{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:07:58Z","timestamp":1693933678833},"reference-count":22,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT BACKGROUND: Barrett\u2019s esophagus a complication of gastroesophageal reflux disease (GERD) is a precursor of esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma has been increasing in most Western countries. Rio Grande do Sul (RS), the Southernmost state of Brazil has the highest rates of esophageal cancer with low prevalence of esophageal adenocarcinoma. OBJECTIVE: To investigate the prevalence of Barrett\u2019s esophagus among patients underwent to upper gastrointestinal endoscopy in the last 5 years. METHODS: The records of patients underwent upper gastrointestinal endoscopy between 2011 and 2015 were analyzed. Demographic data, GERD symptoms, endoscopic findings, extension and histological diagnosis of columnar epithelia of the esophagus were recorded. Significance among the variables was accessed by chi-square test and Fisher\u2019s exact test with 95% CI. RESULTS: A total of 5996 patients underwent to upper gastrointestinal endoscopy in the period were included. A total of 1769 (30%) patients with GERD symptoms or esophagitis and 107 (1.8%) with columnar lined esophagus were identified. Except for eight patients, the others with columnar lined esophagus had GERD symptoms or esophagitis. Barrett\u2019s esophagus defined by the presence of intestinal metaplasia occurred in 47 patients; 20 (43%) with segments over 3 cm and 27 (57%) with segments shorter than 3 cm. The global prevalence of Barrett\u2019s esophagus was 0.7% and in GERD patients 2.7%. The odds ratio for the occurrence of columnar lined esophagus in patients with GERD was 30 (95%CI=15.37-63.34). The odds ratio for the presence of intestinal metaplasia in long segments was 8 (95%CI=2.83-23.21). CONCLUSION: GERD patients had a risk 30-folds greater to present columnar lined esophagus than patients without GERD symptoms. Long segments of columnar lined esophagus, had a risk eight-folds higher to have Barrett\u2019s esophagus than short segments. Barrett\u2019s esophagus overall prevalence was 0.7%. In GERD patients, the prevalence was 2.7%. Long Barrett\u2019s esophagus represented globally 0.3% and 1.1% in GERD patients.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-45","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T23:41:12Z","timestamp":1505950872000},"page":"305-307","source":"Crossref","is-referenced-by-count":3,"title":["LOW PREVALENCE OF BARRETT\u2019S ESOPHAGUS IN A RISK AREA FOR ESOPHAGEAL CANCER IN SOUTH OF BRAZIL"],"prefix":"10.1590","volume":"54","author":[{"given":"Diego Michelon","family":"DE CARLI","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Faria de","family":"ARAUJO","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Borges","family":"FAGUNDES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil; Universidade Federal de Santa Maria, Brazil; Universidade Federal do Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/PAS.0000000000000350","article-title":"Is carcinoma in columnar-lined esophagus always located adjacent to intestinal metaplasia A histopathologic assessment","volume":"39","author":"Aida J","year":"2015","journal-title":"Am J Surg Pathol"},{"key":"ref2","first-page":"22","article-title":"Incidence and epidemiology of Barrett's epithelium at the Gastrocentro-UNICAMP","volume":"34","author":"Andreolo NA","year":"1997","journal-title":"Arch Gastroentrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0b013e31822a5a2c","article-title":"Columnar-lined esophagus without intestinal metaplasia has no proven risk of adenocarcinoma","volume":"36","author":"Chandrasoma P","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1097\/PAS.0b013e3181f06990","article-title":"The histologic squamo-oxyntic gap an accurate and reproducible diagnostic marker of gastroesophageal reflux disease","volume":"34","author":"Chandrasoma P","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1097\/00000478-200109000-00010","article-title":"Distribution and significance of epithelial types in columnar-lined esophagus","volume":"25","author":"Chandrasoma PT","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/gutjnl-2011-300730","article-title":"The incidence of oesophageal adenocarcinoma in non-dysplastic Barrett's oesophagus a meta-analysis","volume":"61","author":"Desai TK","year":"2012","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1442-2050.2003.00288.x","article-title":"Intestinal metaplasia in the distal esophagus and correlation with symptoms of gastroesophageal reflux disease","volume":"16","author":"Dietz J","year":"2003","journal-title":"Dis Esophagus"},{"key":"ref8","article-title":"Does the Incidence of Adenocarcinoma of the Esophagus and Gastric Cardia Continue to Rise in the Twenty-First Century?