{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:44:53Z","timestamp":1784033093536,"version":"3.55.0"},"reference-count":42,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: The role of dairy foods in inflammatory bowel disease (IBD) has been controversial and it is debatable if patients with IBD should avoid milk and dairy products or not, as well as the relationship between these foods and symptoms among those population.  Objective: This multi centric cross-sectional study designed to evaluate if it is really necessary to deprive IBD patients from consumption of dairy foods.  Methods: A multicenter study with 12 gastroenterology referral centers in four countries was designed to evaluate gastrointestinal (GI) symptoms after consumption of dairy foods from all outpatients with IBD during 6 months and to compare patients treated at the same centers without IBD (non IBD cases).  Results: Overall 1888 cases included (872 IBD patients and 1016 non IBD cases). 56.6% of participants were female with average age of 40.1 years. Racially 79.8% participants were Caucasians and originally they were citizens of 10 countries. Relative prevalence of IBD was higher in Africans and Indians and the most frequent prevalence of dairy foods intolerance was seen in Asians. Among IBD patients, 571 cases diagnosed as ulcerative colitis and 189 participants as Crohn\u2019s disease. Average duration of diagnosis as IBD was 6.8 years (from 2 months to 35 years). The most prevalent GI symptoms after consumption of all the dairy foods were bloating and abdominal pain. Totally, intolerance of dairy foods and lactase deficiency was more prevalent among IBD patients in comparison with non IBD cases (65.5% vs 46.1%, P=0.0001). But the rate of GI complains among IBD patients who had not any family history of lactase deficiency, history of food sensitivity or both were 59.91%, 52.87% &amp; 50.33% respectively and similar to non IBD cases (P=0.68, 0.98 &amp; 0.99 respectively).  Conclusion: The rate of dairy foods intolerance among IBD patients without family history of lactase deficiency or history of food sensitivity is similar to non IBD cases and probably there is no reason to deprive them from this important source of dietary calcium, vitamin D and other nutrients.<\/jats:p>","DOI":"10.1590\/s0004-2803.202203000-65","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:31:07Z","timestamp":1662751867000},"page":"358-364","source":"Crossref","is-referenced-by-count":8,"title":["IS DAIRY FOODS RESTRICTION MANDATORY FOR INFLAMMATORY BOWEL DISEASE PATIENTS: A MULTINATIONAL CROSS-SECTIONAL STUDY"],"prefix":"10.1590","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-6151","authenticated-orcid":false,"given":"Pezhman","family":"ALAVINEJAD","sequence":"first","affiliation":[{"name":"Ahvaz Jundishapur University of Medical sciences,  Iran; World Endoscopy Organization,  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3815-9266","authenticated-orcid":false,"given":"Morteza","family":"NAYEBI","sequence":"additional","affiliation":[{"name":"Shahid Rajaie Cardiovascular, Medical & Research Center,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-8759","authenticated-orcid":false,"given":"Abazar","family":"PARSI","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-5608","authenticated-orcid":false,"given":"Farnaz","family":"FARSI","sequence":"additional","affiliation":[{"name":"Iran University of Mediceal Sciences,  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Hussien","family":"AHMED","sequence":"additional","affiliation":[{"name":"Kafrelsheikh University,  Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-6998","authenticated-orcid":false,"given":"Bahman","family":"CHERAGHIAN","sequence":"additional","affiliation":[{"name":"Ahvaz Jundishapur University of Medical sciences,  Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-9496","authenticated-orcid":false,"given":"Dao Viet","family":"HANG","sequence":"additional","affiliation":[{"name":"Hanoi Medical University,  Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3420-5608","authenticated-orcid":false,"given":"Shabnam","family":"SHAHROKH","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Sciences,  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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.gastro.2011.10.001","article-title":"Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review","volume":"142","author":"Molodecky NA","year":"2012","journal-title":"Gastroenterology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","article-title":"Inflammatory bowel disease: the role of environmental factors","volume":"3","author":"Danese S","year":"2004","journal-title":"Autoimmun Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","article-title":"Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences","volume":"126","author":"Loftus Jr 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insufficiently taken into account","volume":"11","author":"Zeitz J","year":"2016","journal-title":"Plos One"},{"key":"ref8","article-title":"Gastrointestinal symptom severity in irritable bowel syndrome, inflammatory bowel disease and the general population","volume":"29","author":"Lee AD","year":"2017","journal-title":"Neurogastroenterol Motil"},{"key":"ref9","first-page":"575","article-title":"Restriction of dairy products; a reality in inflammatory bowel disease patients","volume":"29","author":"Lopes MB","year":"2014","journal-title":"Nutr Hosp"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"110830","DOI":"10.1016\/j.nut.2020.110830","article-title":"Milk and dairy product