{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T10:02:28Z","timestamp":1648980148606},"reference-count":71,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>RACIONAL: O c\u00e2ncer de est\u00f4mago \u00e9 o segundo tipo mais comum de neoplasia no mundo. A carcinog\u00eanese de est\u00f4mago \u00e9 processo de m\u00faltiplos passos, podendo manifestar-se em v\u00e1rias etapas como gastrite superficial, gastrite atr\u00f3fica cr\u00f4nica, metaplasia intestinal, displasia e, finalmente, como um carcinoma. Essas condi\u00e7\u00f5es costumam ser seq\u00fcenciais e ocorrer num per\u00edodo de muitos anos como resultado da exposi\u00e7\u00e3o a uma variedade de fatores end\u00f3genos e ex\u00f3genos, que causam altera\u00e7\u00f5es gen\u00e9ticas. Os recentes avan\u00e7os da gen\u00e9tica molecular t\u00eam mostrado que o ac\u00famulo dessas v\u00e1rias anormalidades, incluindo a ativa\u00e7\u00e3o de oncogenes e a inativa\u00e7\u00e3o de genes supressores de tumores, resultam no desenvolvimento do c\u00e2ncer. Altera\u00e7\u00f5es gen\u00e9ticas descritas em carcinomas g\u00e1stricos incluem amplifica\u00e7\u00f5es e muta\u00e7\u00f5es dos genes c-ERBB2, K-RAS, c-MET e TP53. O ganho de cromossomos tamb\u00e9m foi encontrado em v\u00e1rias combina\u00e7\u00f5es com perda de outros cromossomos e pode estar associado com a express\u00e3o elevada de oncogenes, que contribuem com a progress\u00e3o tumoral. CONCLUS\u00c3O: Essas mudan\u00e7as gen\u00e9ticas em carcinomas evidenciam o processo de m\u00faltiplas etapas da carcinog\u00eanese g\u00e1strica, por meio do ac\u00famulo de uma s\u00e9rie de altera\u00e7\u00f5es.<\/jats:p>","DOI":"10.1590\/s0004-28032002000400009","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:19:59Z","timestamp":1113574799000},"page":"253-259","source":"Crossref","is-referenced-by-count":8,"title":["Fatores gen\u00e9ticos e ambientais envolvidos na carciog\u00eanese g\u00e1strica"],"prefix":"10.1590","volume":"39","author":[{"given":"Ana Cristina Gobbo","family":"C\u00e9sar","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Elizabete","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eloiza 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Chem","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S0046-8177(99)90098-9","article-title":"Trisomy 3 in gastric lymphomas of extranodal marginal zone-B cell (mucosa-associated lymphoid tissue) origin demonstrated by FISH in intact paraffin tissue sections","volume":"30","author":"Blanco R","year":"1999","journal-title":"Human Pathol"},{"key":"ref5","first-page":"870","article-title":"Prognostic factors in gastric cancer","volume":"11","author":"Brien TP","year":"1998","journal-title":"Mod Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0893-3952","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/(SICI)1096-9896(199706)182:2<167::AID-PATH830>3.0.CO;2-5","article-title":"Microsatellite instability in intestinal- and diffuse-type gastric carcinoma","volume":"182","author":"Buonsanti G","year":"1997","journal-title":"J Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/BF02212681","article-title":"Effect of eradication of Helicobacter pylori infection on gastric epithelial cell proliferation","volume":"40","author":"Cahill RJ","year":"1995","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/gut.48.6.808","article-title":"Soluble E-cadherine is a valid prognostic marker in gastric carcinoma","volume":"48","author":"Chan AO","year":"2001","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref9","series-title":"Precancerous lesions for the gastrointestinal tract","volume-title":"Atrophic gastritis","author":"Cheli R","year":"1983"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1002\/1097-0142(19920915)70:4+<1727::AID-CNCR2820701613>3.0.CO;2-P","article-title":"Genetic alterations in the adenoma-carcinoma sequence","volume":"70","author":"Cho KR","year":"1992","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref11","series-title":"Pathologic basis of disease","author":"Cotran RS","year":"1999","edition":"6"},{"key":"ref12","series-title":"Gastroenterologia essencial","author":"Dani R","year":"1998"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1088>3.0.CO;2-B","article-title":"Association between CagA+ Helicobacter pylori infection and p53, bax and transforming growth factor-beta-RII gene mutations in gastric cancer patients","volume":"91","author":"Deguchi R","year":"2001","journal-title":"Int J Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"key":"ref14","series-title":"Cancer: Principles and practice of oncology","author":"De Vita VT Jr","year":"1997","edition":"5"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH631>3.0.CO;2-2","article-title":"Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways","volume":"191","author":"Endoh