{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T07:08:03Z","timestamp":1648624083978},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>A isoniazida e a pirazinamida s\u00e3o drogas hepatot\u00f3xicas bem conhecidas. O aparecimento da les\u00e3o hep\u00e1tica, em rela\u00e7\u00e3o ao in\u00edcio do tratamento, \u00e9 precoce com a isoniazida e mais tardio e mais grave com a pirazinamida. O objetivo deste trabalho \u00e9 relatar caso de um lactente de cinco meses de idade com tuberculose pulmonar e men\u00edngea, que desenvolveu hepatite t\u00f3xica com insufici\u00eancia hep\u00e1tica, durante o uso de isoniazida, pirazinamida e rifampicina. As manifesta\u00e7\u00f5es cl\u00ednicas e as altera\u00e7\u00f5es laboratoriais foram detectadas no quinto dia de tratamento e a melhora foi r\u00e1pida, estando praticamente recuperado no final da primeira semana, ap\u00f3s suspens\u00e3o da isoniazida. Embora tenha tido necessidade de suporte em unidade de terapia intensiva, teve evolu\u00e7\u00e3o favor\u00e1vel, sem seq\u00fcelas.<\/jats:p>","DOI":"10.1590\/s0004-28032000000100014","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:18:33Z","timestamp":1113574713000},"page":"72-75","source":"Crossref","is-referenced-by-count":4,"title":["Insufici\u00eancia hep\u00e1tica pelo uso de isoniazida: relato de caso"],"prefix":"10.1590","volume":"37","author":[{"given":"Ricardo Mendes","family":"PEREIRA","sequence":"first","affiliation":[{"name":"Universidade de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia Teresinha","family":"TRESOLDI","sequence":"additional","affiliation":[{"name":"Universidade de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"HESSEL","sequence":"additional","affiliation":[{"name":"Universidade de 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