{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:28:40Z","timestamp":1782318520770,"version":"3.54.5"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  BACKGROUND:  Colorectal cancer is one of the major causes of death worldwide. Many studies have been done on the biology of its formation as well as its treatment in recent years. One of the factors involved in the formation or treatment of this malignancy can be attributed to the microbial flora in the intestine.  OBJECTIVE:  This study investigate the potential preventive effect of Lactobacillus acidophilus and Lactobacillus plantarum in patients with polyps or colorectal cancer (CRC).  METHODS:  A total of 77 samples were selected in the form of three groups including individuals suffering from CRC, polyps and healthy subjects. Genomic DNA of fecal specimens and standard strains were extracted and amplified employing primers targeting of the 16S rRNA gene for initial detection. Absolute Real Time PCR quantification was used to determine the copy of the bacterial expression per gram of feces.  RESULTS:  No significant difference were observed between age and gender in the mentioned groups (P=0.06). The average copy number of Lactobacillus acidophilus shows Significant difference between the healthy group and those with polyps (P&lt;0.0001), the healthy group and those with colorectal cancer (P&lt;0.0001), as well as those with polyps and the colorectal cancer patients (P&lt;0.0001).  CONCLUSION:  These results may indicate that taking Lactobacillus acidophilus in people with a family history of CRC and people with polyps may be a way of preventing, treating or reducing the severity of CRC.<\/jats:p>","DOI":"10.1590\/s0004-2803.201800000-87","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T13:43:58Z","timestamp":1550238238000},"page":"407-411","source":"Crossref","is-referenced-by-count":21,"title":["POTENTIAL PREVENTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND LACTOBACILLUS PLANTARUM IN PATIENTS WITH POLYPS OR COLORECTAL C\u00c2NCER"],"prefix":"10.1590","volume":"55","author":[{"given":"Nazi","family":"ZINATIZADEH","sequence":"first","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"KHALILI","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parviz","family":"FALLAH","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malihe","family":"FARID","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran; Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"GERAVAND","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-0652","authenticated-orcid":false,"given":"Somayeh","family":"YASLIANIFARD","sequence":"additional","affiliation":[{"name":"Alborz University of Medical Sciences,  Iran; Alborz University of Medical Sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.canep.2012.12.007","article-title":"National cancer incidence is estimated using the incidence\/mortality ratio in countries with local incidence data: is this estimation correct?","volume":"37","author":"Uhry Z","year":"2013","journal-title":"Cancer Epidemiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2147\/CIA.S109285","article-title":"Colorectal cancer development and advances in screening","volume":"11","author":"Simon K","year":"2016","journal-title":"Clin Interv Aging"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1002\/1097-0142(197905)43:5<1847::AID-CNCR2820430538>3.0.CO;2-L","article-title":"Adenomatous lesions of the large bowel: an autopsy survey","volume":"43","author":"Rickert RR","year":"1979","journal-title":"Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1177\/2050640617718720","article-title":"Prevalence and risk factors for colorectal adenomas in patients with ulcerative colitis","volume":"6","author":"Gordillo J","year":"2018","journal-title":"United European Gastroenterol J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s10620-016-4381-1","article-title":"Adenoma Prevalence and Distribution Among US Latino Subgroups Undergoing Screening Colonoscopy","volume":"62","author":"Chablani SV","year":"2017","journal-title":"Dig Dis Sci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00384-008-0463-7","article-title":"Prognostic factors in 1,138 Iranian colorectal cancer patients","volume":"23","author":"Moghimi-Dehkordi B","year":"2008","journal-title":"Int J Colorectal Dis"},{"key":"ref7","first-page":"123","article-title":"Colorectal cancer in Iran: an epidemiological study","volume":"9","author":"Azadeh S","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref8","first-page":"130","article-title":"Time trends in the occurrence of major GI cancers in Iran","volume":"6","author":"Yazdizadeh B","year":"2005","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref9","first-page":"519","article-title":"Colorectal cancer risk in relation to genetic polymorphism of cytochrome P450 1A1, 2E1, and glutathione-S-transferase M1 enzymes","volume":"20","author":"Kiss I","year":"2000","journal-title":"Anticancer Research"},{"key":"ref10","first-page":"169","article-title":"Inhibitory effects of lactic acid bacteria (LAB) on the azoxymethane-induced colonic preneoplastic lesions","volume":"38","author":"Lee S-M","year":"2000","journal-title":"J Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala SM","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1158\/1940-6207.CAPR-14-0129","article-title":"The human gut microbiome as a screening tool for colorectal cancer","volume":"7","author":"Zackular JP","year":"2014","journal-title":"Cancer Prev Res (Phila)"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1111\/j.1742-4658.2011.08125.x","article-title":"Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression?","volume":"278","author":"Guerra L","year":"2011","journal-title":"FEBS J"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.3748\/wjg.v23.i42.7505","article-title":"Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease","volume":"23","author":"Cukrowska B","year":"2017","journal-title":"World J Gastroenterol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.nutr.22.011602.092259","article-title":"How host-microbial interactions shape the nutrient environment of the mammalian intestine","volume":"22","author":"Hooper LV","year":"2002","journal-title":"Annu Rev Nutr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"476S","DOI":"10.1093\/ajcn\/73.2.476s","article-title":"Market potential for probiotics","volume":"73","author":"Stanton C","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/ajcn\/71.2.405","article-title":"Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998","volume":"71","author":"de Roos NM","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13258","DOI":"10.3748\/wjg.v20.i37.13258","article-title":"Probiotics against neoplastic transformation of gastric mucosa: effects on cell proliferation and polyamine metabolism","volume":"20","author":"Russo F","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1099\/00221287-148-1-257","article-title":"Determination of bacterial load by real-time PCR using a broad-range (universal) probe and primers set","volume":"148","author":"Nadkarni MA","year":"2002","journal-title":"Microbiology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000380892","article-title":"Gut Microbiota and Colorectal Cancer","volume":"2","author":"Yu YN","year":"2015","journal-title":"Gastrointest Tumors"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","article-title":"Transforming growth factor-beta induces development of the T(H)17 lineage","volume":"441","author":"Mangan PR","year":"2006","journal-title":"Nature"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biochi.2010.02.015","article-title":"Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome","volume":"92","author":"Joly F","year":"2010","journal-title":"Biochimie"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1093\/mutage\/ger071","article-title":"A review of the genetic background and tumour profiling in familial colorectal cancer","volume":"27","author":"van Wezel T","year":"2012","journal-title":"Mutagenesis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/jgh.13840","article-title":"The role of the microbiome and the use of probiotics in gastrointestinal disorders in adults in the Asia-Pacific region - background and recommendations of a regional consensus meeting","volume":"33","author":"Ghoshal UC","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1111\/jgh.13861","article-title":"Update on intestinal microbiota in Crohn\u2019s disease 2017: Mechanisms, clinical application, adverse reactions, and outlook","volume":"32","author":"Shen Z","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/carcin\/20.4.629","article-title":"Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells","volume":"20","author":"Abrahamse SL","year":"1999","journal-title":"Carcinogenesis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.jnutbio.2009.06.001","article-title":"Gastrointestinal microflora, food components and colon cancer prevention","volume":"20","author":"Davis CD","year":"2009","journal-title":"J Nutr Biochem"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v55n4\/1678-4219-ag-55-04-407.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T13:40:59Z","timestamp":1579873259000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032018002400407&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["S0004-28032018002400407"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.201800000-87","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]}}}