{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:59:50Z","timestamp":1700668790919},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:p>Racional - O megac\u00f3lon t\u00f3xico \u00e9 complica\u00e7\u00e3o grave e pouco freq\u00fcente na retocolite ulcerativa idiop\u00e1tica. Ocorre, geralmente, em pacientes cuja doen\u00e7a ativa \u00e9 resistente ao tratamento cl\u00ednico e, em algumas situa\u00e7\u00f5es, o fator desencadeante \u00e9 desconhecido. A infec\u00e7\u00e3o pelo cytomelogalovirus em seres humanos em geral \u00e9 evento subcl\u00ednico; entretanto, em pacientes imunocomprometidos a primoinfec\u00e7\u00e3o ou mesmo a reativa\u00e7\u00e3o de infec\u00e7\u00e3o latente pode ter amplas repercuss\u00f5es cl\u00ednicas, uma das quais o desencadeamento de megac\u00f3lon t\u00f3xico. Objetivo - Descrever um caso de megac\u00f3lon t\u00f3xico fatal por cytomegalovirose em paciente com retocolite ulcerativa idiop\u00e1tica. Paciente - Masculino, 38 anos, com cl\u00ednica de diarr\u00e9ia e perda ponderal cuja investiga\u00e7\u00e3o mostrou tratar-se de retocolite ulcerativa idiop\u00e1tica e para a qual foi institu\u00edda terap\u00eautica imunossupressora vigorosa. Resultados - Evoluiu com quadro cl\u00ednico de megac\u00f3lon t\u00f3xico, sendo submetido a colectomia total. Complica\u00e7\u00f5es cl\u00ednicas culminaram no \u00f3bito p\u00f3s-operat\u00f3rio e o estudo anatomopatol\u00f3gico do c\u00f3lon revelou doen\u00e7a ativa, associada a ulcera\u00e7\u00f5es confluentes na base das quais foram observadas c\u00e9lulas com altera\u00e7\u00f5es caracter\u00edsticas da cytomegalovirose. Conclus\u00e3o - A cytomegalovirose deve ser considerada como um dos agentes causadores de megac\u00f3lon t\u00f3xico em retocolite ulcerativa.<\/jats:p>","DOI":"10.1590\/s0004-28032002000200008","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:19:44Z","timestamp":1113574784000},"page":"111-113","source":"Crossref","is-referenced-by-count":3,"title":["Megac\u00f3lon t\u00f3xico fatal por cytomegalovirus em paciente com retocolite ulcerativa idiop\u00e1tica: relato de caso e revis\u00e3o de literatura"],"prefix":"10.1590","volume":"39","author":[{"given":"S\u00e9rgio Ossamu","family":"IOSHII","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane","family":"TEIXEIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Maria S.","family":"FIGUEIREDO","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"355","article-title":"Cytomegalovirus infection of the colon: A possible role in exacerbations of inflammatory bowel disease","volume":"80","author":"Berk T","year":"1985","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0016-5085(77)80021-8","article-title":"Cytomegalovirus inclusions in patients with ulcerative colitis and toxic dilatation requiring colinic resection","volume":"72","author":"Cooper HS","year":"1977","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/ajcp\/76.6.788","article-title":"Colon ulceration in lethal cytomegalovirus infection","volume":"76","author":"Foucar E","year":"1981","journal-title":"Am J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"key":"ref4","first-page":"201","article-title":"Intestinal perforation associated with cytomegalovirus infection in patients with acquired immune deficiency syndrome","volume":"79","author":"Frank D","year":"1984","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"924","DOI":"10.7326\/0003-4819-119-9-199311010-00010","article-title":"Gastrointestinal cytomegalovirus disease","volume":"119","author":"Goodgame RW","year":"1993","journal-title":"Ann Intern Med","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF01297124","article-title":"Perforation of the colon associated with cytomegalovirus infection","volume":"24","author":"Goodman ZD","year":"1979","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref7","first-page":"477","article-title":"Cytomegalovirus inclusion bodies in the gastrointestinal tract","volume":"93","author":"Henson D","year":"1972","journal-title":"Arch Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0363-0153","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.7326\/0003-4819-108-4-585","article-title":"Clinical findings, diagnosis and treatment","volume":"108","author":"Jacobson MA","year":"1988","journal-title":"Ann Intern Med","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0030-4220(87)90088-0","article-title":"Oral mucosal cytomegalovirus as a manifestation of the acquired immune deficiency syndrome","volume":"64","author":"Kanas RJ","year":"1987","journal-title":"Oral Surg Oral Med Pathol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/BF02139220","article-title":"Intestinal perforation due to cytomegalovirus infection in patients with AIDS","volume":"33","author":"Kram HB","journal-title":"Dis Colon Rectum1990"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1288\/00005537-198504000-00006","article-title":"Otolaryngologic and head and neck manifestations of acquired immunodeficiency syndrome (AIDS)","volume":"95","author":"Marcusen DC","year":"1985","journal-title":"Laringoscope"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0016-5085(85)80150-5","article-title":"Cytomegalovirus colitis: report of the clinical, endoscopic, and pathologic findings in two patients with the acquired immune deficiency syndrome","volume":"88","author":"Meilseman MS","year":"1985","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/BF01540440","article-title":"Cytomegalovirus colitis in patients with acquired immunodeficiency syndrome","volume":"33","author":"Rene E","year":"1988","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1093\/ajcp\/89.5.666","article-title":"Comparison of immunoperoxidase and DNA in situ hybridazation techniques in the diagnosis of cytomegalovirus colitis","volume":"89","author":"Robey SS","year":"1988","journal-title":"Am J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1001\/archsurg.1979.01370310099019","article-title":"Cytomegalovirus infection of the colon associated with ulcerative colitis","volume":"114","author":"Sidi S","year":"1979","journal-title":"Arch Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v39n2\/a08v39n2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T22:18:05Z","timestamp":1586211485000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032002000200008&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,4]]}},"alternative-id":["S0004-28032002000200008"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032002000200008","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}