{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:47:31Z","timestamp":1761126451545},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>RACIONAL: A esofagite induzida por drogas pode ser decorrente do contato prolongado do medicamento com a mucosa ou de altera\u00e7\u00f5es das condi\u00e7\u00f5es locais da mucosa esof\u00e1gica. O uso de alendronato de s\u00f3dio, um inibidor da reabsor\u00e7\u00e3o \u00f3ssea utilizado na preven\u00e7\u00e3o e tratamento da osteoporose, tem sido recentemente citado como causa de les\u00f5es no trato gastrointestinal superior. OBJETIVO: Descrever os achados cl\u00ednicos, endosc\u00f3picos e histopatol\u00f3gicos de pacientes com esofagite ulcerativa associada ao uso de alendronato de s\u00f3dio. PACIENTES: Quatro pacientes do sexo feminino e um do sexo masculino, em tratamento de osteoporose com alendronato de s\u00f3dio, submetidos a endoscopia digestiva alta seguida de biopsia esof\u00e1gica. RESULTADOS: Os pacientes apresentavam idade entre 64 e 84 anos e sintomatologia disp\u00e9ptica ap\u00f3s um per\u00edodo de 2 a 12 meses de uso de alendronato de s\u00f3dio. A endoscopia digestiva mostrou \u00e1rea de mucosa fri\u00e1vel, com eros\u00e3o e\/ou ulcera\u00e7\u00e3o recobertas por fibrina, localizadas no ter\u00e7o distal do es\u00f4fago. O exame histopatol\u00f3gico mostrou esofagite ulcerativa caracterizada por material necrofibrinopurulento e tecido de granula\u00e7\u00e3o, al\u00e9m de material amarelado e refringente \u00e0 luz polarizada. Os pacientes evolu\u00edram com remiss\u00e3o completa dos sintomas ap\u00f3s suspens\u00e3o da droga. CONCLUS\u00d5ES: As les\u00f5es esof\u00e1gicas associadas ao uso de alendronato de s\u00f3dio n\u00e3o s\u00e3o freq\u00fcentes e parecem estar relacionadas ao uso incorreto da medica\u00e7\u00e3o. Os endoscopistas e patologistas devem ficar atentos \u00e0 possibilidade do uso de alendronato de s\u00f3dio diante do diagn\u00f3stico de \u00falceras esof\u00e1gicas em pacientes idosos, principalmente do sexo feminino. Esta identifica\u00e7\u00e3o implicaria em melhor tratamento dos pacientes.<\/jats:p>","DOI":"10.1590\/s0004-28032002000300007","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:19:54Z","timestamp":1113574794000},"page":"173-176","source":"Crossref","is-referenced-by-count":6,"title":["Esofagite ulcerativa associada ao uso de alendronato de s\u00f3dio: achados histopatol\u00f3gicos e endosc\u00f3picos"],"prefix":"10.1590","volume":"39","author":[{"given":"Paula \u00c1vila","family":"Fernandes","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio N\u00facleo - Anatomia Patol\u00f3gica e Citopatologia; Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Soares","family":"Pires","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Dr. Marcelo Soares Pires"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostinho Pinto","family":"Gouv\u00eaa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio N\u00facleo - 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