{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T18:41:30Z","timestamp":1776883290739,"version":"3.51.2"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: No study has focused on Health-Related Quality of Life (HRQoL) for Chagas Achalasia patients. Objective: To compare HRQoL between Chagas Achalasia patients and the general population; and to correlate HRQoL with clinical factors that can affect it.  Methods: Sixty Chagas Achalasia patients and 50 controls were evaluated. All patients underwent esophageal manometry for the diagnosis of achalasia and esophagogram to determine the grade of megaesophagus. Three questionnaires were used: 1) clinical: the following data were collected: demographic, medical history, body mass index, occurrence of six esophageal symptoms (Esophageal Symptom Score: number of symptoms reported by patients), duration of dysphagia; 2) socio-economic-cultural status evaluation: patients and controls answered seven questions about their socio-economic-cultural conditions; 3) HRQoL: the validated Brazilian-Portuguese version of the Short-form Health Survey (SF-36) questionnaire (license QM020039) was used. It measures health in eight domains: 3a) four physical: physical functioning, role limitations relating to physical health, bodily pain, and general health perception; 3b) four mental: vitality, social functioning, role limitations relating to emotional health, and mental health. These domains can be summarized into Physical and Mental Summary scores. We analyzed correlations between SF-36 Physical\/Mental Summary Component scores and the following clinical factors: Esophageal Symptom Score, duration of dysphagia, body mass index, grades of megaesophagus (defined by the esophagogram) and presence\/absence of megacolon (defined by opaque enema).  Results: Patients and controls had similar age, gender, medical history, and socio-economic-cultural lifestyles (P&gt;0.05). All patients had dysphagia and megaesophagus. SF-36 scores were significantly lower in Chagas Achalasia patients than controls for all eight domains (physicals: P&lt;0.002; mentals: P&lt;0.0027). The Physical and Mental Summary Component scores were also lower in Chagas Achalasia patients than controls (P&lt;0.0062). For patients, the Physical Summary score was negatively correlated to Esophageal Symptom Score (P=0.0011) and positively correlated to body mass index (P=0.02). No other correlations were found.  Conclusion: Chagas Achalasia patients have an impaired HRQoL in all physical and mental domains. Patients reporting more symptoms had worse physical domains. Patients with higher body mass index had better physical domains.<\/jats:p>","DOI":"10.1590\/s0004-2803.202202000-50","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T12:05:50Z","timestamp":1657109150000},"page":"281-287","source":"Crossref","is-referenced-by-count":1,"title":["IMPAIRED QUALITY OF LIFE IN CHAGAS ACALASIA PATIENTS AND ASSOCIATED CLINICAL FACTORS"],"prefix":"10.1590","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-2059","authenticated-orcid":false,"given":"Lucilene","family":"ROSA-E-SILVA","sequence":"first","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7760-5655","authenticated-orcid":false,"given":"Rose Meire Albuquerque","family":"PONTES","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-2198","authenticated-orcid":false,"given":"Grazieli Lopes Matta e","family":"VENDRAME","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-9002","authenticated-orcid":false,"given":"Felipe Augusto Linhares","family":"XAVIER","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-3166","authenticated-orcid":false,"given":"Gabriel Afonso Dutra","family":"KRELING","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3216-7185","authenticated-orcid":false,"given":"Philipe Quagliato","family":"BELLINATI","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"ref1","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates","volume":"90","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"ref2","series-title":"Protozooses Humanas","first-page":"38","volume-title":"Doen\u00e7a de Chagas","author":"Rezende JM","year":"1994"},{"key":"ref3","first-page":"255","article-title":"Chagas disease: a model of denervation in the study of digestive tract motility","volume":"18","author":"Meneghelli UG","year":"1985","journal-title":"Braz J Med Biol Res"},{"key":"ref4","first-page":"1119","article-title":"The spectrum of esophageal motor disorders in Chagas disease","volume":"90","author":"Oliveira 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S\u00e3o Paulo"},{"key":"ref33","article-title":"Sociodemographic factors, level of physical activity and health-related quality of life in adults from the north-east of S\u00e3o Paulo, Brazil: a cross-sectional population study","author":"Maciel NM","year":"2018","journal-title":"BMJ Open"},{"key":"ref34","article-title":"Evaluation of esophageal Achalasia: from symptoms to the Chicago classification","volume":"31","author":"Laurindo-Neto RM","year":"2018","journal-title":"ABCD Arq Bras Cir Dig"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1590\/s0004-2803.202100000-88","article-title":"Symptoms associated with different degrees of megaesophagus in Chagas disease","volume":"58","author":"Oliveira JA","year":"2021","journal-title":"Arq Gastroenterol"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["Comprometimento da qualidade de vida em pacientes com acal\u00e1sia chag\u00e1sica e fatores cl\u00ednicos associados"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032022000200281&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T13:31:00Z","timestamp":1658842260000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032022000200281&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["S0004-28032022000200281"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.202202000-50","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}