{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T05:30:36Z","timestamp":1649050236227},"reference-count":43,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>A doen\u00e7a hep\u00e1tica, alcoolismo e desnutri\u00e7\u00e3o s\u00e3o condi\u00e7\u00f5es comumente associadas que interferem no metabolismo de micronutrientes. Como resultado da doen\u00e7a hep\u00e1tica pode ocorrer menor estocagem e convers\u00e3o de vitaminas nas suas formas ativas, e m\u00e1 digest\u00e3o e\/ou m\u00e1 absor\u00e7\u00e3o. H\u00e1 ainda o agravante do \u00e1lcool diminuindo a ingest\u00e3o e absor\u00e7\u00e3o de micronutrientes em virtude da redu\u00e7\u00e3o da ingest\u00e3o diet\u00e9tica e de sua associa\u00e7\u00e3o com doen\u00e7a do intestino delgado ou pancre\u00e1tica. Outras causas de defici\u00eancias seriam: tratamento com drogas, peroxida\u00e7\u00e3o lip\u00eddica, d\u00e9ficit prot\u00e9ico, maior excre\u00e7\u00e3o urin\u00e1ria e aumento da necessidade e degrada\u00e7\u00e3o de nutrientes. Como conseq\u00fc\u00eancias dessas defici\u00eancias, esses pacientes apresentam usualmente anemia, esteatose hep\u00e1tica, estresse oxidativo e imunossupress\u00e3o.<\/jats:p>","DOI":"10.1590\/s0004-28032000000200009","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:18:39Z","timestamp":1113574719000},"page":"120-124","source":"Crossref","is-referenced-by-count":7,"title":["Implica\u00e7\u00f5es do alcoolismo e da doen\u00e7a hep\u00e1tica cr\u00f4nica sobre o metabolismo de micronutrientes"],"prefix":"10.1590","volume":"37","author":[{"given":"Regiane","family":"MAIO","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane Bandeira","family":"DICHI","sequence":"additional","affiliation":[{"name":"UNESP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Carlos","family":"BURINI","sequence":"additional","affiliation":[{"name":"UNESP; Universidade Estadual Paulista"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","article-title":"Altera\u00e7\u00f5es imunit\u00e1rias na cirrose hep\u00e1tica alco\u00f3lica","volume":"32","author":"Calamita Z","year":"1995","journal-title":"Arq Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0004-2803","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1016\/0026-0495(95)90190-6","article-title":"Short-term changes in energy metabolism after 1 month of a regular oral diet in severely malnourished cirrhotic patients","volume":"44","author":"Campillo B","year":"1995","journal-title":"Metabolism","ISSN":"http:\/\/id.crossref.org\/issn\/0026-0495","issn-type":"print"},{"key":"ref3","series-title":"The vitamins: fundamental aspects in nutrition and health","first-page":"295, 366, 399, 404","author":"Combs GF Jr.","year":"1992"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/63.2.220","article-title":"Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status","volume":"63","author":"Cravo ML","year":"1996","journal-title":"Am J Clin Nutr","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9165","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1016\/0016-5085(90)90458-D","article-title":"Natural history of congestive gastropathy in cirrhosis: The Liver Study Group of V. 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