{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:09Z","timestamp":1788871869371,"version":"build-2803163510"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: The role of ascitic and serum levels of various tumour biomarkers in the discrimination of cause of ascites is not well established.  Objective: To evaluate the role of serum and ascitic levels of tumor biomarkers (CA 72-4, CA 19-9, CEA and CA 125) in discrimination of cause of ascites.  Methods: A prospective study was conducted in consecutive patients presenting with ascites. Serum and ascitic levels of CA 19-9, CA 125, CA 72-4 and carcinoembryonic antigen (CEA) were determined at the presentation. The patients with cirrhotic ascites, tuberculous peritonitis (TBP) and peritoneal carcinomatosis (PC) were eventually included in analysis.  Results: Of the 93 patients (58 males, mean age 47 years) included, the underlying cause was cirrhosis in 31, PC in 42 and peritoneal tuberculosis in 20. The best cutoff for discriminating benign and malignant ascites for serum CEA, CA 19-9 and CA 72-4 were 6.7 ng\/mL, 108 IU\/mL and 8.9 IU\/mL, respectively. The best cutoff for discriminating benign and malignant ascites for ascitic CA 125, CEA, CA 19-9 and CA 72-4 were 623 IU\/mL, 8.7 ng\/mL, 33.2 IU\/mL and 7 IU\/mL, respectively.  Conclusion: The performance of single biomarker for the prediction of underlying PC is low but a combination of serum CA 19-9 and CA 72-4 best predicted the presence of peritoneal carcinomatosis.<\/jats:p>","DOI":"10.1590\/s0004-2803.202202000-37","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:14:56Z","timestamp":1657109696000},"page":"198-203","source":"Crossref","is-referenced-by-count":8,"title":["ASCITIC AND SERUM LEVELS OF TUMOR BIOMARKERS (CA 72-4, CA 19-9, CEA AND CA 125) IN DISCRIMINATION OF CAUSE OF ASCITES: A PROSPECTIVE STUDY"],"prefix":"10.1590","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4376-5439","authenticated-orcid":false,"given":"Tanvi","family":"JAIN","sequence":"first","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-7308","authenticated-orcid":false,"given":"Sant","family":"RAM","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6721-7605","authenticated-orcid":false,"given":"Hemanth","family":"KUMAR","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9723-6500","authenticated-orcid":false,"given":"Atul","family":"SAROCH","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-3409","authenticated-orcid":false,"given":"Vishal","family":"SHARMA","sequence":"additional","affiliation":[{"name":"Postgraduate Institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0748-9473","authenticated-orcid":false,"given":"Harjeet","family":"SINGH","sequence":"additional","affiliation":[{"name":"Post Graduate institute of Medical Education and Research,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1056\/NEJM199402033300508","article-title":"Care Of Patients With Ascites","volume":"330","author":"Runyon BA","year":"1994","journal-title":"N Engl J Med"},{"key":"ref2","series-title":"Sherlock\u2019s Diseases Of The Liver And Biliary System","first-page":"210","volume-title":"Ascites","author":"Garcia-Tsao G","year":"2011","edition":"11th Ed"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1258\/acb.2010.010048","article-title":"Biochemical Analysis Of Ascitic (Peritoneal) Fluid: What Should We Measure?","volume":"47","author":"Tarn AC","year":"2010","journal-title":"Ann Clin Biochem"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1056\/NEJMra035021","article-title":"Management Of Cirrhosis and Ascites","volume":"350","author":"Gine SP","year":"2004","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/(SICI)1097-0339(199906)20:6<350::AID-DC5>3.0.CO;2-7","article-title":"Diagnostic Accuracy of Effusion Cytology","volume":"20","author":"Motherby H","year":"1999","journal-title":"Diagn Cytopathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/00000658-198606000-00009","article-title":"Malignant Ascites: Clinical and Experimental Observations","volume":"203","author":"Garrison N","year":"1986","journal-title":"Ann Surg"},{"key":"ref7","first-page":"51","article-title":"A Cytological Study on Serous Fluid in Cancer","volume":"27","author":"Tomb J","year":"1974","journal-title":"J med Liban"},{"key":"ref8","first-page":"513","article-title":"Preoperative Prediction of poor prognostic parameters and adjuvant treatment in women with pure endometrioid type endometrial cancer: what is the significance of tumor markers?","volume":"35","author":"Baser E","year":"2014","journal-title":"Eur J Gynaecol Oncol"},{"key":"ref9","first-page":"58","article-title":"Ascitic Fluid Analysis in The Differential Diagnosis of Ascites: Focus on Cirrhotic Ascites","volume":"2","author":"Huang LL","year":"2014","journal-title":"J Clin Transl Hepatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1590\/S0004-28032007000300011","article-title":"CA72-4 Antigen Levels in Serum and Peritoneal Washing In Gastric Cancer. Correlation With Morphological Aspects of Neoplasia","volume":"44","author":"Fernandes L","year":"2001","journal-title":"Arq Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.dld.2017.12.008","article-title":"Serial C-reactive protein measurements in patients treated for suspected abdominal tuberculosis","volume":"50","author":"Sharma V","year":"2017","journal-title":"Dig Liver Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/14787210.2019.1642746","article-title":"Controversies in classification of peritoneal tuberculosis and a proposal for clinico-radiological classification","volume":"17","author":"Ahamed Z R","year":"2019","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.7314\/APJCP.2015.16.2.719","article-title":"Tumor Markers In Serum And Ascites In The Diagnosis Of Benign And Malignant Ascites","volume":"16","author":"Zhu F","year":"2015","journal-title":"Asian Pac J Cancer P"},{"key":"ref14","first-page":"1616","article-title":"The importance of serum and ascites fluid alpha-fetoprotein, carcinoembryonic antigen, CA 19-9, and CA 15-3 levels in differential diagnosis of ascites etiology","volume":"48","author":"Sari R","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"ref15","first-page":"357","article-title":"Evaluation of tumor markers","volume":"13","author":"Liu F","year":"2014","journal-title":"Ann Hepatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1136\/jcp.54.11.831","article-title":"Value of carcinoembryonic antigen (CEA) and cholesterol assays of ascitic \ufb02uid in cases of inconclusive cytology","volume":"54","author":"Guly\u00e1s M","year":"2001","journal-title":"J Clin Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/ijc.2910460320","article-title":"CA 72-4 radioimmunoassay in the diagnosis of malignant effusions. Comparison of various tumor markers","volume":"46","author":"Ferroni P","year":"1990","journal-title":"Int J Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"78068","DOI":"10.18632\/oncotarget.17355","article-title":"Carbohydrate Antigen 125 And Carcinoembryonic Antigen In The Differentiation Of Tuberculous Peritonitis And Peritonitis Carcinomatosa","volume":"8","author":"Huan T","year":"2017","journal-title":"Oncotarget"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1634\/theoncologist.2-5-324","article-title":"Tumor Markers in Ovarian Malignancies","volume":"2","author":"Eagle K","year":"1997","journal-title":"Oncologist"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["N\u00edveis asc\u00edticos e soros de biomarcadores tumorais (CA 72-4, CA 19-9, CEA e CA 125) em discrimina\u00e7\u00e3o de causa de ascites: um estudo prospectivo"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032022000200198&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:32:54Z","timestamp":1658842374000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032022000200198&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":19,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["S0004-28032022000200198"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.202202000-37","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}