{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T05:16:15Z","timestamp":1755926175822},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT BACKGROUND: The Amazon region is one of the main endemic areas of hepatitis delta in the world and the only one related to the presence of genotype 3 of the delta virus. OBJECTIVE: To analyze the profile, mortality and survival of cirrhotic patients submitted to liver transplantation for chronic hepatitis delta virus and compare with those transplanted by hepatitis B virus monoinfection. METHODS: Retrospective, observational and descriptive study. From May 2002 to December 2011, 629 liver transplants were performed at the Walter Cant\u00eddio University Hospital, of which 29 patients were transplanted due to cirrhosis caused by chronic delta virus infection and 40 by hepatitis B chronic monoinfection. The variables analyzed were: age, sex, MELD score, Child-Pugh score, upper gastrointestinal bleeding and hepatocellular carcinoma occurrence before the transplantation, perioperative platelet count, mortality and survival. RESULTS: The Delta Group was younger and all came from the Brazilian Amazon Region. Group B presented a higher proportion of male patients (92.5%) compared to Group D (58.6%). The occurrence of upper gastrointestinal bleeding before transplantation, MELD score, and Child-Pugh score did not show statistical differences between groups. The occurrence of hepatocellular carcinoma and mortality were higher in the hepatitis B Group. The survival in 4 years was 95% in the Delta Group and 75% in the B Group, with a statistically significant difference (P=0.034). Patients with hepatitis delta presented more evident thrombocytopenia in the pre-transplantation and in the immediate postoperative period. CONCLUSION: The hepatitis by delta virus patients who underwent liver transplantation were predominantly male, coming from the Brazilian Amazon region and with similar liver function to the hepatitis B virus patients. They had a lower incidence of hepatocellular carcinoma, more marked perioperative thrombocytopenia levels and frequent episodes of upper gastrointestinal bleeding. Patients with hepatitis by delta virus had lower mortality and higher survival than patients with hepatitis B virus.<\/jats:p>","DOI":"10.1590\/s0004-2803.201800000-06","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T19:17:32Z","timestamp":1521055052000},"page":"14-17","source":"Crossref","is-referenced-by-count":7,"title":["LIVER TRANSPLANTATION IN HEPATITIS DELTA: SOUTH AMERICA EXPERIENCE"],"prefix":"10.1590","volume":"55","author":[{"given":"Daniel Souza","family":"LIMA","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brazil; Universidade de Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdon Jos\u00e9","family":"MURAD J\u00daNIOR","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Alencar","family":"BARREIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Cardoso","family":"FERNANDES","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Walter Cant\u00eddio, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Rego","family":"COELHO","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brazil; Universidade Federal do Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Huygens Parente","family":"GARCIA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1, Brazil; Universidade Federal do Cear\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1478-3231.2010.02320.x","article-title":"Hepatitis D virus: an update","volume":"31","author":"Pascarella S","year":"2011","journal-title":"Liver Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0140-6736(10)61931-9","article-title":"Hepatitis delta virus","volume":"378","author":"Hughes SA","year":"2011","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"475","DOI":"10.4269\/ajtmh.2006.75.475","article-title":"HDV genotypes in the Western Brazilian Amazon region: a preliminary report","volume":"75","author":"Parana R","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1399-0012.2006.00636.x","article-title":"Longer survival of liver transplant recipients with hepatitis virus coinfections","volume":"21","author":"Rifai K","year":"2007","journal-title":"Clin. 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