"},{"key":"ref3","first-page":"586","article-title":"Gastroprotective effect of minocycline in experimentally induced gastric ulcers in rats","volume":"7","author":"Asmari AA","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00210-013-0954-0","article-title":"Evaluation of the gastroprotective activity of the extracts, fractions, and pure compounds obtained from aerial parts of Rubus imperialis in different experimental models","volume":"387","author":"Bert\u00e9 PE","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref5","series-title":"Taxa respirat\u00f3ria em sementes recalcitrantes de Inga vera Willd. 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