{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:30:43Z","timestamp":1787502643888,"version":"build-2736575974"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Background: Pancreaticoduodenectomy is the procedure of choice for the treatment of resectable pancreaticoduodenal tumours. It has been proposed that jaundice is associated with worse outcomes, but the usefulness of preoperative biliary drainage in these patients is still controversial.  Methods: Retrospective cohort study of patients undergoing Whipple procedure at the Hospital Universitario San Ignacio, Bogot\u00e1 (Colombia), between January 2010 and June 2023. The cohort of patients who underwent preoperative biliary drainage was compared with those who went directly operated on. Comorbidities, functional status and procedural characteristics were recorded. The outcomes, including mortality and intraoperative and 30-day postoperative complications, were compared between groups.  Results: A total of 98 patients were included, 49 of whom underwent preoperative biliary drainage. In this group, there was a higher proportion of patients with pathological stage II and III disease (77.5 vs 49.0, P=0.04) and higher preoperative bilirubin levels (median 6.4 vs 4.9 mg\/dL; P=0.02). There were no differences in intraoperative (10.2% vs 14.3%; P=0.34) or postoperative (61.2% vs 51%; P=0.15) complications, but 30-day mortality was higher in patients with biliary drainage (8.2 vs 20.4%; P=0.03).  Conclusion: Our data suggest that there are no differences in postoperative complications. The higher mortality rate in patients with preoperative biliary drainage may be related to differences in baseline patient characteristics and\/or delays between biliary drainage and Whipple procedure.<\/jats:p>","DOI":"10.1590\/s0004-2803.24612024-089","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T15:05:00Z","timestamp":1753110300000},"source":"Crossref","is-referenced-by-count":1,"title":["OUTCOMES OF PATIENTS UNDERGOING PANCREATODUODENECTOMY (WHIPPLE\u2019S PROCEDURE) ACCORDING TO THE PRESENCE OF PREOPERATIVE BILIARY DRAINAGE"],"prefix":"10.1590","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5660-6229","authenticated-orcid":false,"given":"R\u00f3mulo","family":"VARGAS-RUBIO","sequence":"first","affiliation":[{"name":"Hospital Universitario San Ignacio,  Colombia; Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-7947","authenticated-orcid":false,"given":"Ana Maria","family":"LEGUIZAMO-NARANJO","sequence":"additional","affiliation":[{"name":"Hospital Universitario San Ignacio,  Colombia; Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5401-0018","authenticated-orcid":false,"given":"Oscar","family":"MU\u00d1OZ-VELANDIA","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia; Hospital Universitario San Ignacio,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7590-458X","authenticated-orcid":false,"given":"Cristiam David","family":"PULGARIN-HERRERA","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6392-7554","authenticated-orcid":false,"given":"Carlos Ernesto","family":"LOMBO","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-3864","authenticated-orcid":false,"given":"Liliana","family":"CUEVAS-LOPEZ","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-8493","authenticated-orcid":false,"given":"Elio Fabio","family":"SANCHEZ","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-4502","authenticated-orcid":false,"given":"Francisco Javier","family":"HENAO","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana,  Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/00000658-198910000-00015","article-title":"Experience with 647 consecutive tumors of the duodenum, ampulla, head of the pancreas, and distal common bile duct","volume":"210","author":"Michelassi F","year":"1989","journal-title":"Ann Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4240\/wjgs.v11.i6.296","article-title":"Role of total pancreatectomy in the treatment of paraduodenal pancreatitis: A case report","volume":"11","author":"Mikuli\u0107 D","year":"2019","journal-title":"World J Gastrointest Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1007\/s00534-009-0142-2","article-title":"Laparoscopic Whipple 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G","year":"2010","journal-title":"Pancreas"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.surg.2016.11.001","article-title":"Preoperative biliary stenting versus operation first in jaundiced patients due to malignant lesions in the pancreatic head: A meta-analysis of current literature","volume":"161","author":"Scheufele F","year":"2017","journal-title":"Surgery"},{"key":"ref39","first-page":"3215","article-title":"Duration of Preoperative Biliary Drainage as a Prognostic Factor After Pancreaticoduodenectomy for Pancreatic Head Cancer","volume":"37","author":"Matsumoto M","year":"2017","journal-title":"Anticancer Res"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["Resultados de pacientes submetidos \u00e0 duodenopancreatectomia (procedimento de Whipple) de acordo com a presen\u00e7a de drenagem biliar pr\u00e9-operat\u00f3ria"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032025000100901&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T15:05:05Z","timestamp":1753110305000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032025000100901&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":39,"alternative-id":["S0004-28032025000100901"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.24612024-089","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"value":"1678-4219","type":"electronic"},{"value":"0004-2803","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e24089"}}