{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:15:52Z","timestamp":1761578152966,"version":"build-2065373602"},"reference-count":14,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"abstract":"<jats:p>ABSTRACT  Introduction: Helicobacter pylori infection has a high prevalence in Brazil, and eradication therapy is recommended for all diagnosed cases. While smoking has been identified as a factor associated with therapeutic failure, its impact on treatment efficacy has not yet been conclusively demonstrated in studies conducted within the Brazilian population.  Objective: To determine the factors associated with Helicobacter pylori eradication failure in patients submitted to empirical 14-day antimicrobial therapy with omeprazole 20 mg BID, amoxicillin 1 g BID, and clarithromycin 500 mg BID at a Brazilian university center.  Methods: An observational and retrospective study was conducted in the Hospital de Clinicas, University of Campinas, Brazil, between April 2022 and September 2023. The study included treatment-naive patients with Helicobacter pylori infection. These patients received PPI-clarithromycin triple therapy and underwent the 13C-urea breath test (13C-UBT) to evaluate eradication. Clinical and demographic variables were analyzed as potential factors associated with therapeutic failure, including age, gender, obesity, diabetes mellitus, anxiety and depression disorders, irritable bowel syndrome, fibromyalgia, smoking, alcoholism and cirrhosis.  Results:  A total of 97 patients were included, with a mean age of 55\u00b114 years, 67 (69.1%) female. The antimicrobial treatment achieved 90.7% effectiveness (n=88). Smoking (P=0.0068) was the only factor associated with eradication failure after multiple regression analysis.  Conclusion: Smoking was the only factor associated with Helicobacter pylori eradication failure, as determined by the 13C-urea breath test.<\/jats:p>","DOI":"10.1590\/s0004-2803.24612025-059","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:03:00Z","timestamp":1761577380000},"source":"Crossref","is-referenced-by-count":0,"title":["SMOKING IMPACTS HELICOBACTER PYLORI ERADICATION: RESULTS FROM A BRAZILIAN UNIVERSITY HOSPITAL"],"prefix":"10.1590","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5451-7051","authenticated-orcid":false,"given":"Amanda Avesani Cavotto Furlan Relva da","family":"FONTE","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4424-6606","authenticated-orcid":false,"given":"Marlone","family":"CUNHA-SILVA","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6833-8759","authenticated-orcid":false,"given":"Michelle Viviane S\u00e1 dos Santos","family":"RONDON","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-2878","authenticated-orcid":false,"given":"Cristina Rodrigues dos","family":"SANTOS","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8109-7195","authenticated-orcid":false,"given":"Natalicia Hifumi","family":"HARA","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-1677","authenticated-orcid":false,"given":"Cristiane Kibune","family":"NAGASAKO","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1590\/0102-6720201600030006","article-title":"Prevalence of Helicobacter pylori ten years ago compared to the current prevalence in patients undergoing upper endoscopy","volume":"29","author":"Frugis S","year":"2016","journal-title":"ABCD Arq Bras Cir Dig"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"11950","DOI":"10.3748\/wjg.v20.i34.11950","article-title":"Extraintestinal manifestations of Helicobacter pylori: A concise review","volume":"20","author":"Wong F","year":"2014","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00004836-200210000-00007","article-title":"Factors associated with treatment failure of Helicobacter pylori infection in a developing country","volume":"35","author":"Queiroz DM","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1590\/s0004-2803.201800000-20","article-title":"IVth Brazilian Consensus Conference on Helicobacter pylori infection","volume":"55","author":"Coelho LGV","year":"2018","journal-title":"Arq Gastroenterol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2631774519843401","DOI":"10.1177\/2631774519843401","article-title":"The validity of breath collection bags using the novel BreathID\u00ae Hp Lab System: a multicenter clinical study in 257 subjects","volume":"12","author":"Shirin H","year":"2019","journal-title":"Ther Adv Gastrointest Endosc"},{"key":"ref6","first-page":"Doc14","article-title":"Efficacy and cost-effectiveness of the 13C-urea breath test as the primary diagnostic investigation for the detection of Helicobacter pylori infection compared to invasive and non-invasive diagnostic tests","volume":"5","author":"Nocon M","year":"2009","journal-title":"GMS Health Technol Assess"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1523-5378.2011.00863.x","article-title":"13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis","volume":"16","author":"Leal YA","year":"2011","journal-title":"Helicobacter"},{"key":"ref8","first-page":"13841","article-title":"Diagnosis of Helicobacter pylori infection in patients with atrophic gastritis: comparison of histology, 23.C-urea breath test, and serology","volume":"35","author":"Kokkola A","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"100117","DOI":"10.1111\/j.1365-2036.2004.02203.x","article-title":"Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection a critical review","volume":"20","author":"Gisbert JP","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1053\/j.gastro.2020.11.059","article-title":"AGA Clinical practice update on the management of refractory Helicobacter pylori Infection: expert review","volume":"160","author":"Shah SC","year":"2021","journal-title":"Gastroenterology"},{"key":"ref11","first-page":"238","article-title":"Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia","volume":"37","author":"Camargo MC","year":"2007","journal-title":"Acta Gastroenterol Latinoam"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.2478\/v10039-008-0043-7","article-title":"Smoking and drinking habits are important predictors of Helicobacter pylori eradication","volume":"53","author":"Namiot DB","year":"2008","journal-title":"Adv Med Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000490889","article-title":"Smoking and Drinking Did Not Increase the Failure of Therapeutic Helicobacter pylori Eradication by Vonoprazan, Clarithromycin, and Amoxicillin","volume":"99","author":"Akara Y","year":"2019","journal-title":"Digestion"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.dld.2017.03.010","article-title":"Smoking increases the likelihood of Helicobacter pylori treatment failure","volume":"49","author":"Itskoviz D","year":"2017","journal-title":"Dig Liver Dis"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":["Tabagismo impacta erradica\u00e7\u00e3o de Helicobacter pylori: resultados de um hospital universit\u00e1rio no Brasil"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0004-28032025000100210&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:03:02Z","timestamp":1761577382000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032025000100210&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":14,"alternative-id":["S0004-28032025000100210"],"URL":"https:\/\/doi.org\/10.1590\/s0004-2803.24612025-059","relation":{},"ISSN":["1678-4219","0004-2803"],"issn-type":[{"type":"electronic","value":"1678-4219"},{"type":"print","value":"0004-2803"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e25059"}}