{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T18:03:54Z","timestamp":1708970634826},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>RACIONAL: O transplante de f\u00edgado \u00e9 aceito como modalidade terap\u00eautica efetiva nas doen\u00e7as hep\u00e1ticas avan\u00e7adas, incluindo a cirrose alco\u00f3lica. OBJETIVO: Avaliar os resultados do transplante hep\u00e1tico em pacientes com cirrose alco\u00f3lica no Programa de Transplante Hep\u00e1tico do Hospital de Cl\u00ednicas da Universidade Federal do Paran\u00e1, Curitiba, PR. PACIENTES E M\u00c9TODOS: An\u00e1lise retrospectiva dos pacientes com cirrose alco\u00f3lica submetidos a transplante hep\u00e1tico no Servi\u00e7o de Transplante Hep\u00e1tico do Hospital de Cl\u00ednicas da Universidade Federal do Paran\u00e1 entre setembro de 1991 e janeiro de 2001. Todos os candidatos apresentavam per\u00edodo de abstin\u00eancia de \u00e1lcool &gt; 6 meses antes do transplante. A identifica\u00e7\u00e3o do consumo de \u00e1lcool no per\u00edodo p\u00f3s-transplante hep\u00e1tico baseou-se em: (1) informa\u00e7\u00f5es fornecidas pelo paciente e\/ou familiares, e\/ou (2) anormalidades bioqu\u00edmicas sugestivas de consumo abusivo de \u00e1lcool associadas a anormalidades histol\u00f3gicas compat\u00edveis com les\u00e3o pelo etanol. RESULTADOS: Vinte adultos com cirrose alco\u00f3lica (19 homens e 1 mulher) com mediana de idade de 50 anos (29-61 anos) foram submetidos a transplante hep\u00e1tico, correspondendo a 13,8% das indica\u00e7\u00f5es de transplante hep\u00e1tico em adultos. Em 30% dos pacientes (6\/20) houve associa\u00e7\u00e3o com hepatite viral cr\u00f4nica, e em 1 caso (5%) presen\u00e7a de hepatocarcinoma. A maioria dos pacientes apresentava disfun\u00e7\u00e3o hep\u00e1tica grave no pr\u00e9-transplante (75% Child C). A mediana do tempo de abstin\u00eancia pr\u00e9-transplante foi de 24 meses (9 a 120 meses). A mediana do tempo de seguimento p\u00f3s-transplante foi de 14 meses (1 a 66 meses). A sobrevida do paciente em 1 e 3 anos ap\u00f3s o transplante hep\u00e1tico foi de 75% e 50%, respectivamente. As principais complica\u00e7\u00f5es observadas foram: rejei\u00e7\u00e3o aguda (n = 8; 40%), rejei\u00e7\u00e3o cr\u00f4nica (n = 1; 5%), trombose da art\u00e9ria hep\u00e1tica (n = 3; 15%), complica\u00e7\u00f5es biliares (n = 3; 15%) infec\u00e7\u00e3o por citomegalov\u00edrus (n = 4; 20%), infec\u00e7\u00f5es bacterianas e f\u00fangicas (n = 9; 45%). A incid\u00eancia detectada de recidiva do consumo de \u00e1lcool foi de 15% (3\/20). Em um dos casos de recidiva o uso inadequado dos imunossupressores resultou em rejei\u00e7\u00e3o cr\u00f4nica com perda do enxerto. CONCLUS\u00d5ES: Transplante hep\u00e1tico na cirrose alco\u00f3lica associou-se a n\u00edveis satisfat\u00f3rios de sobrevida a curto e m\u00e9dio prazo. No presente estudo a recidiva do consumo de \u00e1lcool foi pequena, o que pode ser devido \u00e0 falta de rastreamento adequado.<\/jats:p>","DOI":"10.1590\/s0004-28032002000300003","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T10:19:54Z","timestamp":1113560394000},"page":"147-152","source":"Crossref","is-referenced-by-count":5,"title":["Resultados do transplante de f\u00edgado na doen\u00e7a hep\u00e1tica alco\u00f3lica"],"prefix":"10.1590","volume":"39","author":[{"given":"M\u00f4nica Beatriz","family":"Parolin","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio Cezar Uili","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro da","family":"Igreja","sequence":"additional","affiliation":[{"name":"Universidade Federal do 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