{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:33Z","timestamp":1740142413780,"version":"3.37.3"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: Colorectal cancer is the third cause of cancer worldwide and a quarter of them are in the rectum. DEK oncogene is involved in several nuclear processes and can accelerate tumorigenesis.  Objective: This study aims to evaluate the immunoexpression of DEK and Phospho-P38 proteins before neoadjuvant therapy in patients with rectum adenocarcinoma and correlate it with a clinical response and survival.  Methods: Patients with adenocarcinoma of the middle and low rectum who underwent chemotherapy and radiotherapy followed by surgical tumor resection were included. The expression and quantification were studied by immunohistochemistry in the tumor biopsy tissues using a HScore system. Score \u22654 were considered positive and those with &lt;4 negative.  Results: 22 patients were included with a mean age of 63.55 years (SD: \u00b113.49). The clinical-stage before treatment was T3 on 72.7%, T4 on 18.2%, 31.8% were N1, 50% N0 and all M0. After chemo and radiotherapy, 54.6% were T3; 22.7% were classified as T2; 9.1% as T1, and 13.6% were T0. Among the tumors, 22.7% were positive for DEK and 63.6% positive for Phospho-P38. There was a positive correlation between DEK protein before treatment and pTNM stage (P=0.011). Phospho-P38 protein showed no correlation with these parameters. Patients with a negative HScore had a mean survival of 141.33 months (95%CI: 112.41-170.25) and those with a positive HSscore had a mean survival of 25.10 months (95%CI: 17.36-32.84; P&lt;0.001).  Conclusion: A higher expression of DEK was observed in advanced stages. Patients who presented DEK expression &lt;4 had a higher survival, being a factor of worst prognosis.<\/jats:p>","DOI":"10.1590\/s0004-2803.202203000-74","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:46:31Z","timestamp":1662752791000},"page":"414-420","source":"Crossref","is-referenced-by-count":0,"title":["IMMUNOEXPRESSION OF DEK AND PHOSPHO-P38 PROTEINS IN RECTAL CANCER BEFORE CHEMORADIATION THERAPY"],"prefix":"10.1590","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5423-8311","authenticated-orcid":false,"given":"Rebeca De Barros","family":"TADOKORO","sequence":"first","affiliation":[{"name":"UNIFESP,  Brasil; UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-4030","authenticated-orcid":false,"given":"Leonardo","family":"CARDILI","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4378-076X","authenticated-orcid":false,"given":"Ricardo","family":"ARTIGIANI NETO","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2349-4686","authenticated-orcid":false,"given":"Ana Paula Ribeiro","family":"PAIOTTI","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3028-7263","authenticated-orcid":false,"given":"Celina Tizuko Fujiyama","family":"OSHIMA","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-0343","authenticated-orcid":false,"given":"Nora Manoukian","family":"FORONES","sequence":"additional","affiliation":[{"name":"UNIFESP,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/ijms18030573","article-title":"Predictive and Prognostic Molecular Biomarkers for Response to Neoadjuvant Chemoradiation in Rectal Cancer","volume":"18","author":"Dayde D","year":"2017","journal-title":"Int J Mol Sci"},{"year":"2020","series-title":"GLOBOCAN Estimates of Incidence and Mortality Worldwide","key":"ref2"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-018-4048-8","article-title":"The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer","volume":"18","author":"Martinez-Useros J","year":"2018","journal-title":"BMC Cancer"},{"key":"ref4","series-title":"International Manual of Oncology Practice: (iMOP) - Principles of Medical 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Dis"},{"key":"ref19","first-page":"1","article-title":"MRI-based radiomics of rectal cancer: preoperative assessment of the pathological features","volume":"19","author":"Ma X","year":"2019","journal-title":"BMC Med Imaging"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"98985","DOI":"10.18632\/oncotarget.19684","article-title":"Prognostic role of DEK in human solid tumors: a meta-analysis","volume":"8","author":"Liu G","year":"2017","journal-title":"Oncotarget"},{"key":"ref21","first-page":"1338","article-title":"DEK promotes the proliferation and invasion of lung cancers and indicates poor prognosis in lung adenocarcinomas","volume":"43","author":"Yang M","year":"2020","journal-title":"Oncol Rep"},{"issue":"9","key":"ref22","first-page":"1","article-title":"High expression of DEK predicts poor prognosis of gastric adenocarcinoma","volume":"20","author":"Piao J","year":"2014","journal-title":"Diagn 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c\u00e2ncer retal antes da quimiorradioterapia"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032022000300414&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T19:47:26Z","timestamp":1662752846000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032022000300414&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["S0004-28032022000300414"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.202203000-74","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"type":"electronic","value":"1678-4219"},{"type":"print","value":"0004-2803"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}