{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T12:40:18Z","timestamp":1695386418709},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>RACIONAL: A ader\u00eancia do Helicobacter pylori \u00e0 mucosa g\u00e1strica humana \u00e9 pr\u00e9-requisito para sua coloniza\u00e7\u00e3o e o desenvolvimento da gastrite cr\u00f4nica. Os ant\u00edgenos de grupos sang\u00fc\u00edneos, presentes no muco g\u00e1strico, s\u00e3o descritos como prov\u00e1veis receptores da bact\u00e9ria neste epit\u00e9lio. A express\u00e3o alterada destes ant\u00edgenos est\u00e1 associada ao desenvolvimento do c\u00e2ncer g\u00e1strico. OBJETIVOS: Verificar a ocorr\u00eancia do Helicobacter pylori e a distribui\u00e7\u00e3o da express\u00e3o dos ant\u00edgenos ABH e Lewis correlacionada com as altera\u00e7\u00f5es histopatol\u00f3gicas de pacientes com gastrite cr\u00f4nica. PACIENTES E M\u00c9TODOS: Analisaram-se 63 amostras de sangue, saliva e biopsias g\u00e1stricas de pacientes com gastrite cr\u00f4nica atrav\u00e9s das t\u00e9cnicas dot-blot-ELISA, imunoperoxidase indireta e colora\u00e7\u00f5es do Gram modificado e hematoxilina-eosina. RESULTADOS: N\u00e3o foram encontradas associa\u00e7\u00f5es significativas entre a presen\u00e7a da bact\u00e9ria e os fen\u00f3tipos de grupos sang\u00fc\u00edneos ABH, Lewis e Secretor. Na maioria dos pacientes, a express\u00e3o dos ant\u00edgenos ABH e Lewis, estava restrita principalmente ao epit\u00e9lio foveolar da mucosa g\u00e1strica, concordando com a express\u00e3o ao n\u00edvel salivar. A express\u00e3o inapropriada desses ant\u00edgenos ocorria sempre na infec\u00e7\u00e3o pelo Helicobacter pylori e\/ou altera\u00e7\u00f5es pr\u00e9-neopl\u00e1sicas da mucosa g\u00e1strica. Em \u00e1reas com metaplasia intestinal foi observada a redu\u00e7\u00e3o da reatividade para os ant\u00edgenos H e Le b, e principalmente o aumento de Le\u00aa. CONCLUS\u00c3O: Altera\u00e7\u00f5es no padr\u00e3o de glicosila\u00e7\u00e3o destes ant\u00edgenos refletem diferentes est\u00e1gios de diferencia\u00e7\u00e3o celular e s\u00e3o marcadores potenciais na avalia\u00e7\u00e3o diagn\u00f3stica e progn\u00f3stica das patologias g\u00e1stricas.<\/jats:p>","DOI":"10.1590\/s0004-28032002000400004","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:19:59Z","timestamp":1113574799000},"page":"222-232","source":"Crossref","is-referenced-by-count":9,"title":["Express\u00e3o dos ant\u00edgenos ABH e Lewis na gastrite cr\u00f4nica e altera\u00e7\u00f5es pr\u00e9- neopl\u00e1sica da mucosa g\u00e1strica"],"prefix":"10.1590","volume":"39","author":[{"given":"D\u00e9lia Cristina Figueira","family":"Aguiar","sequence":"first","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Cristina Oliveira","family":"Corvelo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marialva","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermelinda Moutinho da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samiry","family":"Daibes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Bara\u00fana de","family":"Assump\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal do Par\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0016-5085(97)70129-X","article-title":"Isolation of a cell surface component of Helicobacter pylori that binds H type 2, Lewis\u00aa, and Lewis b antigens","volume":"112","author":"Alkout AM","year":"1997","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref2","series-title":"Programa BioEstat 2.0: Aplica\u00e7\u00f5es estat\u00edsticas nas \u00e1reas das ci\u00eancias biol\u00f3gicas e m\u00e9dicas","author":"Ayres M","year":"2000"},{"key":"ref3","series-title":"Avalia\u00e7\u00e3o dos m\u00e9todos de diagn\u00f3stico histol\u00f3gico e sorol\u00f3gico voltados \u00e0 infec\u00e7\u00e3o pela Helicobacter pylori em gastrites cr\u00f4nicas","author":"Azevedo RSN","year":"2001"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1126\/science.8018146","article-title":"Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens","volume":"262","author":"Bor\u00e9n T","year":"1993","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1053\/gast.1997.v113.pm9247464","article-title":"Aberrant expression of gland-type gastric mucin in surface epithelium of Helicobacter pylori-infected patients","volume":"113","author":"Byrd JC","year":"1997","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref6","first-page":"5","article-title":"Campylobacter pyloridis in the upper gastrointestinal tract: a Brazilian study","volume":"24","author":"Coelho LGV","year":"1987","journal-title":"Arq Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0004-2803","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/(SICI)1096-9896(199608)179:4<358::AID-PATH564>3.0.CO;2-T","article-title":"Cell surface carbohydrates as prognostic markers in human carcinomas","volume":"179","author":"Dabelsteen E","year":"1996","journal-title":"J Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"key":"ref8","first-page":"390","article-title":"Metabolic and immunologic consequences of ABH secretor and Lewis subtype status","volume":"6","author":"D'Adamo PJ","year":"2001","journal-title":"Altern Med Rev","ISSN":"http:\/\/id.crossref.org\/issn\/1089-5159","issn-type":"print"},{"key":"ref9","first-page":"394","article-title":"Monoclonal antibody localization of Lewis antigens in fixed tissues","volume":"50","author":"Ernst C","year":"1984","journal-title":"Lab Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0023-6837","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1423-0410.1995.tb02591.x","article-title":"Lewis histo-blood group system and associated secretory phenotypes","volume":"69","author":"Henry S","year":"1995","journal-title":"Vox Sang","ISSN":"http:\/\/id.crossref.org\/issn\/0042-9007","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/1097-0142(19860401)57:7<1370::AID-CNCR2820570721>3.0.CO;2-J","article-title":"Sulphomucin colonic type