consumption in patients with inflammatory bowel disease: Helpful or harmful to bone mineral density?","volume":"79","author":"Krela-Ka\u017amierczak I","year":"2020","journal-title":"Nutrition"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12937-016-0183-8","article-title":"Systematic review and meta-analysis of lactose digestion, its impact on intolerance and nutritional effects of dairy food restriction in inflammatory bowel diseases","volume":"15","author":"Szilagyi A","year":"2015","journal-title":"Nutr J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1079\/PHN2002403","article-title":"Consumption of dairy products in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort: data from 35955 24-hour dietary recalls in 10 European countries","volume":"5","author":"Hjart\u00e5ker A","year":"2002","journal-title":"Public Health Nutr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/mnfr.201400569","article-title":"Dairy nutrients and their effect on inflammatory profile in molecular studies","volume":"59","author":"Da Silva MS","year":"2015","journal-title":"Mol Nutr Food Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3945\/ajcn.112.052217","article-title":"Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults","volume":"97","author":"Labonte ME","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/00054725-200502000-00009","article-title":"Dietary risk factors for inflammatory bowel disease A Multicenter Case\u2010Control Study in Japan","volume":"11","author":"Sakamoto N","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/aje\/kwk067","article-title":"A case-control study of drinking water and dairy products in Crohn\u2019s disease-further investigation of the possible role of Mycobacterium avium paratuberculosis","volume":"165","author":"Abubakar I","year":"2007","journal-title":"Am J Epidemiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/ajg.2010.192","article-title":"Animal protein intake and risk of inflammatory bowel disease: The E3N prospective study","volume":"105","author":"Jantchou P","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S2468-1253(17)30154-1","article-title":"Country, regional, and global estimates for lactose malabsorption in adults: a systematic review and meta-analysis","volume":"2","author":"Storhaug CL","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.genet.37.110801.143820","article-title":"Genetics of lactase persistence and lactose intolerance","volume":"37","author":"Swallow DM","year":"2003","journal-title":"Annu Rev 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diseases","volume":"15","author":"Szilagyi A","year":"2015","journal-title":"Nutr J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ajcn\/65.2.564","article-title":"Dairy sensitivity, lactose malabsorption, and elimination diets in inflammatory bowel disease","volume":"65","author":"Mishkin S","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"ref35","first-page":"327","article-title":"Evaluation of lactose and milk intolerance, and bone mineral density in Indian patients with inflammatory bowel disease","volume":"25","author":"Gupta R","year":"2012","journal-title":"Natl Med J India"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0210-5705(03)70396-3","article-title":"Lactose malabsorption in ulcerative colitis. A case-control study","volume":"26","author":"Ginard D","year":"2003","journal-title":"Gastroenterol Hepatol"},{"key":"ref37","first-page":"26","article-title":"Deficient lactose digestion and intolerance in a group of patients with chronic nonspecific ulcerative colitis: a controlled, double-blind, cross-over clinical trial","volume":"77","author":"Cabrera-Acosta GA","year":"2012","journal-title":"Rev Gastroenterol Mex"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MOG.0b013e328353e61e","article-title":"Inflammatory bowel disease pathogenesis: what is new?","volume":"28","author":"Scharl M","year":"2012","journal-title":"Curr Opin Gastroenterol"},{"key":"ref39","first-page":"895","article-title":"Dietary characteristics of patients with inflammatory bowel diseases","volume":"42","author":"Zvirbliene A","year":"2006","journal-title":"Medicina"},{"key":"ref40","first-page":"212","article-title":"Lactose malabsorption in patients with inflammatory bowel disease without activity: would it be necessary to exclude lactose products in the diet of all patients?","volume":"21","author":"Madrid RB","year":"2004","journal-title":"An Med Interna"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"157","DOI":"10.5217\/ir.2019.00038","article-title":"Can vitamin D supplementation help control inflammation in inflammatory bowel disease beyond its classical role in bone health?","volume":"17","author":"Hwang SW","year":"2019","journal-title":"Intest Res"},{"key":"ref42","first-page":"895","article-title":"Dietary characteristics of patients with inflammatory bowel diseases","volume":"42","author":"Zvirbliene A","year":"2006","journal-title":"Medicina"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["A restri\u00e7\u00e3o de alimentos l\u00e1cteos \u00e9 obrigat\u00f3ria para pacientes com doen\u00e7a inflamat\u00f3ria intestinal? Estudo transversal multinacional"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032022000300358&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:31:54Z","timestamp":1662751914000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032022000300358&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["S0004-28032022000300358"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.202203000-65","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}