Y","year":"2000","journal-title":"J Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3417","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-4608(98)00149-6","article-title":"Pathological and karyotypic abnormalities in advanced gastric carcinomas","volume":"109","author":"Espinoza LA","year":"1999","journal-title":"Cancer Genet Cytogenet","ISSN":"http:\/\/id.crossref.org\/issn\/0165-4608","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","article-title":"A genetic model for colorectal tumorigenesis","volume":"61","author":"Fearon ER","year":"1990","journal-title":"Cell","ISSN":"http:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2036.1994.tb00274.x","article-title":"Effect of eradiction of Helicobacter pylori on gastric epithelial cell proliferation","volume":"8","author":"Fraser AG","year":"1994","journal-title":"Aliment Pharmacol Ther","ISSN":"http:\/\/id.crossref.org\/issn\/0269-2813","issn-type":"print"},{"key":"ref19","first-page":"S25","article-title":"Helicobacter pylori as a promotor of intestinal metaplasia and gastric cancer: an alluring hypothesis in search of evidence","volume":"7","author":"Genta RM","year":"1995","journal-title":"Eur J Gastroenterol Hepatol","ISSN":"http:\/\/id.crossref.org\/issn\/0954-691X","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2036.1998.00003.x","article-title":"Gastric atrophy and atrophic gastritis - nebulous concepts in search of a definition","volume":"12","author":"Genta RM","year":"1998","journal-title":"Aliment Pharmacol Ther","ISSN":"http:\/\/id.crossref.org\/issn\/0269-2813","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0165-4608(00)00306-X","article-title":"Reccurent chromosome changes in 62 primary gastric carcinomas detected by comparative genomic hybridization","volume":"123","author":"Guan XY","year":"2000","journal-title":"Cancer Genetic Cytogenetic"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1056\/NEJM199607253350404","article-title":"The risk of stomach cancer in patients with gastric or duodenal ulcer disease","volume":"335","author":"Hansson L","year":"1996","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02888238","article-title":"Abnormal change of p53 gene in gastric and precancerous lesions and APC gene deletion in gastric carcinoma and near tissues","volume":"17","author":"Hao Y","year":"1997","journal-title":"J Tongji Med Univ","ISSN":"http:\/\/id.crossref.org\/issn\/0257-716X","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ajcp\/108.1.26","article-title":"Enhanced cellular proliferation and p53 accumulation in gastric mucosa chronically infected with Helicobacter pylori","volume":"108","author":"Hibi K","year":"1997","journal-title":"Am J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9173","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1136\/gut.33.4.429","article-title":"Helicobacter pylori: the African enigma","volume":"33","author":"Holcombe C","year":"1992","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref26","first-page":"3421","article-title":"Mutation frequency of the p16\/CDKN2 gene in primary cancers in the upper digestive tract","volume":"55","author":"Igaki H","year":"1995","journal-title":"Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref27","series-title":"Estimativa da incid\u00eancia e mortalidade por c\u00e2ncer no Brasil","year":"2002"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1128\/JCM.38.2.483-488.2000","article-title":"Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in Japan","volume":"38","author":"Ito Y","year":"2000","journal-title":"J Clin Microbiol","ISSN":"http:\/\/id.crossref.org\/issn\/0095-1137","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s005350050344","article-title":"Proliferation and apoptosis in gastric antral epithelial cells of patients infected with Helicobacter pylori","volume":"35","author":"Jang TJ","year":"2000","journal-title":"J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0944-1174","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2559.1979.tb02996.x","article-title":"A histochemical study","volume":"3","author":"Jass JR","year":"1997","journal-title":"Histopathology","ISSN":"http:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0002-9440(10)64007-2","article-title":"Chromosomal alterations in paired gastric adenomas and carcinomas","volume":"158","author":"Kim YH","year":"2001","journal-title":"Am J Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref32","first-page":"3139","article-title":"Different vulnerability among chromosomes to numerical instability in gastric carcinogenesis: stage-dependent analysis by FISH with the use of microwave irradiation","volume":"6","author":"Kitayama Y","year":"2000","journal-title":"Clin Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/1078-0432","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0959-8049(00)00066-6","article-title":"Genetic