{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T14:47:04Z","timestamp":1794581224972,"version":"4.9.1"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND:  Celiac disease is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Almost all celiac patients carry immune recognition genes coding for HLA-DQ2.5 and DQ8 heterodimers. Over the last few years, great importance has been given to HLA-DQ2.2 as probable predisposing variant, although controversies still exist regarding its relevance.  OBJECTIVE:  The aim of our study was to determine the possible existence of an association between HLA-DQ2.2 and celiac disease in Brazilian children by analyzing the prevalence of the predisposing variants for celiac disease in a representative group of children of a population in which this determination is still missing.  METHODS:  HLA-DQ typing was performed in samples from a group of celiac (n=100) and non-celiac children (n=110). All samples were tested for the presence of the following variants: DQA1*05-DQB1*02 (DQ2.5), DQA1*03-DQB1*03:02 (DQ8) and DQA1*02:01-DQB1*02:02 (DQ2.2). Fisher`s exact test was used for statistical analysis.  RESULTS: In the group of 100 celiac children, 78 (78%) were positive for DQ2, 13 (13 %) were DQ2\/DQ8 and 6 (6%) were DQ8 positives. The HLA-DQ pattern in the 110 non-celiac children was as follows: positive for DQ2 in 33 (29.9%) samples, in 2 (1.8 %) was positive for DQ2\/DQ8 and in 15 (13.6%) was positive for DQ8. We found significant differences between the distribution of some but not all of the analyzed alleles when comparing celiac and non-celiac children.  CONCLUSION: The genotyping of celiac disease HLA-DQ predisposing alleles showed similarities with HLA-DQ patterns found in both European and non-European populations, which may be a reflection of the miscegenation, which gave origin to the current Brazilian population. No significant association was found between DQ2.2 variant and celiac disease in the studied population.<\/jats:p>","DOI":"10.1590\/s0004-2803.201800000-16","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T15:17:09Z","timestamp":1521040629000},"page":"82-85","source":"Crossref","is-referenced-by-count":10,"title":["PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN"],"prefix":"10.1590","volume":"55","author":[{"given":"Nicole","family":"SELLESKI","sequence":"first","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil; Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Malta","family":"ALMEIDA","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Coutinho de","family":"ALMEIDA","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil; Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Beatriz","family":"PRATESI","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil; Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanna Karla de Medeiros","family":"N\u00d3BREGA","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil; Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenora","family":"GANDOLFI","sequence":"additional","affiliation":[{"name":"Universidade de Bras\u00edlia,  Brazil; Universidade de Bras\u00edlia,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra071600","article-title":"Celiac Disease","volume":"357","author":"Green PHR","year":"2007","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/gast.2001.22123","article-title":"Current approaches to diagnosis and treatment of celiac disease: An evolving spectrum","volume":"120","author":"Fasano A","year":"2001","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie V","year":"2011","journal-title":"Annu Rev 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