{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:13:10Z","timestamp":1793160790166,"version":"4.5.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND Helicobacter pylori (H. pylori) gastric infection is a main cause of inflammatory changes and gastric cancers.  OBJECTIVE  The aim of this study was finding the effects of curcumin on oxidative stress and histological changes in chronic gastritis associated with H. pylori.  METHODS  In a randomized clinical trial, patients were divided into two groups: a standard triple therapy group and triple therapy with curcumin group. Endoscopic and histological examinations were measured for all patients before and after 8 weeks.  RESULTS  Triple therapy with curcumin treatment group significantly decreased malondialdehyde markers, glutathione peroxides and increased total antioxidant capacity of the gastric mucosa at the end of study compared to baseline and triple regimen groups. In addition, the oxidative damage to DNA was significantly decreased in triple therapy with curcumin group at the end of study compared to baseline and compared to triple therapy (P&lt;0.05 for both). Triple therapy group in combination with Curcumin significantly decreased all active, chronic and endoscopic inflammation scores of patients compared to the baseline and triple therapy group (P&lt;0.05 for both). The eradication rate by triple therapy + curcumin was significantly increased compared to triple therapy alone (P&lt;0.05).  CONCLUSION  Curcumin can be a useful supplement to improve chronic inflammation and prevention of carcinogenic changes in patients with chronic gastritis associated by H. pylori.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-18","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T12:55:49Z","timestamp":1494507349000},"page":"177-182","source":"Crossref","is-referenced-by-count":63,"title":["CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION"],"prefix":"10.1590","volume":"54","author":[{"given":"Arezu","family":"JUDAKI","sequence":"first","affiliation":[{"name":"Ilam University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"RAHMANI","sequence":"additional","affiliation":[{"name":"Ilam University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jalil","family":"FEIZI","sequence":"additional","affiliation":[{"name":"Ilam University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khairollah","family":"ASADOLLAHI","sequence":"additional","affiliation":[{"name":"Ilam University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"HAFEZI AHMADI","sequence":"additional","affiliation":[{"name":"Ilam University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cbi.2008.05.003","article-title":"Antioxidant and radical scavenging properties of curcumin","volume":"174","author":"Ak T","year":"2008","journal-title":"Chem Biol Interact"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","article-title":"Bioavailability of curcumin: problems and promises","volume":"4","author":"Anand P","year":"2007","journal-title":"Mol Pharm"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.3390\/molecules16064567","article-title":"Curcumin: an anti-in\ufb02ammatory molecule from a curry spice on the path to cancer treatment","volume":"16","author":"Basnet P","year":"2011","journal-title":"Molecules"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/0006-291X(85)90972-6","article-title":"Cigarette causes single-strand breaks in DNA","volume":"133","author":"Borish ET","year":"1095","journal-title":"Biochem Biophys Res Commun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.phymed.2012.12.007","article-title":"Inhibitory effects of curcumin on gastric cancer cells: a proteomic study of molecular targets","volume":"20","author":"Cai XZ","year":"2013","journal-title":"Phytomedicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.freeradbiomed.2005.12.016","article-title":"Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen","volume":"40","author":"Chattopadhyay I","year":"2006","journal-title":"Free Radic Biol Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0304-3835(98)00312-7","article-title":"Serum antioxidative vitamin levels and lipid peroxidation in gastric carcinoma patients","volume":"136","author":"Choi MA","year":"1999","journal-title":"Cancer Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1128\/AAC.01242-08","article-title":"Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice","volume":"53","author":"De R","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1523-5378.2007.00497.x","article-title":"A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?","volume":"12","author":"Di Mario F","year":"2007","journal-title":"Helicobacter"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1079\/BJN2001477","article-title":"Antioxidant vitamin supplements do not reduce reactive oxygen species activity in Helicobacter pylori gastritis in the short term","volume":"87","author":"Everett SM","year":"2002","journal-title":"Br J Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.fct.2014.04.016","article-title":"Protective