instability in intestinal metaplasia is a frequent event leading to well-differentiated early adenocarcinoma of the stomach","volume":"36","author":"Kobayashi K","year":"2000","journal-title":"Eur J Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0014-2964","issn-type":"print"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/jcp.49.12.979","article-title":"Risk of gastric carcinoma in patients with mucosal dysplasia associated with atrophic gastritis: a follow-up study","volume":"49","author":"Kokkola A","year":"1996","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF00115637","article-title":"Nutrition and stomach cancer","volume":"7","author":"Kono S","year":"1996","journal-title":"Cancer Causes Control","ISSN":"http:\/\/id.crossref.org\/issn\/0957-5243","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-4608(99)00152-1","article-title":"Genetic alterations of gastric cancer: comparative genomic hybridization and fluorescence in situ hybridization studies","volume":"117","author":"Koo SH","year":"2000","journal-title":"Cancer Genet Cytogenet","ISSN":"http:\/\/id.crossref.org\/issn\/0165-4608","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.1999.00002.x","article-title":"Exploring the link between Helicobacter pylori and gastric cancer","volume":"13","author":"Kuipers EJ","year":"1999","journal-title":"Aliment Pharmacol Ther","ISSN":"http:\/\/id.crossref.org\/issn\/0269-2813","issn-type":"print"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0165-4608(98)00046-6","article-title":"Comparative genomic hybridization reveals differences in DNA copy number changes between sporadic gastric carcinomas and gastric carcinomas from patients with hereditary nonpoluposis colorectal cancer","volume":"106","author":"Larramendy ML","year":"1998","journal-title":"Cancer Genet Cytogenet","ISSN":"http:\/\/id.crossref.org\/issn\/0165-4608","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/jcp.52.5.367","article-title":"Correlation between epithelial cell proliferation and histological grading in gastric mucosa","volume":"52","author":"Lynch DAF","year":"1999","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/ije\/27.4.570","article-title":"Helicobacter pylori infection and mode of transmission in a population at high risk of stomach cancer","volume":"27","author":"Ma JL","year":"1998","journal-title":"Int J Epidemiol","ISSN":"http:\/\/id.crossref.org\/issn\/0300-5771","issn-type":"print"},{"key":"ref41","first-page":"489","article-title":"Mutated p53 in tumors, mutant p53 and p53-specific antibodies in the circulation in patients with gastric cancer","volume":"19","author":"Maeta M","year":"2000","journal-title":"J Exp Clin Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0392-9078","issn-type":"print"},{"key":"ref42","series-title":"Pathology of the gastrointestinal tract","first-page":"607","volume-title":"Malignant epithelial tumors of the stomach","author":"Ming SC","year":"1998","edition":"2"},{"key":"ref43","first-page":"1406","article-title":"Increased gastric epithelial cell apoptosis associated with colonization with cagA+ Helicobacter pylori strains","volume":"61","author":"Moss SF","year":"2001","journal-title":"Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref44","first-page":"1894","article-title":"The prognostic significance of amplification and overexpression of c-met and c-erbB-2 in human gastric carcinomas","volume":"88","author":"Nakajima M","year":"2000","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref45","first-page":"930","article-title":"Carcinoma of the stomach in incipient phase: its histogenesis and histological appearance","volume":"69","author":"Nakamura K","year":"1968","journal-title":"Jpn J Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0910-5050","issn-type":"print"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/gut.44.6.789","article-title":"Effect of Helicobacter pylori infection and its eradication on cell proliferation, DNA status, and oncogene expression in patients with chronic gastritis","volume":"44","author":"Nardone G","year":"1999","journal-title":"Gut","ISSN":"http:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0278-6915(89)90069-0","article-title":"Formation of direct-acting genotoxic substances in nitrosated smoked fish and meat products: identification of simple phenolic precursors and phenyldiazonium ions as reactive products","volume":"27","author":"Oashima H","year":"1989","journal-title":"Food Chem Toxicol","ISSN":"http:\/\/id.crossref.org\/issn\/0278-6915","issn-type":"print"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-4608(99)00182-X","article-title":"Sequential numerical changes of chromosomes 7 and 18 in diffuse-type stomach cancer cell lines: combined comparative genomica hybridization, fluorescence in situ hybridization and ploidy analyses","volume":"118","author":"Okada