{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T21:55:22Z","timestamp":1782510922230,"version":"3.54.5"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT BACKGROUND - Variceal bleeding has a high mortality among cirrhotics, and screening with endoscopy is indicated at the diagnosis of cirrhosis. Screening with endoscopy implies discomfort, risks and considerable costs. OBJECTIVE - To evaluate platelet count squared\/spleen diameter-aspartate aminotransferase ratio (PS\/SA), as a non-invasive predictor of esophageal varices in cirrhotics. METHODS - This cross-sectional study evaluated cirrhotics for PS\/SA and presence of esophageal varices. Outpatient records of cirrhotic patients were reviewed for the abovementioned data. Sensitivity, specificity, negative and positive predictive values of PS\/SA were calculated. After the univariate analysis, variables with P&lt;0.10 were submitted to a logistic regression. RESULTS - The study included 164 cirrhotics, 59.70% male, with a mean age of 56.7 years. Hepatitis C was the most frequent cause of cirrhosis, being present in 90 patients. Patients were classified as Child-Pugh A in 52.44% and as Child-Pugh B or C in 47.56%. Esophageal varices were present in 72.56% of the patients at endoscopy. PS\/SA, with a cutoff of 3x108, had a sensitivity of 95.80% (confidence interval of 95% - 95%CI=0.92-0.99), a specificity of 22.70% (95%CI=0.10-0.35), a positive predictive value of 77.20% (95%CI=0.70-0.84) and a negative predictive value of 66.70% (95%CI=0.42-0.91). In the logistic regression, only platelet count and Child-Pugh score were associated to esophageal varices (P&lt;0.05). CONCLUSION - PS\/SA has an excellent sensitivity to predict esophageal varices, allowing almost one fourth of patients without esophageal varices to spare endoscopy. Nevertheless, PS\/SA is not independently associated to esophageal varices.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-26","type":"journal-article","created":{"date-parts":[[2017,5,28]],"date-time":"2017-05-28T15:23:50Z","timestamp":1495985030000},"page":"222-224","source":"Crossref","is-referenced-by-count":4,"title":["PLATELET COUNT SQUARED\/SPLEEN DIAMETER-ASPARTATE AMINOTRANSFERASE RATIO: NON-INVASIVE METHOD TO PREDICT ESOPHAGEAL VARICES"],"prefix":"10.1590","volume":"54","author":[{"given":"\u00c2ngelo Zambam de","family":"MATTOS","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul, Brazil; Santa Casa de Miseric\u00f3rdia de Porto Alegre, Brazil; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Faraco","family":"DAROS","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo Alves de","family":"MATTOS","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Porto Alegre, Brazil; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/hep.28824","article-title":"Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The \u201cAnticipate\u201d study","volume":"64","author":"Abraldes JG","year":"2016","journal-title":"Hepatology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S68","DOI":"10.1016\/j.jhep.2008.01.021","article-title":"The management of portal hypertension: rational basis, available treatments and future options","volume":"48","author":"Bosch J","year":"2008","journal-title":"J Hepatol"},{"key":"ref3","first-page":"431","article-title":"Platelet count\/spleen diameter ratio to predict the presence of esophageal varices in patients with cirrhosis: a systematic review","volume":"24","author":"Chawla S","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1053\/j.gastro.2012.05.035","article-title":"Measurement of spleen stiffness to evaluate portal hypertension and the presence of esophageal varices in patients with HCV-related cirrhosis","volume":"143","author":"Colecchia A","year":"2012","journal-title":"Gastroenterology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","article-title":"Expanding consensus in portal hypertension: Report of the Baveno VI Consensus Workshop: Stratifying risk and individualizing care for portal hypertension","volume":"63","author":"De Franchis R","year":"2015","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2015.04.006","article-title":"EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis","volume":"63","year":"2015","journal-title":"J Hepatol"},{"key":"ref7","first-page":"922","article-title":"Practice Guidelines Committe of the American Association for the Study of Liver Diseases, Practice Parameters Committee of the American College of Gastroenterology. 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