{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T05:03:12Z","timestamp":1748581392878},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND  Celiac disease is a glutten induced enteropathy. Some authors recommended screening celiac in children with constipation. There are studies to evaluate celiac disease in children with constipation. But most of them included children regardless to treatment failure.  OBJECTIVE  The aim of this study was to evaluate frequency of elevated anti TTG in children with constipation after failure to improve during 6 week of appropriate treatment of constipation.  METHODS  In this cross sectional study, 550 children with prolonged constipation were included. Place of study was Pediatric Gastroenterology clinic of Abuzar children\u2019s hospital. Prolonged constipation was defined as a constipation which failed to resolved after 6 weeks of appropriate treatment. Constipation was defined according to ROME III criteria. After parental agreement, 5 mL of blood was obtained. Serum anti TTG level was measure using ELISA method by Orientec kit. Anti TTG&gt;10 was considered positive if IgA was normal. SPSS version 16.0 (Chicago, IL, USA) was used for data analysis. Chi square, t-test, and Mann Whitney test used for data analysis.  RESULTS  In this study 550 children (m=277, f=273) were included. Mean age of the cases was 6.8\u00b12.9 year. Anti TTG antibody level was 5.8\u00b12.8 unit\/mL. Of these case, 42 (7.6%) had positive anti-TTG antibody. Celiac disease was confirmed in 40 cases after histopathology examination.  CONCLUSION  Anti-TTG was positive in 7.6% children with chronic constipation who failed to respond after 6 week of treatment. Another multicenter study with longer follow up period is recommended.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-22","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T12:08:59Z","timestamp":1495454939000},"page":"197-200","source":"Crossref","is-referenced-by-count":5,"title":["ANTI-TTG AMONG CHILDREN WITH CHRONIC FUNCTIONAL CONSTIPATION UNRESPONSIVE TO 6 WEEKS OF TREATMENT OF CONSTIPATION"],"prefix":"10.1590","volume":"54","author":[{"given":"Nooshin","family":"SADJADEI","sequence":"first","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences,  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samaneh","family":"HOSSEINMARDY","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences,  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehran","family":"HAKIMZADEH","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences,  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tahereh","family":"ZIAEI KAJBAF","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences,  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazhir","family":"JAVAHERIZADEH","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical Sciences,  Iran; Ahvaz Jundishapur University of Medical Sciences,  Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3906\/sag-1502-130","article-title":"Celiac disease in children with chronic constipation","volume":"46","author":"Cakir M","year":"2016","journal-title":"Turk J Med Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1155\/2013\/945165","article-title":"Yield and cost of performing screening tests for constipation in children","volume":"27","author":"Chogle A","year":"2013","journal-title":"Can J Gastroenterol"},{"key":"ref3","first-page":"166","article-title":"Frequency of Celiac Disease In Children With Chronic Functional Constipation in Shiraz-Iran","volume":"7","author":"Dehghani SM","year":"2015","journal-title":"Middle East J Dig Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5144\/0256-4947.2013.159","article-title":"Prevalence of celiac disease in healthy Iranian school children","volume":"33","author":"Dehghani SM","year":"2013","journal-title":"Ann Saudi Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1053\/j.gastro.2005.11.065","article-title":"Childhood functional gastrointestinal disorders: neonate\/toddler","volume":"130","author":"Hyman PE","year":"2006","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s13312-010-0175-2","article-title":"Etiology and clinical spectrum of constipation in Indian children","volume":"47","author":"Khanna V","year":"2010","journal-title":"Indian Pediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1097\/MPG.0000000000000887","article-title":"Presenting Pattern of Pediatric Celiac Disease","volume":"62","author":"Khatib M","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"ref8","first-page":"173","article-title":"Celiac disease is overrepresented in patients with constipation","volume":"88","author":"Pelleboer RA","year":"2012","journal-title":"J Pediatr"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1053\/j.gastro.2005.08.063","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"130","author":"Rasquin A","year":"2006","journal-title":"Gastroenterology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers MM","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v54n3\/0004-2803-ag-s0004280320170000022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T20:27:53Z","timestamp":1520281673000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032017000300197&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,18]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,7]]}},"alternative-id":["S0004-28032017000300197"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.201700000-22","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5,18]]}}}