K","year":"2000","journal-title":"Cancer Genet Cytogenet","ISSN":"http:\/\/id.crossref.org\/issn\/0165-4608","issn-type":"print"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-0463.2000.d01-44.x","article-title":"Absence of mutations in the kinase domain of the Met gene and frequent expression of Met and HGF\/SF protein in primary gastric carcinomas","volume":"108","author":"Park WS","year":"2000","journal-title":"APMIS","ISSN":"http:\/\/id.crossref.org\/issn\/0903-4641","issn-type":"print"},{"key":"ref50","first-page":"531","article-title":"Adherence to gastric epithelial cells induces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome","volume":"110","author":"Peek RM Jr","year":"1998","journal-title":"Proc Assoc Am Physicians","ISSN":"http:\/\/id.crossref.org\/issn\/1081-650X","issn-type":"print"},{"key":"ref51","first-page":"6124","article-title":"Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle","volume":"59","author":"Peek RM","year":"1999","journal-title":"Cancer Res","ISSN":"http:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF00193167","article-title":"Frequency and spectrum of p53 mutations in gastric cancer: a molecular genetic adn immunohistochemical study","volume":"426","author":"Poremba C","year":"1995","journal-title":"Virchows Arch","ISSN":"http:\/\/id.crossref.org\/issn\/0945-6317","issn-type":"print"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1172\/JCI2808","article-title":"Involvement of the CD95 (APO-1\/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis","volume":"102","author":"Rudi J","year":"1998","journal-title":"J Clin Invest","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9738","issn-type":"print"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/1097-0142(20010715)92:2<294::AID-CNCR1322>3.0.CO;2-9","article-title":"DNA aneuploidy and high proliferative activity but not K-ras-2 mutations as independent predictors of clinical in operable gastric carcinoma: results of a 5-year Gruppo Oncologico dell' Italia Meridonale (GDIM) prospective study","volume":"92","author":"Russo A","year":"2001","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000016860","article-title":"Gastric stump cancer: What is the risk","volume":"16","author":"Safatle-Ribeiro A","year":"2001","journal-title":"Dig Dis","ISSN":"http:\/\/id.crossref.org\/issn\/0257-2753","issn-type":"print"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/(SICI)1098-2264(199904)24:4<299::AID-GCC2>3.0.CO;2-U","article-title":"Gains, losses and amplifications of genomic materials in primary gastric cancers analyzed by comparative genomic hybridization","volume":"24","author":"Sakakura C","year":"1999","journal-title":"Genes Chromosomes Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/1045-2257","issn-type":"print"},{"key":"ref57","first-page":"511","article-title":"p53 alteration in gastric precancerous lesions","volume":"144","author":"Shiao YH","year":"1994","journal-title":"Am J Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref58","first-page":"449","article-title":"Antibodies to Helicobacter pylori and pepsinogen levels in children in Costa Rica","volume":"1","author":"Sierra R","year":"1992","journal-title":"Cancer Epidemiol Biomark Prevent"},{"key":"ref59","series-title":"Gastric cancer: Current problems in tumour pathology","first-page":"152","volume-title":"Precancerous conditions","author":"Sipponen P","year":"1985"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/BF01212724","article-title":"Molecular mechanisms of stomach carcinogenesis","volume":"119","author":"Tahara E","year":"1993","journal-title":"J Cancer Res Clin Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0171-5216","issn-type":"print"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0940-2993(98)80019-5","article-title":"Molecular mechanism of human stomach carcinogenesis implicated in Helicobacter pylori infection","volume":"50","author":"Tahara E","year":"1998","journal-title":"Exp Toxicol Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0940-2993","issn-type":"print"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-4608(98)00089-2","article-title":"Analysis of MYC and chromosome 8 copy number changes in gastrointestinal cancers by dual-color fluorescence in situ hybridization","volume":"107","author":"Takahashi Y","year":"1998","journal-title":"Cancer Genet Cytogenet","ISSN":"http:\/\/id.crossref.org\/issn\/0165-4608","issn-type":"print"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0165-4608(00)00231-4","article-title":"Detection of aberrations of 17p and p53 gene in gastrointestinal cancers by dual (two-color) fluorescence in situ hybridization and genechip p53 assay","volume":"121","author":"Takahashi Y","year":"2000","journal-title":"Cancer Genet 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G. 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