effect of curcumin against heavy metals-induced liver damage","volume":"69","author":"Garc\u00eda-Ni\u00f1o WR","year":"2014","journal-title":"Food Chem Toxico"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.5230\/jgc.2015.15.4.246","article-title":"Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process","volume":"15","author":"Jung DH","year":"2015","journal-title":"J Gastric Cancer"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0304-3835(03)00147-2","article-title":"Serum and plasma concentration of oxidant and antioxidants in patients of Helicobacter pylori gastritis and its correlation with gastric cancer","volume":"195","author":"Khanzode SS","year":"2003","journal-title":"Cancer Letters."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1248\/bpb.28.2220","article-title":"Curcuma longa Extract Protects against Gastric Ulcers by Blocking H2 Histamine Receptors. Biol","volume":"28","author":"Kim DC","year":"2005","journal-title":"Pharm. Bull"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.intimp.2010.04.021","article-title":"Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients","volume":"10","author":"Koosirirat C","year":"2010","journal-title":"Int Immunopharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.canlet.2008.03.009","article-title":"Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins","volume":"269","author":"Kunnumakkara AB","year":"2008","journal-title":"Cancer Letters"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.phymed.2008.04.004","article-title":"Ef\ufb01cacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study","volume":"15","author":"Kupcinskas L","year":"2008","journal-title":"Phytomedicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15754","DOI":"10.3390\/ijms150915754","article-title":"Curcumin induced human gastric cancer BGC-823 cells apoptosis by ROS-mediated ASK1-MKK4-JNK stress signaling pathway","volume":"15","author":"Liang T","year":"2014","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4321\/S1130-01082006001000007","article-title":"Helicobacter pylori: its discovery and relevance for medicine","volume":"98","author":"Pajares JM","year":"2006","journal-title":"Rev Esp Enferm Dig"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.humpath.2004.12.008","article-title":"Staging and grading of chronic gastritis","volume":"36","author":"Rugge M","year":"2005","journal-title":"Hum Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/nu7010306","article-title":"Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model","volume":"7","author":"Santos AM","year":"2015","journal-title":"Nutrients"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1523-5378.2009.00686.x","article-title":"Oxidative stress in Helicobacter pylori infection: does supplementation with vitamins C and E increase the eradication rate?","volume":"14","author":"Sezikli M","year":"2009","journal-title":"Helicobacter"},{"key":"ref23","first-page":"53","article-title":"Curcumin Attenuates Gastric Cancer Induced by N -Methyl- N -Nitrosourea and Saturated Sodium Chloride in Rats","volume":"91","author":"Sintara K","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1155\/2001\/367832","article-title":"The updated Sydney system: classification and grading of gastritis at the basis of diagnosis and treatment","volume":"15","author":"Stolte M","year":"2001","journal-title":"Can J Gastroenterol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3748\/wjg.v18.i13.1479","article-title":"Curcumin prevents indomethacin-induced gastropathy in rats","volume":"18","author":"Thong-Ngam D","year":"2012","journal-title":"World J. Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1136\/gut.38.2.171","article-title":"Ascorbic acid and total vitamin C concentration in plasma gastric juice and gastrointestinal mucosa: effects of gastritis and oral supplementation","volume":"38","author":"Waring AJ","year":"1996","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ejphar.2013.08.030","article-title":"Curcumin improves expression of ghrelin through attenuating oxidative stress in gastric tissues of streptozotocin-induced diabetic gastroparesis rats","volume":"718","author":"Xun L","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"976","DOI":"10.3748\/wjg.v11.i7.976","article-title":"Comparison of Helicobacter pylori infection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients","volume":"11","author":"Zhang C","year":"2005","journal-title":"World J Gastroenterol"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v54n3\/0004-2803-ag-s0004280320170000018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T20:27:53Z","timestamp":1520281673000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032017000300177&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,8]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["S0004-28032017000300177"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.201700000-18","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5,8]]}}}