intestinal metaplasia and carcinoma of the stomach","volume":"57","author":"Huang CB","year":"1986","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.279.5349.373","article-title":"Helicobacter pylori adhesin fucosilated histo-blood group antigens revelead by retagging","volume":"279","author":"Ilver D","year":"1998","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0304-4157(94)90017-5","article-title":"Blood grups antigens on humam erythrocytes-distribution, structure and possible functions","volume":"1197","author":"King MJ","year":"1994","journal-title":"Biochim Biophys Acta","ISSN":"http:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/S0140-6736(84)91816-6","article-title":"Unidentified curved Bacilli in the stomach of patients with gastritis and peptic ulceration","volume":"1","author":"Marshall BJ","year":"1984","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref15","first-page":"S116","article-title":"Helicobacter pylori","volume":"89 Suppl 8","author":"Marshal BJ","year":"1994","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref16","first-page":"292","article-title":"Epidemiology of Helicobacter pylori infection: where are we in 1995","volume":"7","author":"Megraud F","year":"1995","journal-title":"Eur J Gastroenterol Hepatol","ISSN":"http:\/\/id.crossref.org\/issn\/0954-691X","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/ajcp\/98.1.67","article-title":"Expression of blood group-related antigens, ABH, Lewis\u00aa, Lewis b, Lewis x, Lewis y, CA19-9, and CSLEX1 in early cancer, intestinal metaplasia, and univolved mucosa of the stomach","volume":"98","author":"Murata K","year":"1992","journal-title":"Am J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"key":"ref18","series-title":"Detec\u00e7\u00e3o do Campylobacter pylori atrav\u00e9s do gastroteste: an\u00e1lise de 50 pacientes","author":"Neto AS","year":"1990"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/gut.41.1.37","article-title":"Blood groups Lewis sup b and ABH expression in gastric mucosa: lack of inter-relation with Helicobacter pylori colonisation and occurrence of gastric MALT lymphoma","volume":"41","author":"Oberhuber G","year":"1997","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref20","series-title":"Blutgruppen-Immunhistochemie","author":"Pedal I","year":"1987"},{"key":"ref21","first-page":"153","article-title":"Das Samenbl\u00e4schenepithel Lewis-positiver Individuen sezerniert Le\u00aa in sialyerter Form","volume":"47","author":"Pedal I","year":"1989","journal-title":"Beitr Gerichtl Med","ISSN":"http:\/\/id.crossref.org\/issn\/0067-5016","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0379-0738(89)90133-3","article-title":"ABO and Lewis typing of secretion stains on nitrocellulose membranes using a new dot-blot-ELISA technique","volume":"43","author":"Pflug W","year":"1989","journal-title":"Forensic Sci Int","ISSN":"http:\/\/id.crossref.org\/issn\/0379-0738","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0463.2000.d01-1.x","article-title":"Tissue distribution of histo-blood group antigens","volume":"108","author":"Ravn V","year":"2000","journal-title":"APMIS","ISSN":"http:\/\/id.crossref.org\/issn\/0903-4641","issn-type":"print"},{"key":"ref24","series-title":"Perfil imunohistoqu\u00edmico da mucosa g\u00e1strica no desenvolvimento do c\u00e2ncer g\u00e1strico","author":"Sagica FES","year":"2000"},{"key":"ref25","first-page":"745","article-title":"Expression of Lewis a, Lewis b, Lewis x, Lewis y, sialyl Lewis a, and sialyl Lewis x blood group antigens in human gastric carcinoma and in normal gastric tissue","volume":"49","author":"Sakamoto S","year":"1989","journal-title":"Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2036.1998.00005.x","article-title":"Pathogenesis of the transformation from gastritis to malignancy","volume":"12 Suppl 1","author":"Sipponen P","year":"1998","journal-title":"Aliment Pharmacol Ther","ISSN":"http:\/\/id.crossref.org\/issn\/0269-2813","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1136\/jcp.46.9.832","article-title":"Prevalence of lymphoid follicles and aggregates in Helicobacter pylori gastritis in antral and body mucosa","volume":"46","author":"Stolte M","year":"1993","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0016-5085(98)70082-4","article-title":"Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients","volume":"115","author":"Taylor DE","year":"1998","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0016-5085(92)90086-E","article-title":"Lewis antigen alterations in gastric cancer precursors","volume":"102","author":"Torrado J","year":"1992","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref30","first-page":"2135","article-title":"Helicobacter pylori infection and blood group antigens: lack of clinical association","volume":"91","author":"Umlauft F","year":"1996","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0889-8553(05)70139-4","article-title":"Gastric pathology associated with Helicobacter pylori","volume":"29","author":"Warren JR","year":"2000","journal-title":"Gastroenterol Clin North Am","ISSN":"http:\/\/id.crossref.org\/issn\/0889-8553","issn-type":"print"},{"key":"ref32","first-page":"101","article-title":"Helicobacter pylori and blood groups","volume":"91","author":"Yaron N","year":"1996","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0016-5085(93)90148-6","article-title":"Mechanisms involved in Helicobacter pylori-induced gastritis","volume":"105","author":"Yoshida N","year":"1993","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v39n4\/a04v39n4.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T23:10:35Z","timestamp":1495667435000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032002000400004&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0004-28032002000400004"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032002000400004","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}