{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:36:37Z","timestamp":1790030197803,"version":"4.0.1"},"reference-count":38,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: Data related to SARS-CoV-2 exposure rates in patients with inflammatory bowel diseases (IBD) are scarce. Objective - Our aim was to determine the prevalence of serological markers of SARS-Cov-2 and the predictive factors for positivity in patients with IBD.  Methods: This is a cross-sectional, observational study carried out from May to September 2020. SARS-CoV-2 serological markers were determined using chemiluminescence immunoassay in 233 IBD patients without evidence of COVID-19 symptoms. Patient age was 36.6\u00b111.1 years, 118 patients were male (50.6%), and 63.1% had Crohn\u2019s disease. Patient clinical data were extracted from individual electronic medical records and complemented by a structured interview.  Results: Twenty-six out of the 233 patients with IBD had positive serum markers for SARS-CoV-2 (11.2%). Female sex (P&lt;0.003), extra-intestinal manifestations (P=0.004), use of corticosteroids (P=0.049), and previous contact with individuals with flu-like symptoms (P&lt;0.001) or confirmed diagnosis of COVID-19 (P&lt;0.001), were associated with a significant increased rate of positive SARS-Cov-2 serological markers. No significant difference was observed regarding to adherence to protection measures and positivity of SARS-Cov-2 serological markers (P&gt;0.05).  Conclusion: SARS-CoV-2 previous infection in IBD patients was not that uncommon, and its prevalence was 11.2% in our series. Positivity to SARS-CoV-2 serological markers was associated with female sex, extra-intestinal manifestations, use of corticosteroids, and contact with individuals with suspected or confirmed COVID-19. Studies with longer follow-up periods are needed to confirm these findings.<\/jats:p>","DOI":"10.1590\/s0004-2803.202202000-32","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:26:59Z","timestamp":1657110419000},"page":"170-176","source":"Crossref","is-referenced-by-count":1,"title":["PREVALENCE AND PREDICTIVE FACTORS ASSOCIATED WITH POSITIVITY OF SARS-COV-2 SEROLOGICAL MARKERS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE AT AN IBD REFERRAL CENTER"],"prefix":"10.1590","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7698-6599","authenticated-orcid":false,"given":"Sandro da Costa","family":"FERREIRA","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5566-9284","authenticated-orcid":false,"given":"Rog\u00e9rio Serafim","family":"PARRA","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4440-2023","authenticated-orcid":false,"given":"Marley Ribeiro","family":"FEITOSA","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-0526","authenticated-orcid":false,"given":"Omar","family":"FERES","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5887-8663","authenticated-orcid":false,"given":"Rodrigo de Carvalho","family":"SANTANA","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8599-2410","authenticated-orcid":false,"given":"Luiz Ernesto de Almeida","family":"TRONCON","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa2001017","article-title":"A novel coronavirus from patients with pneumonia in China, 2019","volume":"382","author":"Zhu N","year":"2020","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu F","year":"2020","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang C","year":"2020","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia","volume":"382","author":"Li Q","year":"2020","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(20)30746-7","article-title":"First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment","volume":"395","author":"Leung K","year":"2020","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2020.03.004","article-title":"The SARS-CoV-2 outbreak: What we know","volume":"94","author":"Wu D","year":"2020","journal-title":"Int J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"m1036","DOI":"10.1136\/bmj.m1036","article-title":"Covid-19: WHO declares pandemic because of \u201calarming levels\u201d of spread, severity, and inaction","volume":"368","author":"Mahase E","year":"2020","journal-title":"BMJ"},{"key":"ref8","first-page":"157","article-title":"World Health Organization declares COVID-19 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","journal-title":"Acta Biomed"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1177\/2050640620920157","article-title":"The daily impact of COVID-19 in gastroenterology","volume":"8","author":"Magro F","year":"2020","journal-title":"United Eur Gastroenterol J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1136\/gutjnl-2020-321051","article-title":"COVID-19 in gastroenterology: A clinical perspective","volume":"69","author":"Ong J","year":"2020","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.autrev.2019.03.002","article-title":"Induction and maintenance treatment of inflammatory bowel disease: A comprehensive review","volume":"18","author":"Jeong DY","year":"2019","journal-title":"Autoimmun Rev"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2018.04.012","article-title":"Risk of Serious and Opportunistic Infections Associated With Treatment of Inflammatory Bowel Diseases","volume":"155","author":"Kirchgesner J","year":"2018","journal-title":"Gastroenterology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.3748\/wjg.v20.i43.16014","article-title":"Risk of infections associated with biological treatment in inflammatory bowel disease","volume":"20","author":"Andersen NN","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1093\/ecco-jcc\/jjaa061","article-title":"Are patients with inflammatory bowel disease at increased risk for covid-19 infection?","volume":"14","author":"Monteleone G","year":"2020","journal-title":"J Crohn\u2019s Colitis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1136\/gutjnl-2020-321244","article-title":"British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic","volume":"69","author":"Kennedy NA","year":"2020","journal-title":"Gut"},{"key":"ref16","first-page":"1769","article-title":"Adaptations to the British Society of Gastroenterology guidelines on the management of acute severe UC in the context of the COVID-19 pandemic: A RAND appropriateness panel","volume":"69","author":"Din