{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:32:39Z","timestamp":1758479559045},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>The authors describe the case of a young Brazilian woman who was treated of ileocolonic Crohn's disease sparing rectum, as confirmed by colonoscopy and histopathological examination. After a 4-year course of sulfasalazine treatment, she presented with skin facial lesions in vespertilio, fever, arthralgias and high titers of anti-ANA and LE cells. A sulfasalazine-induced lupus syndrome was diagnosed, because after sulfasalazine withdrawal and a short course of prednisone, the clinical symptoms disappeared and the laboratory tests returned to normal. Mesalazine 3 g\/day was started and the patient remained well for the next 3 years, when she was again admitted with fever, weakness, arthralgias, diplopy, strabismus and hypoaesthesia in both hands and feet, microhematuria, haematic casts, hypocomplementemia and high titers of autoimmune antibodies. A diagnosis of associated systemic lupus erythematosus was made. Although a pulsotherapy with methylprednisolone was started, no improvement was noticed. A cyclophosphamide trial was tried and again no positive results occurred. The patient evolved to severe clinical manifestations of general vasculitis affecting the central and peripheral nervous system and lungs, having a fatal evolution after 2 weeks. Although uncommon, the association of both disease may occur, and the authors call attention to this possibility, making a brief review of literature.<\/jats:p>","DOI":"10.1590\/s0004-28032000000400007","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:18:50Z","timestamp":1113574730000},"page":"224-226","source":"Crossref","is-referenced-by-count":6,"title":["Fatal evolution of systemic lupus erythematosus associated with Crohn's disease"],"prefix":"10.1590","volume":"37","author":[{"given":"J\u00falio M. Fonseca","family":"CHEBLI","sequence":"first","affiliation":[{"name":"Juiz de Fora University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Duarte","family":"GABURRI","sequence":"additional","affiliation":[{"name":"Juiz de Fora University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00e9cio Fl\u00e1vio Meirelles de","family":"SOUZA","sequence":"additional","affiliation":[{"name":"Juiz de Fora University,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia Val\u00e9ria Bastos","family":"DIAS","sequence":"additional","affiliation":[{"name":"Juiz de Fora University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Oliveira","family":"CIMINO","sequence":"additional","affiliation":[{"name":"Juiz de Fora University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Jos\u00e9 de","family":"CARVALHO-FILHO","sequence":"additional","affiliation":[{"name":"Juiz de Fora University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando de Azevedo","family":"LUCCA","sequence":"additional","affiliation":[{"name":"Juiz de Fora University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1097\/00007611-199510000-00018","article-title":"Crohn's disease masquerading as systemic lupus erythemathosus","volume":"88","author":"Buchman AL","year":"1995","journal-title":"South Med J","ISSN":"http:\/\/id.crossref.org\/issn\/0038-4348","issn-type":"print"},{"key":"ref2","article-title":"Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease","volume":"77","author":"Carr-Locke DL","year":"1982","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref3","article-title":"Crohn disease and systemic 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Rheum","ISSN":"http:\/\/id.crossref.org\/issn\/0049-0172","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1016\/S0016-5085(88)80094-5","article-title":"Remission of Crohn's disease after human immunodeficiency virus infection","volume":"95","author":"James SP","year":"1988","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref7","article-title":"Crohn's disease and systemic lupus erythematosus","volume":"11","author":"Johnson DA","year":"1985","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1111\/j.1572-0241.1998.00734.x","article-title":"Familial Crohn's disease with systemic lupus erythematosus","volume":"93","author":"Nishida Y","year":"1998","journal-title":"Am J 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