-a SEER Database Analysis","author":"Dubecz A","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/dote.12350","article-title":"Unchanging pattern of prevalence of esophageal cancer, overall and by histological subtype, in the endoscopy service of the main referral hospital in the central region of Rio Grande do Sul State, in Southern Brazil","volume":"29","author":"Fagundes RB","year":"2016","journal-title":"Dis Esophagus"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s10620-008-0395-7","article-title":"Prevalence of Barrett's esophagus in patients with or without GERD symptoms role of race, age, and gender","volume":"54","author":"Fan X","year":"2009","journal-title":"Dig Dis Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1136\/gutjnl-2013-305372","article-title":"British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus","volume":"63","author":"Fitzgerald RC","year":"2014","journal-title":"Gut"},{"key":"ref12","first-page":"46","article-title":"Preval\u00eancia do es\u00f4fago de Barrett em indiv\u00edduos sem sintomas t\u00edpicos da doen\u00e7a por refluxo gastroesof\u00e1gico","volume":"45","author":"Freitas MC","year":"2008","journal-title":"Arq Gastroenterol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/modpathol.2014.125","article-title":"Current issues in Barrett's esophagus and Barrett's-related dysplasia","volume":"28","author":"Goldblum JR","year":"2015","journal-title":"Mod Pathol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1111\/j.1440-1746.2008.05572.x","article-title":"Changing trends in the proportion of adenocarcinoma of the esophagogastric junction in a large tertiary referral center in Japan","volume":"23","author":"Kusano C","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1590\/S0004-28032003000100007","article-title":"[Prevalence of heartburn in Pelotas, RS, Brasil: population-based study]","volume":"40","author":"Nader F","year":"2003","journal-title":"Arq Gastroenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1053\/j.gastro.2005.08.053","article-title":"Prevalence of Barrett's esophagus in the general population an endoscopic study","volume":"129","author":"Ronkainen J","year":"2005","journal-title":"Gastroenterology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1053\/j.gastro.2011.01.031","article-title":"American Gastroenterological Association medical position statement on the management of Barrett's esophagus","volume":"140","author":"Spechler SJ","year":"2011","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJMra1314704","article-title":"Barrett's esophagus","volume":"371","author":"Spechler SJ","year":"2014","journal-title":"N Engl J Med"},{"key":"ref19","first-page":"284","article-title":"[Barrett's esophagus: prevalence and risk factors in the National Hospital Arzobispo Loayza in Lima-Peru]","volume":"30","author":"Vargas C\u00e1rdenas G","year":"2010","journal-title":"Rev Gastroenterol Peru"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.cgh.2012.05.013","article-title":"Effects of dropping the requirement for goblet cells from the diagnosis of Barrett's esophagus","volume":"10","author":"Westerhoff M","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5694\/mja16.00796","article-title":"Barrett's oesophagus epidemiology, diagnosis and clinical management","volume":"205","author":"Whiteman DC","year":"2016","journal-title":"Med J Aust"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.canep.2016.08.002","article-title":"Time trends in the incidence of oesophageal cancer in Asia Variations across populations and histological types","volume":"44","author":"Xie SH","year":"2016","journal-title":"Cancer Epidemiol"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v54n4\/1678-4219-ag-s0004280320170000045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T05:20:21Z","timestamp":1693027221000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032017000400305&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,21]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["S0004-28032017000400305"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.201700000-45","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9,21]]}}}