{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T18:47:35Z","timestamp":1649098055937},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Racional - Um dos problemas na avalia\u00e7\u00e3o de pacientes disp\u00e9pticos em institui\u00e7\u00f5es p\u00fablicas \u00e9 o intervalo de tempo prolongado entre a consulta inicial e a endoscopia digestiva alta, levando \u00e0 introdu\u00e7\u00e3o de terap\u00eautica anti-secretora nesse per\u00edodo. Desta forma, os resultados do exame podem n\u00e3o traduzir a condi\u00e7\u00e3o inicialmente suspeitada. Objetivos - Analisar as altera\u00e7\u00f5es no teste ultra-r\u00e1pido da urease e no exame anatomopatol\u00f3gico para Helicobacter pylori ap\u00f3s o uso de drogas anti-secretoras. Casu\u00edstica e M\u00e9todo - Foram avaliados, de forma prospectiva e duplo-cega, 50 pacientes com queixas disp\u00e9pticas e diagn\u00f3stico endosc\u00f3pico de \u00falcera p\u00e9ptica, gastrite, esofagite ou duodenite erosivas e com teste da urease positivo. Os pacientes foram divididos, de forma randomizada, em dois grupos: 25 usaram ranitidina 300 mg\/dia e 25, omeprazol 20 mg\/dia, durante 7 dias. Antes e ap\u00f3s o tratamento, dois fragmentos de biopsia foram obtidos do antro e corpo g\u00e1stricos, realizando-se o teste ultra-r\u00e1pido da urease e o exame anatomopatol\u00f3gico para Helicobacter pylori. Resultados - No grupo que usou ranitidina, n\u00e3o se observaram altera\u00e7\u00f5es significativas na positividade do teste ultra-r\u00e1pido da urease e do exame anatomopatol\u00f3gico no antro e corpo g\u00e1stricos, ap\u00f3s 7 dias de medica\u00e7\u00e3o. Nos pacientes que utilizaram omeprazol, ap\u00f3s tal per\u00edodo, observou-se redu\u00e7\u00e3o da positividade do teste ultra-r\u00e1pido da urease e do exame anatomopatol\u00f3gico no antro g\u00e1strico, sendo que o mesmo n\u00e3o ocorreu na regi\u00e3o do corpo. Conclus\u00e3o - O omeprazol, utilizado por um per\u00edodo de 7 dias, \u00e9 capaz de levar a uma negativa\u00e7\u00e3o do teste ultra-r\u00e1pido da urease e do exame anatomopatol\u00f3gico para Helicobacter pylori no antro g\u00e1strico, devendo ser desaconselhado para pacientes aguardando realiza\u00e7\u00e3o de endoscopia digestiva,<\/jats:p>","DOI":"10.1590\/s0004-28032001000100002","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:19:26Z","timestamp":1115929166000},"page":"03-08","source":"Crossref","is-referenced-by-count":0,"title":["Altera\u00e7\u00f5es no teste ultra-r\u00e1pido da urease e no exame anatomopatol\u00f3gico para Helicobacter pylori induzidas por drogas anti-secretoras"],"prefix":"10.1590","volume":"38","author":[{"given":"Lincoln Eduardo Villela Vieira de Castro","family":"FERREIRA","sequence":"first","affiliation":[{"name":"Universidade Federal de Juiz de Fora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo de Souza Portes","family":"MEIRELLES","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata La Rocca","family":"VIEIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Augusto","family":"BRAGAGNOLO Jr.","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio Maria Fonseca","family":"CHEBLI","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A\u00e9cio Fl\u00e1vio Meirelles de","family":"SOUZA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora; Universidade Federal de Juiz de Fora; Universidade Federal de Juiz de Fora"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"8587","key":"ref1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0140-6736(88)91501-2","article-title":"One minute endoscopy room test for Campylobacter pylori [letter]","volume":"1","author":"Arvind AS","year":"1988","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1136\/gut.36.5.670","article-title":"Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine","volume":"36","author":"Atherton JC","year":"1955","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/0016-5085(92)91716-H","article-title":"Difference in expression of Helicobacter pylori gastritis in antrum and body","volume":"102","author":"Bayerd\u00f6rffer E","year":"1992","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1053\/gast.1996.v110.pm8613015","article-title":"Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence: a review","volume":"110","author":"Hopkins RJ","year":"1996","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref5","first-page":"481","article-title":"pH and H. pylori - gastric acid secretion and Helicobacter pylori: implications for ulcer healing and eradication of the organism","volume":"88","author":"Hunt RH.","year":"1993","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/AAC.35.3.490","article-title":"Lansoprazole, a novel benzimidazole proton pump inhibitor and its related compounds have selective activity against Helicobacter pylori","volume":"35","author":"Iwahi T","year":"1991","journal-title":"Antimicrobial Agents Chemother"},{"key":"ref7","series-title":"Helicobacter pylori - Techniques for clinical diagnosis & basic research","first-page":"1","volume-title":"Upper digestive tract endoscopy and rapid diagnosis of Helicobacter pylori infection","author":"Lamouliatte H","year":"1996"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/gut.36.1.12","article-title":"Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole","volume":"36","author":"Logan RPH","year":"1995","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref9","first-page":"1011","article-title":"Are clinical patterns of dyspepsia a valid guideline for appropriate use of endoscopy? 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