S","year":"2020","journal-title":"Gut"},{"key":"ref17","first-page":"39","article-title":"COVID-19 quarantine measures are associated with negative social impacts and compromised follow-up care in patients with inflammatory bowel disease in Brazil","volume":"34","author":"Feitosa MR","year":"2021","journal-title":"Ann Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/apt.15779","article-title":"Review Article: Prevention, Diagnosis and Management of COVID-19 in the Inflammatory Bowel Disease Patient","volume":"52","author":"Al-Ani AH","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/ecco-jcc\/jjaa058","article-title":"Inflammatory bowel disease care in the COVID-19 pandemic era: the Humanitas, Milan experience","volume":"14","author":"Fiorino G","year":"2020","journal-title":"J Crohns Colitis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/apt.15804","article-title":"2019 novel coronavirus disease (COVID-19) in patients with inflammatory bowel diseases","volume":"52","author":"Taxonera C","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/ibd\/izaa221","article-title":"Incidence, Clinical Characteristics, and Evolution of SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: A Single-Center Study in Madrid, Spain","volume":"27","author":"Guerra I","year":"2021","journal-title":"Inflamm Bowel Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"Satsangi J","year":"2006","journal-title":"Gut"},{"key":"ref23","article-title":"Antibody tests for identification of current and past infection with SARS-CoV-2.","volume":"6","author":"Deeks JJ","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.cmi.2020.06.019","article-title":"Diagnostic strategies for SARS-CoV-2 infection and interpretation of microbiological results","volume":"26","author":"Caruana G","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"otaa026","DOI":"10.1093\/crocol\/otaa026","article-title":"The Risk of SARS-CoV-2 in Immunosuppressed IBD Patients","volume":"2","author":"Higgins PDR","year":"2020","journal-title":"Crohn\u2019s Colitis 360"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/gutjnl-2020-321411","article-title":"Outcomes of COVID-19 in 79 patients with IBD in Italy: An IG-IBD study","volume":"69","author":"Bezzio C","year":"2020","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1016\/j.cgh.2020.04.071","article-title":"Incidence and Patterns of COVID-19 Among Inflammatory Bowel Disease Patients From the Nancy and Milan Cohorts","volume":"18","author":"Allocca M","year":"2020","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.05.009","article-title":"SARS-CoV-2 Testing, Prevalence, and Predictors of COVID-19 in Patients with Inflammatory Bowel Disease in Northern California","volume":"159","author":"Gubatan J","year":"2020","journal-title":"Gastroenterology"},{"key":"ref29","article-title":"Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Inflammatory Bowel Disease Under Biologic Treatment","volume":"159","author":"Norsa L","year":"2020","journal-title":"Gastroenterology"},{"key":"ref30","series-title":"Relat\u00f3rio final. Avalia\u00e7\u00e3o da preval\u00eancia de marcadores virol\u00f3gicos e sorol\u00f3gicos do SARS-CoV-2 na popula\u00e7\u00e3o de Ribeir\u00e3o Preto: um inqu\u00e9rito epidemiol\u00f3gico","year":"2020"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S2468-1253(20)30076-5","article-title":"Implications of COVID-19 for patients with pre-existing digestive diseases","volume":"5","author":"Mao R","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref32","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.05.032","article-title":"Corticosteroids, But Not TNF Antagonists, Are Associated With Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results From an International Registry","volume":"159","author":"Brenner EJ","year":"2020","journal-title":"Gastroenterology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1053\/j.gastro.2020.04.012","article-title":"AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary","volume":"159","author":"Rubin DT","year":"2020","journal-title":"Gastroenterology"},{"key":"ref34","first-page":"34920","article-title":"The course of Covid 19 in Inflammatory Bowel Disease: protective role of TNF antagonists Response to: Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an Int","volume":"S0016-5085","author":"Cappello M","year":"2020","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2021.09.011","article-title":"Impact of Medications on COVID-19 Outcomes in Inflammatory Bowel isease: Analysis of More Than 6000 Patients From an International Registry: Surveillance Epidemiology of Coronavirus Under Research Exclusion for Inflammatory Bowel Disease (SECURE-IBD) Research Group","volume":"162","author":"Ungaro RC","year":"2022","journal-title":"Gastroenterology"},{"issue":"2021","key":"ref36","first-page":"7591141","article-title":"Clinical Outcomes of COVID-19 and Impact on Disease Course in Patients with Inflammatory Bowel Disease","volume":"30","author":"Wetwittayakhlang P","year":"2021","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"(6)","key":"ref37","article-title":"Performance Evaluation of the Siemens SARS-CoV-2 Total Antibody and IgG Antibody Test","volume":"52","author":"Florin L","year":"2021","journal-title":"Lab Med"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"649781","DOI":"10.3389\/fpubh.2021.649781","article-title":"Seroprevalence of SARS-CoV-2 Assessed by Four Chemiluminescence Immunoassays and One Immunocromatography Test for SARS-Cov-2","volume":"29","author":"Cerino P","year":"2021","journal-title":"Front Public Heal"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["Preval\u00eanc\u0131a e fatores pred\u0131t\u0131vos assoc\u0131ados \u00e0 pos\u0131t\u0131v\u0131dade dos marcadores serol\u00f3g\u0131cos do SARS-COV-2 em pac\u0131entes com doen\u00e7a \u0131nflamat\u00f3r\u0131a \u0131ntest\u0131nal em um centro de refer\u00eanc\u0131a em DII"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032022000200170&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:31:53Z","timestamp":1658842313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032022000200170&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["S0004-28032022000200170"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.202202000-32","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}