{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:23:52Z","timestamp":1787239432163,"version":"build-2736575974"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND:  As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions.  OBJECTIVE:  The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center.  METHODS:  The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes.  RESULTS:  The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003). There was no difference between the two groups in terms of the frequencies of HLA-A, HLA-C, HLA-DR, and HLA-DQ antigens.  CONCLUSION:  It was determined that HLA-B*51 plays a critical role in H. pylori infection.<\/jats:p>","DOI":"10.1590\/s0004-2803.201700000-62","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T19:32:25Z","timestamp":1506799945000},"page":"297-299","source":"Crossref","is-referenced-by-count":8,"title":["EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER"],"prefix":"10.1590","volume":"54","author":[{"given":"Sevim","family":"G\u00d6NEN","sequence":"first","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinan","family":"SARI","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u015far","family":"KANDUR","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buket","family":"DALGI\u00c7","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O\u011fuz","family":"S\u00d6YLEMEZO\u011eLU","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2017,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-61779-842-9_14","article-title":"Analytical methods for disease association studies with immunogenetic data","volume":"882","author":"Hollenbach JA","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref2","first-page":"269","article-title":"Association between HLA-DQA1 gene copy number polymorphisms and susceptibility to gastric cancer","volume":"34","author":"Huang LM","year":"2012","journal-title":"Zhonghua Zhong 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